Bicyclic imino acid derivatives as inhibitors of matrix metalloproteinases

1. A compound of the formula I

wherein,

A is —(C 0 –C 4 )-alkylene;

B, D and E are, independently of each other, are —(C 0 –C 4 )-alkylene or the radical —B1-B2-B3- wherein,

B1 is —(CH 2 ) n —, in which n is the integer zero, 1 or 2,

B3 is —(CH 2 ) m —, in which m is the integer zero, 1 or 2,

with the proviso that the sum of n and m amounts to zero, 1 or 2, and

B2 is

1) —C(O)—

2) —(C 2 –C 4 )-alkenylene,

3) —S(O) o —, wherein o is the integer zero, 1 or 2,

4) —N(R6)-, wherein R6 is hydrogen, methyl or ethyl,

5) —N(R6)-C(Y)—, wherein Y is oxygen or sulfur,

6) —C(Y)—N(R6)-, wherein Y is oxygen or sulfur,

7) —N(R6)-SO 2 —,

8) —SO 2 —N(R6)-,

9) —N(R6)-SO 2 —N(R6)-,

10) —N(R6)-C(Y)—N(R6)-, wherein Y is oxygen or sulfur,

11) —O—C(O)—N(R6)-,

12) —NH—C(O)—O—,

13) —O—,

14) —C(O)—O—,

15) —O—C(O)—,

16) —O—C(O)—O—,

17) —O—CH 2 —C(O)—,

18) —O—CH 2 —C(O)—O—,

19) —O—CH 2 —C(O)—N(R6)-,

20) —C(O)—CH 2 —O—,

21) —O—C(O)—CH 2 —O—,

22) —N(R6)-C(O)—CH 2 —O—,

23) —O—(CH 2 ) n —O—, wherein n is the integer 2 or 3, or

24) —O—(CH 2 ) m —N(R6)-, wherein m is the integer 2 or 3,

25) —N(R6)-(CH 2 ) m —O—, wherein m is the integer 2 or 3,

26) —N(R6)-N(R6)-,

27) —N═N—,

28) —N(R6)-CH═N—,

29) —N═CH—N(R6)-,

30) —N(R6)-C(R7)=N—, wherein R7 is —NH—R6,

31) —N═C(R7)-N(R6)-, wherein R7 is —NH—R6, or

32) —(C 2 –C 6 )-alkynylene;

ring 1, ring 2 and ring 3, independently of each other, are

1) a covalent bond,

2) —(C 6 –C 14 )-aryl, that is unsubstituted or substituted, independently of each other, one, two or three times by G, as defined below,

3) 4- to 5-membered Het ring, that is unsubstituted or substituted, independently of each other, one, two or three times by G, or

4) 6-membered Het ring, that contains 1 heteroatom selected from the group consisting of N, O and S, and that is unsubstituted or substituted, independently of each other, one, two or three times by G;

ring 4 is

1) —(C 6 –C 14 )-aryl, that is unsubstituted or substituted, independently of each other, one, two or three times by G,

2) 4- to 5-membered Het ring, that is unsubstituted or substituted, independently of each other, one, two or three times by G,

3) 6-membered Het ring, that contains 1 heteroatom selected from the group consisting of N, O and S, and that is unsubstituted or substituted, independently of each other, one, two or three times by G; or

4)

 that is unsubstituted or substituted once by G;

G is

1) hydrogen,

2) halogen,

3) ═O,

4) —(C 1 –C 6 )-alkyl, that is unsubstituted or substituted, one, two or three times, by halogen, —(C 3 –C 6 )-cycloalkyl, —(C 2 –C 6 )-alkynyl, —(C 6 –C 14 )-aryl or a Het ring,

5) —(C 6 –C 14 )-aryl,

6) a Het ring,

7) —C(O)—O—R10, wherein, R10 is

a) —(C 1 –C 6 )-alkyl, that is unsubstituted or substituted, one or two times by —(C 3 –C 6 )-cycloalkyl, —(C 2 –C 6 )-alkynyl, —(C 6 –C 14 )-aryl or a Het ring, or

b) —(C 6 –C 14 )-aryl, or

c) a Het ring,

8) —C(S)—O—R10,

9) —C(O)—NH—R11, wherein R11 is

a) —(C 1 –C 6 )-alkyl, that is unsubstituted or substituted, one or two times by —(C 3 –C 6 )-cycloalkyl, —(C 2 –C 6 )-alkynyl, —(C 6 –C 14 )-aryl or a Het ring, or

b) —(C 6 –C 14 )-aryl, or

c) a Het ring,

10) —C(S)—NH—R11,

11) —O—R12, wherein R12 is

a) hydrogen,

b) —(C 1 –C 6 )-alkyl, that is unsubstituted or substituted, one, two or three times, by halogen, —(C 3 –C 6 )-cycloalkyl, —(C 2 –C 6 )-alkynyl,

 —(C 6 –C 14 )-aryl or a Het ring,

c) —(C 6 –C 14 )-aryl,

d) a Het ring,

e) —C(O)—O—R13, wherein, R13 is

i) —(C 1 –C 6 )-alkyl, that is unsubstituted or substituted, one or two times by —(C 3 –C 6 )-cycloalkyl, —(C 2 –C 6 )-alkynyl, —(C 6 –C 14 )-aryl, or a Het ring, or

ii) —(C 6 –C 14 )-aryl, or

iii) a Het ring,

f) —C(S)—O—R13,

g) —C(O)—NH—R14, wherein R14 is

i) —(C 1 –C 6 )-alkyl, that is unsubstituted or substituted, one or two times by —(C 3 –C 6 )-cycloalkyl, —(C 2 –C 6 )-alkynyl,

 —(C 6 –C 14 )-aryl or a Het ring, or

ii) —(C 6 –C 14 )-aryl, or

iii) a Het ring, or

h) —C(S)—NH—R14,

12) —C(O)—R10,

13) —S(O) p —R12, wherein p is the integer zero, 1 or 2,

14) —NO 2 ,

15) —CN, or

16) —N(R15)-R12, wherein R15 is

i) hydrogen,

ii) —(C 1 –C 6 )-alkyl, or

iii) —SO 2 —(C 1 –C 6 )-alkyl, wherein the alkyl is unsubstituted or substituted, one or two times by —(C 3 –C 6 )-cycloalkyl, —(C 2 –C 6 )-alkynyl, —(C 6 –C 14 )-aryl or a Het ring, or

17) —SO 2 —N(R12)-R1, wherein, R1 is defined as below;

X is —OH or —NH—OH;

n1 is 2;

n2 is 3;

and

R1, R2, R3, R4 and R5 are identical or different and are, independently of each other,

1) hydrogen,

2) —(C 1 –C 6 )-alkyl, that is unsubstituted or substituted, one or two times by —(C 3 –C 6 )-cycloalkyl, —(C 2 –C 6 )-alkynyl, —(C 6 –C 14 )-aryl or a Het ring,

3) —C(O)—O—R8, wherein R8 is

i) hydrogen,

ii) —(C 1 –C 6 )-alkyl, that is unsubstituted or substituted, one or two times by —(C 3 –C 6 )-cycloalkyl, —(C 2 –C 6 )-alkynyl, —(C 6 –C 14 )-aryl or a Het ring, or substituted one, two, three, four or fives times, by fluorine, or

iii) —(C 6 –C 14 )-aryl or a Het ring,

4) —O—R8, or

5) —(C 3 –C 6 )-cycloalkyl; or

a stereoisomer or a mixture of stereoisomer thereof in any ratio, or a physiologically tolerable salt thereof.

2. The compound according to claim 1 wherein,

A is —(C 0 –C 4 )-alkylene;

ring 1, ring 2 and ring 3, are identical or different and are, independently of each other,

1) —(C 6 –C 14 )-aryl selected from the group consisting of phenyl and naphthyl, that is unsubstituted or substituted, independently of each other, one, two or three times, by G, or

2) 4- to 6-membered Het ring selected from the group consisting of azetidinyl, dihydrofuranyl, dioxolyl, furanyl, furazanyl, imidazolidinyl, imidazolinyl, imidazolyl, isothiazolidinyl, 2-isothiazolinyl, isothiazolyl, isoxazolyl, isoxazolidinyl, 2-isoxazolinyl, oxadiazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl, 1,3,4-oxadiazolyl, oxazolidinyl, oxazolyl, oxothiolanyl, piperidinyl, pyranyl, pyroazolidinyl, pyrazolinyl, pyrazolyl, pyridinyl, pyridyl, pyrrolidinyl, pyrrolinyl, 2H-pyrrolyl, pyrrolyl, tetrahydrofuranyl, tetrahydropyridinyl, 1,2,3-thiadiazolyl, 1,2,4-thiadiazolyl, 1,2,5-thiadiazolyl, 1,3,4-thiadiazolyl, thiazolyl, thienyl, and thiophenyl, that is unsubstituted or substituted, independently of each other, one, two or three times, by G;

ring 4 is

1) —(C 6 –C 14 )-aryl selected from the group consisting of phenyl, naphthyl, 1-naphthyl, 2-naphthyl, anthryl and fluorenyl, that is unsubstituted or substituted, independently of each other, one, two or three times, by G,

2) 4- to 6-membered Het ring selected from the group consisting of azetidinyl, dihydrofuranyl, dioxolyl, furanyl, furazanyl, imidazolidinyl, imidazolinyl, imidazolyl, isothiazolidinyl, 2-isothiazolinyl, isothiazolyl, isoxazolyl, isoxazolidinyl, 2-isoxazolinyl, oxadiazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl, 1,3,4-oxadiazolyl, oxazolidinyl, oxazolyl, oxothiolanyl, piperidinyl, pyranyl, pyroazolidinyl, pyrazolinyl, pyrazolyl, pyridinyl, pyridyl, pyrrolidinyl, pyrrolinyl, 2H-pyrrolyl, pyrrolyl, tetrahydrofuranyl, tetrahydropyridinyl, 1,2,3-thiadiazolyl, 1,2,4-thiadiazolyl, 1,2,5-thiadiazolyl, 1,3,4-thiadiazolyl, thiazolyl, thienyl, and thiophenyl, that is unsubstituted or substituted, independently of each other, one, two or three times, by G, or

3)

 that is unsubstituted or substituted once by G;

G is

1) —C(O)—NH—R11, wherein R11 is

a) —(C 1 –C 6 )-alkyl, that is unsubstituted or substituted, once or twice, by —(C 3 –C 6 )-cycloalkyl, —(C 2 –C 6 )-alkynyl, —(C 6 –C 14 )-aryl or a Het ring,

b) —(C 6 –C 14 )-aryl, or

c) a Het ring,

2) —O—R12, wherein R12 is

a) hydrogen,

b) —(C 1 –C 6 )-alkyl, that is unsubstituted or substituted, one, two or three times, by halogen, —(C 3 –C 6 )-cycloalkyl, —(C 2 –C 6 )-alkynyl, —(C 6 -C, 4 )-aryl or a Het ring,

c) —(C 6 –C 14 )-aryl,

d) a Het ring,

e) —C(O)—O—R13, wherein R13 is

 i) —(C 1 –C 6 )-alkyl, that is unsubstituted or substituted, one or two times, by —(C 3 –C 6 )-cycloalkyl, —(C 2 –C 6 )-alkynyl, —(C 6 –C 14 )-aryl, or a Het ring, or

 ii) —(C 6 –C 14 )-aryl, or

 iii) a Het ring.

3. The compound according to claim 1 , wherein,

B, D and E are identical or different and are, independently of each other, —(C 0 –C 4 )-alkylene or the radical —B1-B2-B3- wherein,

B1 is —(CH 2 ) n —, wherein n is the integer zero, 1 or 2,

B3 is —(CH 2 ) m —, wherein m is the integer zero, 1 or 2,

 with the proviso that the sum of n and m amounts to zero, 1 or 2, and

B2 is

1) —C(O)—

2) ethenylene,

3) —S—,

4) —N(R6)-C(O)—, wherein R6 is hydrogen, methyl or ethyl,

5) —C(O)—N(R6)-,

6) —O—, or

7) ethynylene;

ring 1, ring 2 and ring 3 are identical or different and are, independently of each other,

1) —(C 6 –C 14 )-aryl selected from the group consisting of phenyl and naphthyl, that is unsubstituted or substituted, independently of each other, one or two times, by G, or

2) 4- to 6-membered Het ring selected from the group consisting of dihydrofuranyl, furanyl, pyridinyl, pyrrolyl, thiadiazolyl, thiazolyl and thiophenyl, that is unsubstituted or substituted, independently of each other, one or two times, by G;

ring 4 is

1) —(C 6 –C 14 )-aryl selected from the group consisting of phenyl and naphthyl, that is unsubstituted or substituted, independently of each other, one or two times, by G,

2) 4- to 6-membered Het ring selected from the group consisting of dihydrofuranyl, furanyl, piperidinyl, pyridinyl, pyrrolyl, pyrrolidinyl, thiazolyl and thiophenyl, that is unsubstituted or substituted, independently of each other, one or two times, by G, or

3)

 that is unsubstituted or substituted once by G;

G is 1) hydrogen,

2) Br, Cl or F,

3) —(C 1 –C 4 )-alkyl, that is unsubstituted or substituted one or two times by F, phenyl, —C 3 -cycloalkyl or a Het ring,

4) phenyl,

5) a Het ring,

6) —C(O)—O—R10, wherein R10 is

a) —(C 1 –C 6 )-alkyl, that is unsubstituted or substituted, one or two times, by cyclopropyl, phenyl or a Het ring,

b) phenyl, or

c) a Het ring,

7) —C(O)—NH—R11, wherein R11 is

a) —(C 1 –C 6 )-alkyl, that is unsubstituted or substituted, one or two times, by cyclopropyl, phenyl or a Het ring,

b) phenyl, or

c) a Het ring,

8) —O—R12, wherein R12 is

a) hydrogen,

b) —(C 1 –C 6 )-alkyl, that is unsubstituted or substituted, one, two or three times by halogen, cyclopropyl, phenyl or a Het ring,

c) phenyl,

d) a Het ring,

e) —C(O)—O—R13, wherein R13 is

 i) —(C 1 –C 6 )-alkyl, that is unsubstituted or substituted, one or two times, by cyclopropyl, phenyl or a Het ring, or

ii) phenyl, or

iii) a Het ring,

f) —C(S)—O—R13, or

g) —C(O)—NH—R14, wherein R14 is

 i) —(C 1 –C 6 )-alkyl, that is unsubstituted or substituted, one or two times, by phenyl or a Het ring, or

 ii) phenyl or

 a Het ring,

9) —C(O)—R10,

10) —S(O) p —R12, wherein p is the integer 1 or 2,

11) —NO 2 ,

12) —CN, or

13) —N(R15)-R12, wherein R15 is

i) hydrogen, or

ii) (C 1 –C 6 )-alkyl;

R1, R2 and R3 are hydrogen; and

R4 and R5 are identical or different and are, independently of each other,

1) hydrogen,

2) methyl or ethyl, or

3) —OH.

4. The compound according to claim 1 , wherein,

B, D and E are identical or different and are, independently of each other, —(C 0 –C 4 ) -alkylene or the radical —B1-B2-B3- wherein,

B1 is —(CH 2 ) n —, wherein n is the integer zero, 1 or 2,

B3 is —(CH2) m —, wherein m is the integer zero, 1 or 2,

with the proviso that the sum of n and m amounts to zero, 1 or 2, and

B2 is

1) ethenylene, or

2) ethynylene;

ring 1, ring 2 and ring 3 are identical or different and are, independently of each other,

2) phenyl, that is unsubstituted or substituted, independently of each other, one or two times, by G, or

3) 4- to 6-membered Het ring selected from consisting of dihydrofuranyl, furanyl, piperidinyl, pyridinyl, pyrrolyl, thiazolyl and thiophenyl, that is unsubstituted or substituted, independently of each other, one or two times, by G;

ring 4 is

1) phenyl, that is unsubstituted or substituted, independently of each other, one or two times, by G,

2) 4- to 6-membered Het ring selected from the group consisting of dihydrofuranyl, furanyl, piperidinyl, pyridinyl, pyrimidinyl, pyridothiophenyl, pyrrolyl, pyrrolidinyl, thiazolyl and thiophenyl, that is unsubstituted or substituted, independently of each other, one or two times, by G, or

3)

 that is unsubstituted or substituted once by G;

G is

1) hydrogen,

2) Br, Cl or F,

3) —(C 1 –C 4 )-alkyl, that is unsubstituted or substituted one, two or three times, by

 Br, Cl, F, —C 3 -Cycloalkyl, phenyl or a Het ring,

4) phenyl,

5) a Het ring,

6) —C(O)—O—R10, wherein R10 is

a) —(C 1 –C 6 )-alkyl, that is unsubstituted or substituted, one or two times, by cyclopropyl, phenyl or a Het ring,

b) phenyl, or

c) a Het ring,

7) —C(O)—NH—R11, wherein R11 is

a) —(C 1 –C 6 )-alkyl, that is unsubstituted or substituted, one or two times, by cyclopropyl, phenyl or a Het ring,

b) phenyl or naphthyl, or

c) a Het ring,

8) —O—R12, wherein R12 is

a) hydrogen,

b) —(C 1 –C 6 )-alkyl, that is unsubstituted or substituted, one, two or three times, by halogen, cyclopropyl, phenyl or a Het ring,

c) phenyl,

d) a Het ring,

e) —C(O)—O—R13, wherein R13 is

 e)1) —(C 1 –C 6 )-alkyl, that is unsubstituted or substituted, one or two times, by cyclopropyl, phenyl, naphthyl, or a Het ring, or

 e)2) phenyl, or

 e)3) a Het ring,

f) —C(S)—O—R13, or

g) —C(O)—NH—R14, wherein R14 is

 i) —(C 1 –C 6 )-alkyl, that is unsubstituted or substituted, one or two times, by phenyl or a Het ring, or

 ii) phenyl, or

 iii) a Het ring,

9) —C(O)—R10,

10) —S(O) p —R12, wherein p is an integer 1 or 2,

11) —NO 2 ,

12) —CN, or

13) —N(R15)-R12, wherein R15 is

i) hydrogen, or

ii) —(C 1 –C 6 )-alkyl;

X is —OH or —NH—OH;

and

R1, R2, R3, R4 and R5 are hydrogen.

5. The compound according to claim 1 , wherein,

A is a covalent bond or —CH 2 —CH 2 —;

B, D and E are identical or different and are, independently of each other, —(C 0 –C 4 )-alkylene or

the radical —B1-B2-B3- wherein,

B1 is —(CH 2 ) n —, wherein n is the integer zero, 1 or 2,

B3 is —(CH2) m —, wherein m is the integer zero, 1 or 2,

 with the proviso that the sum of n and m amounts to zero, 1 or 2, and

B2 is

1) —C(O)—

2) —(C 2 –C 4 )-alkynylene,

3) —S(O) o —, wherein o is the integer zero or 1,

4) —N(R6)-C(Y)—, wherein Y is oxygen and R6 is hydrogen,

5) —C(Y)—N(R6)-, wherein Y is oxygen and R6 is hydrogen, or

6) —O—;

ring 1, ring 2 and ring 3 are identical or different and are, independently of each other,

1) phenyl, that is unsubstituted or substituted, independently of each other, one or two times, by G, or

2) 4- to 6-membered Het ring selected from consisting of furanyl, pyridinyl, and thiophenyl, that is unsubstituted or substituted, independently of each other, one or two times, by G; or

ring 4 is

1) phenyl, that is unsubstituted or substituted, independently of each other, one or two times, by G,

2) 4- to 6-membered Het ring selected from the group consisting of furanyl, piperidinyl, pyridinyl, pyrrolyl, pyrrolidinyl, thiazolyl and thiophenyl, that is unsubstituted or substituted, independently of each other, one or two times, by G, or

3)

 that is unsubstituted or substituted once by G;

G is 1) hydrogen,

2) Br, Cl or F,

3) —(C 1 –C 4 )-alkyl, that is unsubstituted or substituted one, two or three times, by Br, Cl, F, —C 3 -cycloalkyl, phenyl or a Het ring,

4) phenyl,

5) a Het ring,

6) —C(O)—O—R10, wherein R10 is

a) —(C 1 –C 6 )-alkyl, that is unsubstituted or substituted, one or two times, by cyclopropyl, phenyl or a Het ring,

b) phenyl, or

c) a Het ring,

7) —C(O)—NH—R11, wherein R11 is

a) —(C 1 –C 6 )-alkyl, that is unsubstituted or substituted, one or two times, by cyclopropyl, phenyl or a Het ring,

b) phenyl, or

c) a Het ring,

11) —O—R12, wherein R12 is

a) hydrogen,

b) —(C 1 –C 6 )-alkyl, that is unsubstituted or substituted, one, two or three times, by halogen, cyclopropyl, phenyl or a Het ring,

c) phenyl,

d) a Het ring,

e) —C(O)—O—R13, wherein R13 is

i) —(C 1 –C 6 )-alkyl, that is unsubstituted or substituted, one or two times, by cyclopropyl, phenyl or a Het ring, or

ii) phenyl, or

iii) a Het ring,

f) —C(S)—O—R13,

g) —C(O)—NH—R14, wherein R14 is

i) —(C 1 –C 6 )-alkyl, that is unsubstituted or substituted, one or two times, by phenyl or a Het ring, or

ii) phenyl, or

iii) a Het ring,

9) —C(O)—R10,

10) —S(O) p —R12, wherein p is the integer zero, 1 or 2,

11) —NO 2 ,

12) —CN, or

13) —N(R15)-R12, wherein R15 is

i) hydrogen, or

ii) —(C 1 –C 6 )-alkyl;

X is —NH—OH;

and

R1, R2, R3, R4 and R5 are hydrogen.

6. The compound according to claim 1 , which is:

2-(4′-nitrobiphenyl-4-sulfonyl)decahydroisoquinoline-1-(N-hydroxy)carboxamide;

2-(4′-chlorobiphenyl-4-sulfonyl)decahydroisoquinoline-1-carboxylic acid;

2-(4′-chlorobiphenyl-4-sulfonyl)decahydroisoquinoline-1-(N-hydroxy)carboxamide;

2-(6-phenoxypyridine-3-sulfonyl)decahydroisoquinoline-1-carboxylic acid trifluoroacetate;

2-(6-phenoxypyridine-3-sulfonyl)decahydroisoquinoline-1-(N-hydroxy)carboxamide trifluoroacetate;

2-[2-(4′-chlorobiphenyl-4-yl)ethanesulfonyl]decahydroisoquinoline-1-carboxylic acid;

2-[2-(4′-chlorobiphenyl-4-yl)ethanesulfonyl]decahydroisoquinoline-1-(N-hydroxy)carboxamide;

2-[4-(pyridin-4-yloxy)benzenesulfonyl]decahydroisoquinoline-1-carboxylic acid trifluoroacetate;

2-[4-(pyridin-4-yloxy)benzenesulfonyl]decahydroisoquinoline-1-(N-hydroxy)carboxamide trifluoroacetate;

2-[4-(4-methoxyphenoxy)benzenesulfonyl]decahydroisoquinoline-1-carboxylic acid;

2-[4-(4-methoxyphenoxy)benzenesulfonyl]decahydroisoquinoline-1-(N-hydroxy)carboxamide;

2-{4-[4-(2,2,2-trifluoroethoxy)phenoxy]benzenesulfonyl}decahydroisoquinoline-1-carboxylic acid;

2-{4-[4-(2,2,2-trifluoroethoxy)phenoxy]benzenesulfonyl}decahydroisoquinoline-1-(N-hydroxy)carboxamide;

2-[4′-(2,2,2-trifluoroethoxy)biphenyl-4-sulfonyl]decahydroisoquinoline-1-carboxylic acid;

2-(4′-isopropoxycarbonylaminobiphenyl-4-sulfonyl)decahydroisoquinoline-1-carboxylic acid;

[4′-(1-hydroxycarbamoyloctahydroisoquinoline-2-sulfonyl)biphenyl-4-yl]carboxamide isopropyl ester;

2-[4′-(2,2,2-trifluoroethoxy)biphenyl-4-sulfonyl]decahydroisoquinoline-1-(N-hydroxy)carboxamide;

2-(4′-trifluoromethoxybiphenyl-4-sulfonyl)decahydroisoquinoline-1-(N-hydroxy)carboxamide;

2-[4-(4-fluorophenoxy)benzenesulfonyl]decahydroisoquinoline-1-(N-hydroxy)carboxamide;

2-[4-(4-trifluoromethoxyphenoxy)benzenesulfonyl]decahydroisoquinoline-1-(N-hydroxy)carboxamide;

2-[4-(4-trifluoromethoxyphenoxy)benzenesulfonyl]decahydroisoquinoline-1-carboxylic acid; 2-(biphenyl-4-sulfonyl)decahydroisoquinoline-1-(N-hydroxy)carboxamide;

2-(biphenyl-4-sulfonyl)decahydroisoquinoline-1-carboxylic acid;

2-[4-(4-cyanophenoxy)benzenesulfonyl]decahydroisoquinoline-1-(N-hydroxy)carboxamide;

2-(dibenzofuran-2-sulfonyl)decahydroisoquinoline-1-carboxylic acid;

2-(dibenzofuran-2-sulfonyl)decahydroisoquinoline-1-(N-hydroxy)carboxamide; or

2-[4-(4-fluorophenoxy)benzenesulfonyl]-6-methoxydecahydroisoquinoline-1-(N-hydroxy)carboxamide.

7. A process for the preparation of a compound according to claim 1 , comprising,

a) reacting a compound of formula IV,

 wherein, Re is hydrogen, or an ester-protecting group,

 with a compound of formula (V),

 wherein, Rz is chlorine, imidazoyl or OH,

in the presence of a base, or following silylation with a suitable silylating agent, or using a suitable dehydrating agent, when Rz=OH, to give a compound of the formula (VI),

 wherein, Re is an ester-protecting group, and

b) reacting a compound of the formula (VI), prepared as described in a), with a solution of alkali such as NaOH or LiOH, and then treating the product with acid, to give the carboxylic acid according to formula (I), wherein, X=OH, corresponding to a compound of formula (VII), with modifications to one of rings1, ring2, ring3 or ring4, also previously made, where appropriate, or

converting the ester-protecting group, by treating it with a mineral acid, such as hydrochloric acid, to yield a free carboxylic acid of the formula (VII),

 and then, converting a compound of formula (VII) into the hydroxamic acid, wherein, X=NH—OH, of formula (I), or

c) separating the compound of formula (I), prepared as described in a), or a suitable precursor to formula (I), to give enantiomerically pure compounds of formula (I), by,

i) forming a salt using enantiomerically pure acids or bases,

ii) performing chromatography using chiral stationary phases, or

iii) derivatizing the compound of formula (I) using chiral, enantiomerically pure compounds, such as amino acids, and then, separating resulting diastereomers, and eliminating chiral auxiliary groups, or

d) isolating the compound of the formula (I), prepared as described in procedures b) or c),

i) in free form, or,

ii) when acid or basic groups are present, converting the compound of formula (I) into physiologically tolerated salts.

8. A pharmaceutical preparation according to claim 1 , comprising a pharmaceutically effective amount of at least one compound of formula (I), in all its stereoisomeric forms and mixtures thereof, in any ratio, or its physiologically tolerated salt, and a pharmaceutically acceptable carrier.