IP Library › Granted Patent US 7,696,322
Granted Patent B2
US 7,696,322 · App. 10/900,928 · Granted Apr 13, 2010

Fusion antibodies

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Quick Facts
Patent No.
US 7,696,322
App. No.
10/900,928
Granted
Apr 13, 2010
Kind
B2
Abstract

The present invention provides novel antibodies. In particular, the present invention provides fusion antibodies comprising antibody heavy and light chain fusions. The present invention further provides multivalent antibodies comprising multiple fusion antibody chains. The present invention further provides methods of generating splice resistant antibody genes.

Claims (2)

1. A composition comprising at least two identical polypeptides, each polypeptide comprising an entire antibody heavy chain fused to an entire antibody light chain in a single polypeptide, wherein said light chain is fused at the C-terminus of said heavy chain, wherein said entire antibody heavy chain and said entire antibody light chain are from the same parental immunoglobulin that binds a specific antigen, and wherein said antibody heavy chain is fused to said antibody light chain by the peptide linker of SEQ ID NO:20.

2. A composition comprising a multivalent protein comprising at least five identical polypeptides, wherein each of said polypeptides comprises an entire antibody heavy chain fused to an entire antibody light chain, wherein said light chain is fused at the C-terminus of said heavy chain, and wherein said entire antibody heavy chain and said entire antibody light chain are from the same parental immunoglobulin that binds a specific antigen, and wherein said antibody heavy chain is fused to said antibody light chain by the peptide linker of SEQ ID NO:20.

Assignments (9)
RELEASE OF SECURITY INTEREST IN PATENT COLLATERAL (019323/0302) Recorded Dec 19, 2024
From: JPMORGAN CHASE BANK, N.A.
To: CATALENT PHARMA SOLUTIONS, LLC; R.P. SCHERER TECHNOLOGIES, INC.; R.P. SCHERER TECHNOLOGIES, LLC; R.P. SCHERER CORPORATION
Reel/Frame 069750/0933 →
SECURITY INTEREST Recorded Dec 19, 2024
From: CATALENT CTS (KANSAS CITY), LLC; REDWOOD BIOSCIENCE, INC.; R.P. SCHERER TECHNOLOGIES, LLC; CATALENT WELLNESS, LLC; CATALENT PHARMA SOLUTIONS, INC.; CATALENT WELLNESS NEW JERSEY, LLC; CATALENT MARYLAND, INC.; CATALENT GREENVILLE, INC.; CATALENT MICRON TECHNOLOGIES, INC.; CATALENT SAN DIEGO, INC.; CATALENT WELLNESS VIRGINIA, LLC; CATALENT USA PACKAGING, LLC; CATALENT PHARMA SOLUTIONS, LLC
To: ARES CAPITAL CORPORATION, AS COLLATERAL AGENT
Reel/Frame 069743/0458 →
NOTICE OF SUCCESSION OF AGENCY Recorded May 17, 2019
From: MORGAN STANLEY SENIOR FUNDING, INC.
To: JPMORGAN CHASE BANK, N.A.
Reel/Frame 049217/0981 →
CHANGE OF NAME Recorded Nov 9, 2010
From: CARDINAL HEALTH PTS, LLC
To: CATALENT PHARMA SOLUTIONS, LLC
Reel/Frame 025339/0017 →
CHANGE OF NAME Recorded Apr 30, 2008
From: CARDINAL HEALTH 409, INC. (A DELAWARE CORPORATION)
To: CATALENT PHARMA SOLUTIONS, INC. (A DELAWARE CORPORATION)
Reel/Frame 020878/0192 →
CHANGE OF NAME Recorded Apr 30, 2008
From: R. P. SCHERER CORPORATION (A DELAWARE CORPORATION)
To: CARDINAL HEALTH 409, INC. (A DELAWARE CORPORATION)
Reel/Frame 020878/0188 →
CHANGE OF NAME Recorded Jul 24, 2007
From: CARDINAL HEALTH 400, INC.; CARDINAL HEALTH 406, LLC; CARDINAL HEALTH 409, INC.; CARDINAL HEALTH 421, INC.; CARDINAL HEALTH PTS, LLC
To: CATALENT USA WOODSTOCK, INC.; CATALENT USA PACKAGING, LLC; CATALENT PHARMA SOLUTIONS, INC.; CATALENT USA PAINTBALL, INC.; CATALENT PHARMA SOLUTIONS, LLC
Reel/Frame 019588/0622 →
SECURITY AGREEMENT Recorded May 22, 2007
From: PTS ACQUISITION CORP.; PTS INTERMEDIATE HOLDINGS LLC; CARDINAL HEALTH 400, INC.; CARDINAL HEALTH 406, LLC; CARDINAL HEALTH 421, INC.; CARDINAL HEALTH PTS, LLC; R.P. SCHERER TECHNOLOGIES, INC.; GLACIER CORPORATION; CARDINAL HEALTH 409, INC.
To: MORGAN STANLEY SENIOR FUNDING, INC.
Reel/Frame 019323/0302 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 29, 2004
From: BLECK, GREGORY T.; YORK, DONA; COLLLINS, IAN
To: CARDINAL HEALTH PTS, LLC
Reel/Frame 016033/0425 →