IP Library Granted Patent US 7,595,429
Granted Patent B2
US 7,595,429 · App. 10/939,687 · Granted Sep 29, 2009

Calcium zeolite hemostatic agent

Assignee: Z-Medica Corporation
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 7,595,429
App. No.
10/939,687
Granted
Sep 29, 2009
Kind
B2
Abstract

A composition for promoting the formation of clots in blood comprises a binder and a zeolite disposed in the binder, the zeolite having an adjusted calcium content. A method of forming a blood-clotting composition comprises the steps of providing a zeolite, combining the zeolite with a binder, and adjusting a calcium content of the zeolite to have an amount of calcium such that upon application of the composition to a wound, a heat of hydration is reduced and thereby heat transferred to the wound is reduced. A method of clotting blood flowing from a wound comprises the steps of applying a zeolite to the wound and maintaining the zeolite in contact with the wound for a predetermined amount of time. The zeolite preferably has an adjusted calcium content and is capable of producing a controllable blood clotting effect on the wound.

Claims (12)

1. A composition for promoting the formation of clots in blood, said composition comprising: a binder; a zeolite disposed in said binder, said zeolite having an adjusted calcium content via the addition of a calcium-containing compound to said zeolite, said calcium content being between about 75 wt. % to about 83 wt. %, said composition being operable to reduce a heat of hydration when exposed to blood.

2. The composition of claim 1 , wherein said zeolite comprises aluminosilicate.

3. The composition of claim 1 , wherein said adjusted calcium content is obtained via the addition of a calcium-containing compound to a starting zeolite, said calcium-containing compound being selected from the group consisting of calcium oxides, calcium sulfates, and calcium chlorides.

4. The composition of claim 1 , wherein said zeolite is nanoporous.

5. The composition of claim 1 , wherein said binder is clay-based.

6. The composition of claim 1 , wherein said composition is of an irregularly-shaped granular form having a size distribution determined by sieving ground material with 40 mesh and 16 mesh cut-off screens.

7. A method of forming a blood-cloning composition, said method comprising the steps of: providing a zeolite; combining said zeolite with a binder; and adjusting a calcium content of said zeolite via the addition of a calcium-containing compound to said zeolite, said calcium content being about 75 wt. % to about 83 wt. % and such that upon application of said composition to a wound, a heat of hydration is reduced and thereby heat transferred to said wound is reduced.

8. The method of claim 7 , wherein said adjusting said calcium content of said zeolite comprises supplementing said zeolite with a calcium-containing compound such that said calcium content is about 83 wt. %.

9. A method of clotting blood flowing from a wound, said method comprising the steps of:

providing a zeolite having a calcium content adjusted via the addition of a calcium-containing compound to said zeolite, said calcium content being about 75 wt. % to about 83 wt. %, and said zeolite being disposed in a clay binder;

applying said zeolite to said wound, said zeolite being capable of producing a controllable blood clotting effect on said wound such that a heat of hydration is reduced; and

maintaining said zeolite in contact with said wound for an amount of time sufficient to cause blood flowing from said wound to clot.

Assignments (20)
SECURITY INTEREST Recorded Mar 1, 2024
From: TELEFLEX LIFE SCIENCES II LLC
To: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 066723/0376 →
MERGER Recorded Feb 29, 2024
From: TELEFLEX LIFE SCIENCES II LLC
To: TELEFLEX TECHNOLOGIES LLC
Reel/Frame 066707/0695 →
CHANGE OF NAME Recorded Feb 29, 2024
From: TELEFLEX TECHNOLOGIES LLC
To: TELEFLEX LIFE SCIENCES II LLC
Reel/Frame 066836/0737 →
MERGER Recorded Feb 16, 2024
From: TELEFLEX LIFE SCIENCES II LLC
To: TELEFLEX TECHNOLOGIES LLC
Reel/Frame 066621/0946 →
CHANGE OF NAME Recorded Feb 16, 2024
From: TELEFLEX TECHNOLOGIES LLC
To: TELEFLEX LIFE SCIENCES II LLC
Reel/Frame 066621/0882 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 16, 2024
From: TELEFLEX LIFE SCIENCES LIMITED
To: TELEFLEX LIFE SCIENCES II LLC
Reel/Frame 066616/0701 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 1, 2024
From: TELEFLEX LIFE SCIENCES LIMITED
To: TELEFLEX LIFE SCIENCES II LLC
Reel/Frame 066434/0248 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 14, 2022
From: Z-MEDICA, LLC
To: TELEFLEX LIFE SCIENCES LIMITED
Reel/Frame 058740/0387 →
SECURITY INTEREST Recorded Mar 2, 2021
From: Z-MEDICA, LLC
To: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 055455/0099 →
RELEASE OF SECURITY INTEREST Recorded Jan 6, 2021
From: TWIN BROOK CAPITAL PARTNERS, LLC
To: Z-MEDICA, LLC
Reel/Frame 054832/0770 →
CORRECTIVE ASSIGNMENT TO CORRECT THE INADVERTENT OMISSION OF APPLICATION NO. 14/185873 FROM THE COVER SHEET PREVIOUSLY RECORDED AT REEL: 044151 FRAME: 0282. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Sep 22, 2020
From: MADISON CAPITAL FUNDING LLC
To: Z-MEDICA, LLC
Reel/Frame 054882/0904 →
RELEASE OF SECURITY INTEREST RECORDED AT REEL/FRAME 035308/0704 Recorded Oct 9, 2017
From: MADISON CAPITAL FUNDING LLC
To: Z-MEDICA, LLC
Reel/Frame 044151/0282 →
SECURITY INTEREST Recorded Sep 29, 2017
From: Z-MEDICA, LLC
To: TWIN BROOK CAPITAL PARTNERS, LLC, AS AGENT
Reel/Frame 043738/0690 →
RELEASE AND REASSIGNMENT Recorded Apr 9, 2015
From: ABACUS FINANCE GROUP, LLC
To: Z-MEDICA, LLC
Reel/Frame 035389/0800 →
MERGER Recorded Apr 1, 2015
From: Z-MEDICA CORPORATION
To: Z-MEDICA, LLC
Reel/Frame 035353/0423 →
SECURITY INTEREST Recorded Apr 1, 2015
From: Z-MEDICA, LLC
To: MADISON CAPITAL FUNDING LLC, AS AGENT
Reel/Frame 035308/0704 →
SECURITY AGREEMENT Recorded Sep 6, 2012
From: Z-MEDICA, LLC
To: ABACUS FINANCE GROUP, LLC
Reel/Frame 028917/0898 →
MERGER Recorded Sep 4, 2012
From: Z-MEDICA CORPORATION
To: Z-MEDICA, LLC
Reel/Frame 028896/0108 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 26, 2005
From: Z-MEDICA, LLC
To: Z-MEDICA CORPORATION
Reel/Frame 016585/0177 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 15, 2004
From: HURSEY, FRANCIS X.
To: Z-MEDICA
Reel/Frame 015357/0527 →
Continuity (2)
Provisional Application 6050259800 · Sep 12, 2003
Related Publication 20050074505A1 · Apr 7, 2005