Thermally modified microbial-derived cellulose for in vivo implantation
View Patent ↗A thermally modified microbial-derived cellulose material is described for use as an implantable material in general surgery, plastic surgery and neurosurgery.
1. A method for preparing an implantable or topical material for general surgery or plastic surgery comprising:
providing a microbial cellulose;
treating said microbial cellulose to render said cellulose non-pyrogenic;
partially dehydrating said microbial cellulose by exposing it to temperatures below 0° C., then exposing said microbial cellulose to temperatures above 0° C.; and
subsequently discarding liquid that was removed,
wherein the general surgery comprises general soft tissue augmentation, pelvic floor reconstruction, bladder neck suspension, hernia repair, or inguinal hernia patch.
2. A method for preparing an implantable or topical material for general surgery or plastic surgery comprising:
providing a microbial cellulose;
treating said microbial cellulose to render said cellulose non-pyrogenic;
partially dehydrating said microbial cellulose by exposing it to temperatures below 0° C., then exposing said microbial cellulose to temperatures above 0° C.; and
subsequently discarding liquid that was removed,
wherein a percentage elongation of the material ranges between 9.3% and 13.3%.
3. A method for implanting an implantable material during a general surgery or a plastic surgery into a subject in need thereof, comprising implanting the material into the subject, wherein the material is prepared by a method comprising:
providing a microbial cellulose;
treating said microbial cellulose to render said cellulose non-pyrogenic;
partially dehydrating said microbial cellulose by exposing it to temperatures below 0° C., then exposing said microbial cellulose to temperatures above 0° C.; and
subsequently discarding liquid that was removed.
4. The method of claim 3 , wherein the general surgery comprises general soft tissue augmentation, pelvic floor reconstruction, bladder neck suspension, hernia repair, or inguinal hernia patch.
5. The method of claim 3 , wherein a percentage elongation of the material ranges between 9.3% and 13.3%.
6. The method of claim 3 , wherein the material is conformable.