Hyaluronic acid-associated superoxide dismutase mimics and their use in the treatment of joint pain
Herein is disclosed a composition, comprising a superoxide dismutase mimic (SODm) associated with hyaluronic acid (HA), wherein the composition is a liquid at about 37° C. The composition is useful in a method of treating pain or inflammation in a joint of a mammal, comprising (i) providing the composition and (ii) injecting the composition into or close to the joint.
1 - 6 . (Canceled)
7 . A method of reducing the mean size of osteophytes in a joint of a mammal, comprising:
(i) providing a composition, comprising a superoxide dismutase mimic (SODm) associated with hyaluronic acid (HA), wherein the composition is a liquid at about 37° C.; and,
(ii) injecting the composition into or close to the joint.
8 . The method of claim 7 , wherein the mammal is a human.
9 . The method of claim 7 , wherein the joint is a knee.
10 . The method of claim 9 , wherein the composition is injected into the knee.
11 . The method of claim 7 , wherein the SODm is associated with the HA by a chemical bond.
12 . The method of claim 11 , wherein the chemical bond is selected from the group consisting of a covalent bond and an ionic bond.
13 . The method of claim 12 , wherein the chemical bond is a covalent bond and the covalent bond is selected from the group consisting of an amide bond, an ester bond, and an ether bond.
14 . The method of claim 7 , wherein the SODm has structure I:
wherein X is selected from the group consisting moieties comprising —H, moieties comprising —NH 2 , moieties comprising —COOH, and moieties comprising —CHOH; and Z 1 and Z 2 are independently -halide.
15 . The method of claim 14 , wherein X is —S—(CH 2 ) 2 —NH 2 , and Z 1 and Z 2 are each —Cl.
16 . The method of claim 7 , wherein the dose of SODm is from about 0.01 mg SODm/kg body weight to about 10 mg SODm/kg body weight.