IP Library › Granted Patent US 7,550,431
Granted Patent B2
US 7,550,431 · App. 10/911,219 · Granted Jun 23, 2009

Spatially-defined macrocycles incorporating peptide bond surrogates

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Quick Facts
Patent No.
US 7,550,431
App. No.
10/911,219
Granted
Jun 23, 2009
Kind
B2
Abstract

Novel spatially-defined macrocyclic compounds incorporating peptide bond surrogates are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.

Claims (183)

1. A compound of formula (I):

wherein A 4 is not present, A 3 is covalently bonded to T, and X, A 1 , A 2 , A 3 and T are selected from the group consisting of

X

A 1

NH

NH

NH

NH

NH

NH

NH

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NH

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X

A 2

A 3

NH

NH

NH

NH

NH

NH

NH

NH

NH

NH

NH

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T

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wherein (X) indicates the point of attachment of T to X and (A 3 ) indicates the point of attachment of T to A 3 .

2. An antagonist of a mammalian motilin receptor having the following structure:

3. An agonist of a mammalian ghrelin receptor having the following structure:

Assignments (5)
RELEASE OF PATENT SECURITY INTERESTS RECORDED AT REEL 044949, FRAME 0634 Recorded Nov 16, 2023
From: DEUTSCHE BANK AG NEW YORK BRANCH, AS COLLATERAL AGENT
To: MALLINCKRODT INTERNATIONAL FINANCE S.A.; MALLINCKRODT CB LLC; MALLINCKRODT FINANCE GMBH; MALLINCKRODT US HOLDINGS LLC (F/K/A MALLINCKRODT US HOLDINGS INC.); MALLINCKRODT CARRIBEAN, INC.; MALLINCKRODT US POOL LLC; MNK 2011 LLC (F/K/A MALLINCKRODT INC.); LUDLOW LLC (F/K/A LUDLOW CORPORATION); CNS THERAPEUTICS, INC.; MALLINCKRODT ENTERPRISES HOLDINGS LLC (F/K/A MALLINCKRODT ENTERPRISES HOLDINGS, INC.); MALLINCKRODT ENTERPRISES LLC; MALLINCKRODT LLC; LAFAYETTE PHARMACEUTICALS LLC; LIEBEL-FLARSHEIM COMPANY LLC; MALLINCKRODT BRAND PHARMACEUTICALS LLC (F/K/A MALLINCKRODT BRAND PHARMACEUTICALS, INC.); MALLINCKRODT VETERINARY, INC.; MALLINCKRODT US HOLDINGS LLC; IMC EXPLORATION COMPANY; MEH, INC.; MALLINCKRODT HOSPITAL PRODUCTS IP UNLIMITED COMPANY (F/K/A MALLINCKRODT HOSPITAL PRODUCTS IP LIMITED); MALLINCKRODT ARD IP UNLIMITED COMPANY (F/K/A MALLINCKRODT ARD IP LIMITED); OCERA THERAPEUTICS LLC (F/K/A OCERA THERAPEUTICS, INC.); SPECGX LLC; STRATATECH CORPORATION; SUCAMPO PHARMA AMERICAS LLC; VTESSE LLC (F/K/A VTESSE INC.); MALLINCKRODT PHARMACEUTICALS IRELAND LIMITED; MALLINCKRODT PHARMA IP TRADING UNLIMITED COMPANY (F/K/A MALLINCKRODT PHARMA IP TRADING D.A.C.); INFACARE PHARMACEUTICAL CORPORATION; ST SHARED SERVICES LLC; THERAKOS, INC.; IKARIA THERAPEUTICS LLC; INO THERAPEUTICS LLC
Reel/Frame 065610/0460 →
NOTICE OF GRANT OF SECURITY INTEREST IN INTELLECTUAL PROPERTY Recorded Dec 22, 2017
From: OCERA THERAPEUTICS, INC.
To: DEUTSCHE BANK AG NEW YORK BRANCH, AS COLLATERAL AGENT
Reel/Frame 044949/0634 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 17, 2014
From: TRANZYME PHARMA INC.
To: OCERA THERAPEUTICS, INC.
Reel/Frame 031994/0084 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 28, 2009
From: FRASER, GRAEME L.
To: TRANZYME PHARMA INC.
Reel/Frame 023292/0464 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 3, 2005
From: DESLONGCHAMPS, PIERRE; DORY, YVES; OUELLET, LUC; VILLENEUVE, GERALD; RAMASESHAN, MAHESH; FORTIN, DANIEL; PETERSON, MARK; HOVEYDA, HAMID; BEAUBIEN, SYLVLE; MARSAULT, ERIC
To: TRANZYME PHARMA INC.
Reel/Frame 015655/0375 →