Antimicrobial compositions and methods
View Patent ↗Antimicrobial compositions, especially those useful when applied topically, particularly to mucosal tissues (i.e., mucous membranes), including, in particular, an antimicrobial lipid component, such as a fatty acid ester, fatty ether, or alkoxide derivative thereof. The compositions can also include an enhancer component, a surfactant, a hydrophobic component, and/or a hydrophilic component. Such compositions provide effective topical antimicrobial activity and are accordingly useful in the treatment and/or prevention of conditions that are caused, or aggravated by, microorganisms (including viruses).
1. An antimicrobial composition comprising:
0.1 wt-% to 20 wt-% of an antimicrobial lipid component comprising a (C7-C12)saturated fatty acid monoester of a polyhydric alcohol or an alkoxylated derivative thereof, a (C8-C22)unsaturated fatty acid monoester of a polyhydric alcohol or an alkoxylated derivative thereof, or combinations thereof, and the antimicrobial lipid component further includes no greater than 15 wt-%, based on the total weight of the antimicrobial lipid component, of a di- or tri-ester or an alkoxylated derivative thereof, a di- or tri-ether or an alkoxylated derivative thereof, or combinations thereof;
0.01 wt-% to 20 wt-% of an enhancer component comprising an alpha-hydroxy acid, a beta-hydroxy acid, a chelating agent, a (C1-C4)alkyl carboxylic acid, a (C6-C12)aryl carboxylic acid, a (C6-C12)aralkyl carboxylic acid, a (C6-C12)alkaryl carboxylic acid, a phenolic compound, a (C1-C10)alkyl alcohol, an ether glycol, or combinations thereof, wherein the total concentration of the enhancer component relative to the total concentration of lipid component is within a range of 10:1 to 1:300, on a weight basis;
0.1 wt-% to 10 wt-% of a surfactant distinct from the antimicrobial lipid component, wherein the total concentration of the surfactant to the total concentration of antimicrobial lipid component is within a range of 5:1 to 1:100, on a weight basis;
1 wt-% to 40 wt-% of a hydrophilic component that will dissolve or disperse in water at a temperature of 23° C. in an amount of at least 7% by weight, based on the total weight of the hydrophilic component and the water;
50 wt-% to 95 wt-% of a hydrophobic component that will dissolve or disperse in water at a temperature of 23° C. in an amount of less than 5% by weight, based on the total weight of the hydrophobic component and the water; and
less than 10 wt-% water;
wherein the composition has at least 4 log reduction in test bacteria in 10 minutes when evaluated by the Antimicrobial Efficacy Test; and wherein the antimicrobial lipid component is different from the hydrophobic component.
2. The antimicrobial composition of claim 1 , wherein the composition comprises:
1 wt-% to 10 wt-% of the antimicrobial lipid component;
0.4 wt-% to 20 wt-% of the enhancer component, wherein the total concentration of the enhancer component relative to the total concentration of the antimicrobial lipid component is within a range of 5:1 and 1:10, on a weight basis;
0.1 wt-% to 2 wt-% of the surfactant, wherein the total concentration of the surfactant to the total concentration of antimicrobial lipid component is within a range of 2:1 to 1:3, on a weight basis;
10 wt-% to 40 wt-% of the hydrophilic component; and
less than 2 wt-% water.
3. The antimicrobial composition of claim 2 , wherein:
the enhancer component comprises a carboxylic acid or an alpha-hydroxy acid;
the surfactant comprises a sulfonate, a sulfate, a phosphonate, a phosphate, a poloxamer, a cationic surfactant, or mixtures thereof;
the hydrophilic component comprises a glycol, a C1-C4 alcohol ether, a short chain alkyl ester, or combinations thereof, wherein the hydrophilic component is soluble in water in an amount of at least 20 wt-% at 23° C.; and
the hydrophobic component is an organic compound that is liquid, gelatinous, semisolid, or solid at 23° C. and has a solubility in water of less than 5 wt-% at 23° C.