Cerebral perfusion augmentation
Methods are provided for partial aortic occlusion for cerebral perfusion augmentation in patients suffering from global or focal cerebral ischemia. The descending aorta is accessed. A device is then located downstream from the takeoff of the brachiocephalic artery. The device is operated to at least partially obstruct blood flow in the aorta during systole and diastole. A physiologic parameter can be measured. The device can then be adjusted to modify the degree of obstruction based on the measured physiologic parameter.
1. A method for increasing cerebral blood flow, comprising the steps of:
advancing a catheter into the descending aorta, the catheter having a proximal region, a distal region, and an expandable member mounted on the distal region;
locating the expandable member in the abdominal aorta;
expanding the expandable member to partially obstruct blood flow in the aorta during systole and diastole;
measuring a physiologic parameter; and
adjusting the expansion of the expandable member based on the measured physiologic parameter.
2. The method of claim 1 , wherein the physiologic parameter is blood pressure.
3. The method of claim 1 , wherein the physiologic parameter is cerebral blood flow.
4. The method of claim 1 , wherein the expandable member is a balloon.
5. The method of claim 1 , wherein blood flow to the cerebral vasculature increases by at least 20%.
6. A method for increasing cerebral blood flow, comprising the steps of:
advancing a catheter into the descending aorta, the catheter having a proximal region, a distal region, and an expandable member mounted on the distal region;
locating the expandable member in the abdominal or thoracic aorta;
expanding the expandable member to partially obstruct blood flow in the aorta during systole and diastole;
measuring a physiologic parameter; and
adjusting the expansion of the expandable member based on the measured physiologic parameter.
7. The method of claim 6 , wherein the physiologic parameter is blood pressure.
8. The method of claim 6 , wherein the physiologic parameter is cerebral blood flow.
9. The method of claim 6 , wherein the expandable member is a balloon.
10. The method of claim 6 , wherein blood flow to the cerebral vasculature increases by at least 20%.
11. A method for increasing cerebral blood flow, comprising the steps of:
advancing a catheter into the descending aorta, the catheter having a proximal region, a distal region, and an expandable member mounted on the distal region;
locating the expandable member in the aorta inferior to the heart;
expanding the expandable member to partially obstruct blood flow in the aorta during systole and diastole;
measuring a physiologic parameter; and
adjusting the expansion of the expandable member based on the measured physiologic parameter.
12. The method of claim 11 , wherein the physiologic parameter is blood pressure.
13. The method of claim 11 , wherein the physiologic parameter is cerebral blood flow.
14. The method of claim 11 , wherein the expandable member is a balloon.
15. The method of claim 11 , wherein blood flow to the cerebral vasculature increases by at least 20%.
16. A method for increasing cerebral blood flow, comprising the steps of:
advancing a catheter into the descending aorta, the catheter having a proximal region, a distal region, and an expandable member mounted on the distal region;
locating the expandable member in the descending aorta;
expanding the expandable member to partially obstruct blood flow in the aorta during systole and diastole for a sustained period without occluding the aorta;
measuring a physiologic parameter; and
adjusting the expansion of the expandable member based on the measured physiologic parameter.
17. The method of claim 16 , wherein the physiologic parameter is blood pressure.
18. The method of claim 16 , wherein the physiologic parameter is cerebral blood flow.
19. The method of claim 16 , wherein the expandable member is a balloon.
20. The method of claim 16 , wherein blood flow to the cerebral vasculature increases by at least 20%.