Sulpiride pharmaceutical compositions
The present invention relates to pharmaceutical compositions containing sulpiride compounds having the general formula: where R 1 is branched or straight chain alkyl having from 1 to about 7 carbon atoms, a substituted or unsubstituted aryl, a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted aralkyl, a substituted or unsubstituted alkylcycloalkyl, or a group having the formula (CH 2 ) n R 2 where R 2 is a substituted or unsubstituted aryl or a substituted or unsubstituted cycloalkyl, and n is an alkyl group having from 0 to about 6 carbon atoms and pharmaceutically acceptable salts or diluents.
1. A compound having the formula:
where R 1 is branched or strain chain alkyl having from 1 to about 7 carbon atoms, an unsubstituted aryl, a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted aralkyl, a substituted or unsubstituted alkylcycloalkyl, or a group having the formula (CH 2 ) n R 2 where R 2 is a substituted or unsubstituted aryl or a substituted or unsubstituted cycloalkyl, and n is an alkyl group having from 0 to about 6 carbon atoms,
or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1 , wherein R 1 is methyl, ethyl, propyl, isopropyl, butyl, isobutyl, pentyl, isopentyl or hexyl.
3. The compound of claim 1 , wherein R 1 is a straight chain lower alkyl having from 1 to about 6 carbon atoms.
4. The compound of claim 3 , wherein R 1 is methyl, ethyl, or propyl.
5. The compound of claim 1 , 2 or 3 , wherein the compound is the levorotary isomer.
6. A pharmaceutical composition comprising a compound having the formula:
where R 1 is branched or strain chain alkyl having from 1 to about 7 carbon atoms, an unsubstituted aryl, a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted aralkyl, a substituted or unsubstituted alkylcycloalkyl, or a group having the formula (CH 2 ) n R 2 where R 2 is a substituted or unsubstituted aryl or a substituted or unsubstituted cycloalkyl, and n is an alkyl group having from 0 to about 6 carbon atoms and
a pharmaceutically acceptable salt or diluent.
7. The pharmaceutical composition of claim 6 , wherein R 1 is methyl, ethyl, propyl, isopropyl, butyl, isobutyl, pentyl, isopentyl or hexyl.
8. The compound of claim 7 , wherein R 1 is a straight chain lower alkyl having from 1 to about 6 carbon atoms.
9. The compound of claim 8 , wherein R 1 is methyl, ethyl, or propyl.
10. The compound of claim 6 , 7 or 8 , wherein the compound is the levorotary isomer.
11. The composition of claim 6 wherein said compound has the formula
12. The composition of claim 10 wherein said compound has the formula
13. The composition of claim 11 wherein said composition is a parenteral formulation.
14. The composition of claim 11 wherein said composition is an oral formulation.
15. The composition of claim 12 wherein said composition is a parenteral formulation.
16. The composition of claim 12 wherein said composition is an oral formulation.