Devices and methods for delivering agents to tissue region while preventing leakage
An apparatus for delivering a therapeutic or diagnostic agent to a target site within a body includes an outer tubular body, an inner tubular body slidably disposed within the outer tubular body, a substance delivery port located on the inner tubular body, and an electrode secured to the outer tubular body. The delivery port can be used to deliver a medical substance to the target site, and the electrode can be used to seal an access channel leading to the treatment site, thereby substantially preventing migration of material from the delivery site. In order to minimize the profile of the apparatus, a braided conductor can extend through the wall of the outer tubular body, thereby providing a means for delivering electrical energy to the electrode, while strengthening the wall of the outer tubular body to minimize the risk of rupture during delivery of the substance.
1 . An apparatus for delivering a medical substance to a target site within a body, comprising:
an outer tubular body having a distal end and a first lumen;
an inner tubular body having a distal end and a second lumen, wherein the inner tubular body is slidably disposed within the first lumen, such that the distal end of the inner tubular body can extend beyond the distal end of the outer tubular body;
a substance delivery port located on the distal end of the inner tubular body in fluid communication with the second lumen; and
a first electrode secured to the distal end of the outer tubular body.
2 . The apparatus of claim 1 , further comprising a second electrode secured to the distal end of the inner tubular body.
3 . The apparatus of claim 1 , further comprising a source of medical substance coupled to the second lumen.
4 . The apparatus of claim 3 , wherein the substance is a therapeutic agent.
5 . The apparatus of claim 1 , further comprising an aspiration port located on the outer tubular body.
6 . The apparatus of claim 1 , wherein the outer tubular body is a rigid shaft.
7 . The apparatus of claim 1 , wherein the outer tubular body is a flexible catheter body.
8 . The apparatus of claim 1 , wherein the inner tubular body is a needle.
9 . A method for delivering a medical substance to a target site within a body, comprising:
advancing a tubular body through a channel to the target site;
delivering the substance via the tubular body to the target site; and
delivering ablation energy to seal the channel adjacent to the target site, whereby material is prevented from substantially migrating from the target site.
10 . The method of claim 9 , wherein the target site is a tumor.
11 . The method of claim 9 , further comprising aspirating at least some of the delivered substance from the channel or target site.
12 . The method of claim 9 , wherein the tubular body is a needle.
13 . The method of claim 9 , wherein the channel is a needle tract.
14 . The method of claim 9 , wherein the channel is a lumen of a blood vessel.
15 . The method of claim 9 , wherein the channel is a medullary canal of a bone.
16 . The method of claim 9 , wherein the material that is prevented from migrating from the target site is toxic.
17 . The method of claim 9 , wherein the material that is prevented from migrating from the target site is the medical substance.
18 . The method of claim 9 , wherein the ablation energy is electrical energy.
19 . The method of claim 9 , wherein the ablation energy is delivered from the tubular body.
20 . A medical probe, comprising:
a probe shaft having a distal end, a tubular wall, and a lumen;
a first electrode secured to the distal end of the probe shaft;
a braided conductor extending through the wall of the probe shaft in electrical communication with the first electrode; and
a substance delivery port at the distal end of the probe shaft in fluid communication with the lumen.
21 . The probe of claim 20 , wherein the probe shaft comprises:
an outer tubular body formed by the tubular wall; and
an inner tubular body defining the lumen.
22 . The probe of claim 21 , wherein the electrode is secured to the outer tubular body, and the delivery port is located on the inner tubular body.
23 . The probe of claim 22 , further comprising a second electrode secured to the inner tubular body.
24 . The probe of claim 20 , wherein the probe shaft is flexible.