Process for preparation of benzylpiperidine compounds
View Patent ↗According to the process as shown in the following scheme having a step for reacting Compound (I) with Compound (II) to produce Compound (III), benzylpiperidine compounds useful as synthesis starting materials of pharmaceutical agents, agricultural chemicals and the like can be produced conveniently by a short step: wherein R 1 is a hydrogen atom or an amino-protecting group, R 2 is a hydrogen atom, a hydrocarbon group optionally having substituents, an alkoxy group optionally having substituents or a heterocyclic group optionally having substituents, and R 3 is a lower alkyl group.
1. A process for the preparation of a compound represented by the formula:
wherein
R 1 is a hydrogen atom or an amino-protecting group and
R 2 is a hydrogen atom, a hydrocarbon group optionally having substituents, an alkoxy group optionally having substituents or a heterocyclic group optionally having substituents,
or a salt thereof, which comprises reacting a compound represented by the formula:
wherein R 3 is a lower alkyl group and R 2 is as defined above, or a salt thereof, with a compound represented by the formula:
wherein R 1 is as defined above, or a salt thereof.
2. A process for the preparation of a compound represented by the formula:
wherein
R 1 is a hydrogen atom or an amino-protecting group and
R 2 is a hydrogen atom, a hydrocarbon group optionally having substituents, an alkoxy group optionally having substituents or a heterocyclic group optionally having substituents,
or a salt thereof, which comprises reacting a compound represented by the formula:
wherein X 1 is a halogen atom and R 2 is as defined above, or a salt thereof, with a trialkyl phosphite represented by the formula:
(R 3 O) 3 P (V)
wherein R 3 is a lower alkyl group, and thereafter reacting with a compound represented by the formula:
wherein R 1 is as defined above, or a salt thereof.
3. The process of claim 2 , wherein the compound represented by the formula (IV) or a salt thereof is reacted with the trialkyl phosphite represented by the formula (V) to give a compound represented by the formula:
wherein
R 2 is a hydrogen atom, a hydrocarbon group optionally having substituents, an alkoxy group optionally having substituents or a heterocyclic group optionally having substituents, and
R 3 is a lower alkyl group,
or a salt thereof.
4. A process for the preparation of a compound represented by the formula:
wherein
R 2 is a hydrogen atom, a hydrocarbon group optionally having substituents, an alkoxy group optionally having substituents or a heterocyclic group optionally having substituents,
or a salt thereof, which comprises:
reacting a compound represented by the formula:
wherein X 1 is a halogen atom and X 2 is a leaving group, with a compound represented by the formula:
R 2 NH 2 (VII)
wherein R 2 is as defined above, or a salt thereof, to give a compound represented by the formula:
wherein R 2 and X 1 are as defined above, or a salt thereof;
reacting the compound represented by the formula (IV) or a salt thereof with a trialkyl phosphite represented by the formula:
(R 3 O) 3 P (V)
wherein R 3 is a lower alkyl group;
thereafter reacting with a compound represented by the formula:
wherein R 1 is a hydrogen atom or an amino-protecting group, or a salt thereof, to give a compound represented by the formula:
wherein R 1 and R 2 are as defined above, or a salt thereof; and
reducing and thereafter where necessary deprotecting the compound represented by the formula(III) or a salt thereof.
5. The process of claim 4 which comprises:
reacting a compound represented by the formula:
wherein X 1 and X 2′ are each a halogen atom, with a compound represented by the formula:
R 2 NH 2 (VII)
wherein R 2 is a hydrogen atom, a hydrocarbon group optionally having substituents, an alkoxy group optionally having substituents or a heterocyclic group optionally having substituents, or a salt thereof, to give a compound represented by the formula:
wherein R 2 and X 1 are as defined above, or a salt thereof;
reacting the compound represented by the formula (IV) or a salt thereof with a trialkyl phosphite represented by the formula:
(R 3 O) 3 P (V)
wherein R 3 is a lower alkyl group, to give a compound represented by the formula:
wherein R 2 and R 3 are as defined above, or a salt thereof;
reacting the compound represented by the formula (I) or a salt thereof with a compound represented by the formula:
wherein R 1 is a hydrogen atom or an amino-protecting group, or a salt thereof, to give a compound represented by the formula:
wherein R 1 and R 2 are as defined above, or a salt thereof; and
reducing and thereafter where necessary deprotecting the compound represented by formula (III) or a salt thereof.
6. The process of claim 1 wherein the compound represented by the formula (II) or a salt thereof is reacted in the presence of a base.
7. The process of claim 6 , wherein the base is t-butoxide of an alkali metal.
8. The process of claim 7 , wherein the base is potassium t-butoxide.
9. A compound represented by the formula:
10. The process of claim 2 , wherein the compound represented by the formula (IV) or a salt thereof is reacted with the compound represented by the formula (V) in the presence of alkali metal iodide.
11. The process of claim 2 , wherein the compound represented by the formula (II) or a salt thereof is reacted in the presence of a base.
12. The process of claim 4 , wherein the compound represented by the formula (IV) or a salt thereof is reacted with the compound represented by the formula (V) in the presence of alkali metal iodide.
13. The process of claim 4 , wherein the compound represented by the formula (II) or a salt thereof is reacted in the presence of a base.