Methods and compositions for treating atheroma, tumors and other neoplastic tissue
View Patent ↗Injectible formulations comprising motexafin gadolinium are described herein.
1. An injectible formulation comprising motexafin gadolinium, mannitol, acetic acid, and water, wherein the injectible formulation is pharmaceutically acceptable and stored in a sealed container.
2. The injectible formulation of claim 1 , wherein the injectible formulation has a pH of about 5.4.
3. The injectible formulation of claim 2 , wherein the sealed container comprises a glass vial.
4. The injectible formulation of claim 3 , wherein the sealed container comprises a head space that has been purged with a gas to exclude oxygen.
5. The injectible formulation of claim 4 , wherein the gas comprises nitrogen gas.
6. The injectible formulation of claim 1 , further comprising motexafin lutetium.
7. The injectible formulation of claim 1 , further comprising a cellular metabolite or precursor thereof having a reduction potential more negative than that of molecular oxygen.
8. The injectible formulation of claim 7 , wherein the cellular metabolite is ascorbate.