Granted Patent
B2
US 7,576,206 · App. 10/918,664 · Granted Aug 18, 2009
Proteasome inhibitors and methods of using the same
Assignee:
Cephalon, Inc.
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Abstract
The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.
Claims (1)
1. Boronic acid, [(1R)-1-[[(2S,3R)-3-hydroxy-2-[(6-phenyl-pyridine-2-carbonyl)amino]-1-oxobutyl]amino]-3-methylbutyl], or a pharmaceutically acceptable salt thereof.
Assignments (6)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Nov 10, 2022
From: MILLENNIUM PHARMACEUTICALS, INC.
To: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Reel/Frame 061725/0893 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Dec 11, 2015
From: TEVA PHARMACEUTICALS
To: MILLENNIUM PHARMACEUTICALS, INC.
Reel/Frame 037267/0401 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Feb 6, 2006
From: CELL THERAPEUTICS EUROPE S.R.L.
To: CEPHALON, INC.
Reel/Frame 017126/0468 →
CORRECTIVE ASSIGNMENT
Recorded Jan 18, 2005
From: BERNARDINI, RAFFAELLA; BERNAREGGI, ALBERTO; CASSARA, PAOLO G.; D'ARASMO, GERMANO; DE MUNARI, SERGIO; FERRETTI, EDMONDO; MENTA, ERNESTO; OLIVA, AMBROGIO
To: CELL THERAPEUTICS EUROPE S.R.L.
Reel/Frame 015604/0647 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Dec 22, 2004
From: BERNARDINI, RAFFAELLA; BERNAREGGI, ALBERTO; CASSARA, PAOLO G.; D'ARASMO, GERMANO; DE MUNARI, SERGIO; FERRETTI, EDMONDO
To: CELL THERAPEUTICS EUROPE S.R.L.
Reel/Frame 015484/0553 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Dec 22, 2004
From: CHATTERJEE, SANKAR; IQBAL, MOHAMED; MESSINA MCLAUGHLIN, PATRICIA A.
To: CEPHALON, INC.
Reel/Frame 015484/0560 →
Continuity (2)
Provisional Application
6049576400
· Aug 14, 2003