Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
View Patent ↗The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lups erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.
1. N4-(2,2-dimethyl-3-oxo-4H-5-pyrid[1,4]oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine and/or a pharmaceutically acceptable salt, hydrate, solvate and/or N-oxide thereof.
2. A pharmaceutical composition comprising N4-(2,2-dimethyl-3-oxo-4H-5-pyrid[1,4]oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine and/or a pharmaceutically acceptable salt, hydrate, solvate and/or N-oxide thereof.
3. A method of treating rheumatoid arthritis, comprising administering to a subject suffering from rheumatoid arthritis a therapeutically effective amount of N4-(2,2-dimethyl-3-oxo-4H-5-pyrid[1,4]oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine and/or a pharmaceutically acceptable salt, hydrate, solvate and/or N-oxide thereof.
4. The method of claim 3 in which the subject is a human.
5. A method of treating rheumatoid arthritis, comprising administering to a subject suffering from rheumatoid arthritis a therapeutically effective amount of a pharmaceutical composition according to claim 2 .
6. The method of claim 5 in which the subject is a human.