IP Library › Granted Patent US 7,045,126
Granted Patent B2
US 7,045,126 · App. 10/941,947 · Granted May 16, 2006

Histone deacetylase-8 proteins, nucleic acids, and methods for use

View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 7,045,126
App. No.
10/941,947
Granted
May 16, 2006
Kind
B2
Abstract

The present invention is directed to novel nucleic acids that encode novel HDAC proteins, which have an affect on chromatin structure and transcription. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods of producing the polypeptides of the present invention. Further provided by the present invention are methods of identifying novel compositions which mediate HDAC8 and the use of such compositions in diagnosis and treatment of disease.

Claims (6)

1. An isolated polypeptide, wherein the amino acid sequence of said polypeptide consists of SEQ ID NO:2.

2. An isolated polypeptide, wherein the amino acid sequence of said polypeptide comprises SEQ ID NO:2.

3. A fusion polypeptide, wherein the fusion polypeptide comprises the polypeptide of claim 2 fused to a heterologous amino acid sequence.

4. A composition comprising the polypeptide of claim 1 and a carrier.

5. A composition comprising the polypeptide of claim 2 and a carrier.

6. A composition comprising the polypeptide of claim 3 and a carrier.

Assignments (8)
CORRECTIVE ASSIGNMENT TO CORRECT THE CONVEYING PARTY DATA PREVIOUSLY RECORDED ON REEL 036126 FRAME 0377. ASSIGNOR(S) HEREBY CONFIRMS THE MERGER. Recorded May 17, 2016
From: OXFORD AMHERST CORPORATION; PHARMACYCLICS, INC.
To: PHARMACYCLICS, INC.
Reel/Frame 038722/0776 →
CORRECTIVE ASSIGNMENT TO CORRECT THE CONVEYING PARTY DATA PREVIOUSLY RECORDED ON REEL 036126 FRAME 0398. ASSIGNOR(S) HEREBY CONFIRMS THE MERGER AND CHANGE OF NAME. Recorded May 17, 2016
From: PHARMACYCLICS, INC.; OXFORD AMHERST LLC
To: PHARMACYCLICS LLC
Reel/Frame 038722/0849 →
MERGER AND CHANGE OF NAME Recorded Jul 16, 2015
From: PHARMACYCLICS, INC.; OXFORD AMHERST LLC
To: PHARMACYCLICS LLC
Reel/Frame 036126/0398 →
MERGER Recorded Jul 16, 2015
From: OXFORD AMHERST CORPORATION
To: PHARMACYCLICS, INC.
Reel/Frame 036126/0377 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 20, 2015
From: BUGGY, JOSEPH
To: AXYS PHARMACEUTICALS, INC.
Reel/Frame 034997/0738 →
RELEASE OF LIEN IN INTELLECTUAL PROPERTY Recorded Jul 26, 2011
From: LB I GROUP INC.
To: ORTHOVITA, INC. (FOR ITSELF AND AS SUCCESSOR BY MERGER TO VITA LICENSING, INC. AND PARTISYN CORP.); ORTHOVITA INTERNATIONAL SERVICES, INC.; VITA SPECIAL PURPOSE CORP.
Reel/Frame 026648/0422 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 13, 2009
From: AXYS PHARMACEUTICALS, INC.
To: PHARMACYCLICS, INC.
Reel/Frame 022529/0676 →
SECURITY AGREEMENT Recorded Aug 3, 2007
From: VITA SPECIAL PURPOSE CORP.
To: LB I GROUP INC.
Reel/Frame 019649/0291 →