Formulation and manufacturing process for Coenzyme Q10 soft gel capsules
A soft gelatine capsule formulation improved manufacturing of Coenzyme Q10, comprising Coenzyme Q10 in a thixotropic gelatine carrier capable of admixing without heating with Coenzyme Q10, and capable of keeping Coenzyme Q10 in suspension at ambient temperature.
1 . A composition comprising Coenzyme Q10 in combination with an antioxidant in a thixatropic gelatine carrier for manufacturing soft gel capsules at a temperature of about 27° C. to about 30° C. containing a stable uniform suspension of Coenzyme Q10.
2 . A composition comprising Coenzyme Q10 and a thixatropic gelatine carrier.
3 . The composition of claim 2 , wherein the thixatropic gelatine carrier is a semi-solid at a temperature of about 23° C. to about 28° C. and becomes fluid when stirred.
4 . The composition of claim 2 , wherein the thixatropic gelatine carrier comprises:
from about 84% to about 95% vegetable oil selected from the group consisting of soybean oil, rapeseed oil, palm oil, and cotton seed oil;
from about 1% to about 9% of a viscosity modifier selected from the group consisting of a glyceryl palmito stearate and glyceryl behenate; and
from about 1% to about 15% of a surface active agent comprising polyglyceryl oleate.
5 . The composition of claim 2 , wherein the amount of Coenzyme Q10 in the composition ranges from 8 to 40% by weight.
6 . A process of manufacturing a composition comprising Coenzyme Q 10, said process comprising the steps of:
(a) stirring a thixatropic gelatine carrier until the thixatropic gelatine carrier is liquefied; and
(b) adding Coenzyme Q10 to the liquefied carrier to form a mixture.
7 . The process of claim 6 , wherein the thixatropic gelatine carrier comprises:
from about 84% to about 95% vegetable oil selected from the group consisting of soybean oil, rapeseed oil, palm oil, and cotton seed oil;
from about 1% to about 9% of a viscosity modifier selected from the group consisting of a glyceryl palmito stearate and glyceryl behenate; and
from about 1% to about 15% of a surface active agent comprising polyglyceryl oleate.
8 . The process of claim 6 , further comprising the step of heating the thixatropic gelatine carrier from about 27° C. to about 30° C. prior to the addition of the Coenzyme Q10.
9 . The process of claim 6 , wherein 30 to 100 mg of the Coenzyme Q10 are in each capsule.
10 . The process of claim 6 , wherein the mixture is cooled from about 23° C. to 28° C.
11 . The process of claim 6 , wherein 50 to 500 mg of the thixatropic gelatine carrier is in each capsule.
12 . A composition, prepared by a process comprising the steps of:
(a) heating a thixatropic gelatine carrier to a temperature that liquefies the carrier;
(b) blending the heated thixatropic gelatine carrier and Coenzyme Q10; and
(c) cooling the blended mixture to a temperature, thereby causing the mixture to form a viscous semi-solid.
13 . The composition prepared by the process of claim 12 , wherein the thixatropic gelatine carrier comprises:
from about 84% to about 95% vegetable oil selected from the group consisting of soybean oil, rapeseed oil, palm oil, and cotton seed oil;
from about 1% to about 9% of a viscosity modifier selected from the group consisting of a glyceryl palmito stearate and glyceryl behenate; and
from about 1% to about 15% of a surface active agent comprising polyglyceryl oleate.
14 . The composition prepared by the process of claim 12 , wherein the thixatropic gelatine carrier is heated from about 27° C. to about 30° C.
15 . The composition prepared by the process of claim 12 , wherein 30 to 100 mg of the Coenzyme Q10 are in each capsule.
16 . The composition prepared by the process of claim 12 , wherein the mixture is cooled from about 23° C. to 28° C.
17 . The composition prepared by the process of claim 12 , wherein 50 to 500 mg of the thixatropic gelatine carrier is in each capsule.
18 . A process of manufacturing a composition comprising Coenzyme Q 10, said process comprising the step of:
(a) mixing a thixatropic gelatine carrier and Coenzyme Q10 to form a mixture.
19 . The process of claim 18 , wherein the thixatropic gelatine carrier comprises:
from about 84% to about 95% vegetable oil selected from the group consisting of soybean oil, rapeseed oil, palm oil, and cotton seed oil;
from about 1% to about 9% of a viscosity modifier selected from the group consisting of a glyceryl palmito stearate and glyceryl behenate; and
from about 1% to about 15% of a surface active agent comprising polyglyceryl oleate.
20 . The process of claim 18 , further comprising the step of heating the mixture from about 27° C. to about 30° C.
21 . The process of claim 18 , wherein 30 to 100 mg of the Coenzyme Q10 are in each capsule.
22 . The process of claim 18 , wherein the mixture is cooled from about 23° C. to 28° C.
23 . The process of claim 18 , wherein 50 to 500 mg of the thixatropic gelatine carrier is in each capsule.