Medical devices employing triazine compounds and compositions thereof
View Patent ↗The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
1. A stent comprising a compound disposed on or within the stent, wherein the compound is:
2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,35]triazin-2-ylamino]-methyl}-cyclopentanone,
N-[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-guanidine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-(1-methyl-pyrrolidin-2-yl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-(tetrahydro-furan-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
1-(2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-pyrrolidin-1-yl)-ethanone,
2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-pyrrolidine-1-carboxylic acid methyl ester,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-pyrrolidin-2-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(2-ethyl-cyclopentylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(2-ethyl-pyrazolidin-1-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-(1-methyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-3-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-imidazol-1-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-6-(1-ethyl-pyrrolidin-2-ylmethoxy)-N′-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4-diamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-6-(hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)-[1,3,5]triazine-2,4-diamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-N′-methyl-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-6-(pyrrolidin-2-ylmethoxy)-[1,3,5]triazine-2,4-diamine,
N-Cyclohexylmethyl-N-(1-ethyl-piperidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
1-Ethyl-pyrrolidine-2-carboxylic acid [4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-amide,
Pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-[4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxyphenylamino)-[1,3,5]triazin-2-yl] ester,
Pyrrolidine-2-carboxylic acid 4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl ester,
N-(3-Chloro-4-methoxy-phenyl)-N′-cyclohexylmethyl-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-(3-Bromo-4-methoxy-phenyl)-N′-cyclohexylmethyl-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(4-methoxy-3-nitro-phenyl)-[1,3,5]triazine-2,4,6-triamine,
5-[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(2-methyl-pentylamino)[1,3,5]triazin-2-ylamino]-2-methoxy-benzenesulfonic acid,
5-{4-(Cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino)-2-methoxy-benzonitrile,
4-{4-(Cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino)-2-fluoro-phenol,
Sodium; 2-chloro-4-{4-(cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-phenylate,
N-(3-Chloro-4-ethoxy-phenyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(2-methyl-phenyl)-[1,3,5]triazine-2,4,6-triamine,
Sodium; 4-{4-(cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-yl methyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-phenolate,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxymethoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methylsulfanylethoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methanesulfanylmethoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methanesulfonylmethoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methylsulfanyl-phenyl)-[1,3,5]triazine-2,4,6-triamine,
4-{4-(Cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-benzenethiol,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-N″-methyl-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N′-Methyl-N″-pyrrolidin-2-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-6-(tetrahydro-pyrrolo[1,2-c]imidazol-2-yl)-[1,3,5]triazine-2,4-diamine,
Phosphoric acid mono-(4-{4-(cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-phenoxymethyl) ester,
Phosphoric acid mono-(4-{4-(cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-phenyl) ester,
Phosphoric acid mono-(2-chloro-4-{4-(cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-phenoxymethyl) ester,
N-Cyclohexy[methyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methylamino-phenyl)-[1,3,5]triazine-2,4,6-triamine,
Acetic acid 4-{4-(cyclohexylmethylamino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-phenyl ester,
N-(4-Amino-3-fluoro-phenyl)-N′-cyclohexylmethyl-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(4-dimethylamino-3-fluoro-phenyl)-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-(4-Amino-3-chloro-phenyl)-N′-cyclohexylmethyl-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-isopropoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(4-cyclopropoxy-3-fluoro-phenyl)-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-(3-Chloro-4-cyclopropoxy-phenyl)N′-Cyclohexylmethyl-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(4-ethyl-3-fluoro-phenyl)-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methyl-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(3-Chloro-4-methyl-phenyl)-N′-cyclohexylmethyl-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4trifluoromethoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(4-methoxy-3-trifluoromethyl-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(3-Chloro-4-trifluoromethoxy-phenyl)-N′-cyclohexylmethyl-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-ethyl-oxazolidin-4-ylmethyl)-N″-(4-trifluoromethoxy-3-trifluoromethyl-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3,5-dichloro-4-methyl-phenyl)-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3,5-dichloro-4-methoxy-phenyl)-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3,5-difluoro-4-methoxy-phenyl)-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
4-{4-(Cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2,6-difluoro-phenyl,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(4-fluoro-5methoxy-pyridin-2-yl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(5-fluoro-6methoxy-pyridin-3-yl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(8-fluoro-chroman-6-yl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-6-(3-fluoro-4-methoxy-phenoxy)-[1,3,5]triazine-2,4-diamine,
6-(4-Amino-3-fluoro-phenoxy)-N-cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4-diamine,
6-(4-Amino-2-fluoro-phenoxy)-N-cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4-diamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N-(3-fluoro-4-methoxy-phenyl)-N″-(tetrahydro-pyran-4-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-6-(3-fluoro-4-methoxy-phenoxy)-N′-piperidin-4-ylmethyl-[1,3,5]triazine-2,4-diamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-thiomorpholin-4-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(1,1-Dioxo-1 lambda*6*-thiomorpholin-4-ylmethyl)-N′-1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-(tetrahydro-thiopyran-4-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1,1-Dioxo-hexahydro-1 lambda*6*-thiopyran-4-ylmethyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Benzyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-(4-methoxy-benzyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-(4-methyl-benzyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-(4-nitro-benzyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(4-fluoro-benzyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclopenty[methyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohex-2-enylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclopropylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
′3-{[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-cyclopentanol,
N-(3-Amino-cyclopentylmethyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-benzyl)-[1,3,5]triazine-2,4,6-triamine,
N-(3-Amino-cyclopentylmethyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
2-{[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-cyclopentanol,
N-(2-Amino-cyclopentylmethyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-(4-methyl-cyclohexylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-(2-methyl-cyclohexylmethyl)-[1,3,5]triazine-2,4,6-triamine,
2-{[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-cyclohexanol,
3-{[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-cyclohexanol,
4-{[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-cyclohexanol,
N-(4-Amino-cyclohexylmethyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(3-Amino-cyclohexylmethyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cycloheptylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Bicyclo[2.2.1]hept-2-yl-N′-cyclohexylmethyl-N″-(3-fluoro-4-methoxyphenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Bicyclo[2.2.2]oct-2-yl-N′-cyclohexylmethyl-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Aza-bicyclo[2.2.2]oct-3-yl)-N′-cyclohexylmethyl-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Cyclohexyl-1-methyl-ethyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-(tetrahydro-thiophen-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-(tetrahydro-furan-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-furan-2-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-thiophen-2-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-ethoxy-phenyl)-N″-(1H-pyrrol-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-nethoxy-phenyl)-N″-(1-methyl-1H-pyrrol-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(2,3-dihydro-1H-indol-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(2-dimethylamino-ethyl)-N″-(3-fluoro-4-methoxyphenyl)-[1,3,5]triazine-2,4,6-triamine,
Pyrrolidine-2-carboxylic acid [4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-amide,
Pyrrolidine-2-carboxylic acid 4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl ester,
1-Methyl-pyrrolidine-2-carboxylic acid [4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-amide,
2-[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-hexahydro-pyrrolo[1,2-c]imidazol-1-one,
1-[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-pyrrolidine-2,5-dione,
1-[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-imidazolidine-2,4-dione,
3-[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-thiazolidine-2,5-dione,
2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-1-ethyl-1-methyl-pyrrolidinium; chloride,
1-Acetyl-2-{[4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-1-ethyl-pyrrolidinium; chloride,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-furan-2-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-thiophen-2-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(3-Chloro-4-methoxy-phenyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-thiophen-2-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(3-Chloro-4-methoxy-phenyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-oxazol-5-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(3-Chloro-4-methoxy-phenyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-imidazol-1-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-imidazol-1-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-pyrimidin-4-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(2-Amino-pyrimidin-4-ylmethyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
5-{[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-thiazolidine-2,4-dione,
5-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-thiazolidine-2,4-dione,
5-{[4-(3-Chloro-4-methoxy-phenylamino)-6-(cyclohexylmethyl-amino)-[1,3,5]triazin-2-ylamino]-methyl}-thiazolidine-2,4-dione,
5-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-hydroxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-thiazolidine-2,4-dione,
5-{[4-(3-Chloro-4-hydroxy-phenylamino)-6-(cyclohexylmethyl-amino)-[1,3,5]triazin-2-ylamino]-methyl}-thiazolidine-2,4-dione,
Sodium; 4-{4-(cyclohexylmethyl-amino)-6-[(2,4-dioxo-thiazolidin-5-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-phenylate,
2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-1-ethyl-pyrrolidinium; chloride,
2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-1-ethyl-pyrrolidinium; bromide,
5-{4-(Cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-methoxy-benzoic acid,
Sodium; 5-{4-(cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-methoxy-benzoate,
3-(2-{2-[2-(2-Hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-propionic acid-{4-(cyclohexylmethyl-amino)-6-[(1 ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-phenyl ester,
3-(2-{2-[2-(2-Methoxy-ethoxy)-ethoxy]-ethoxy)-ethoxy)-propionic acid 4-{4-(cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino)-2-fluoro-phenyl ester,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy)-phenyl)-[1,3,5]triazine-2,4,6-triamine,
.OH2-{2-[2-(4-{4-(Cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-phenoxy)-ethoxy]-ethoxy)-ethanol,
1-(2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl)-pyrrolidin-1-yl)-3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy)-propan-1-one,
1-(2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-pyrrolidin-1-yl)-3-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy)-propan-1-one,
2-(2-{2-[2-(2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-pyrrolidin-1-yl)-ethoxy]-ethoxy}-ethoxy)-ethanol,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-[1-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethyl)-pyrrolidin-2-ylmethyl]-[1,3,5]triazine-2,4,6-triamine,
3-Carboxy-propionate 2-{[4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl)-1-ethyl-pyrrolidinium,
3-Carboxy-acrylate 2-{[4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-1-ethyl-pyrrolidinium,
N-Cyclohexylmethyl-6-(2-dimethylamino-ethoxy)-N′-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4-diamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-6-(thiophen-2-ylmethoxy)-[1,3,5]triazine-2,4-diamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-6-(oxazol-5-ylmethoxy)-[1,3,5]triazine-2,4-diamine,
6-Benzyloxy-N-(1-ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4-diamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-6-(1-methyl-1H-pyrrol-2-ylmethoxy)-[1,3,5]triazine-2,4-diamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-6-(furan-2-ylmethoxy-[1,3,5]triazine-2,4-diamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-6-(thiophen-2-ylmethoxy)-[1,3,5]triazine-2,4-diamine,
6-(Bicyclo[2.2.2]oct-2-yloxy)-N-cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4-diamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-6-(1-methyl-pyrrolidin-2-yloxy)-[1,3,5]triazine-2,4-diamine,
4-[4-[(1-Ethyl-pyrrolidin-2-yl methyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yloxymethyl]-cyclohexanol,
4-[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yloxymethyl]-phenyl,
[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-(4-hydroxy-phenyl)-acetic acid,
Cyclohexyl-[4-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-acetic acid,
[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-phenyl-acetic acid,
6-(2-Amino-1-phenyl-ethoxy)-N1-ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4-diamine,
2-[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-2-phenyl-ethanol,
N-(1-Benzyl-pyrrolidin-2-ylmethyl)N′-cyclohexylmethyl-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
Amino-phenyl-acetic acid 4-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl ester,
Trifluoro-acetate 2-{[4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxyphenylamino)-[1,3,5]triazin-2-ylamino]-methyl)-1-ethyl-pyrrolidinium, or
2-Cyclohexyl-2-[4-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-ethanol, or a stereoisomer, and enantiomer, a diastereomer, a racemic mixture, a salt, or a combination thereof.
2. A stent comprising a composition disposed on or within the stent, the composition comprising a pharmaceutically acceptable carrier and a compound, wherein the compound is selected from:
{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-cyclopentanone,
N-[4-(Cyclohexylmethyl-amino)-6-(3fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-guanidine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-(1-methyl-pyrrolidin-2-yl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-(tetrahydro-furan-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
1-(2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-pyrrolidin-1-yl)-ethanone,
2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-pyrrolidine-1-carboxylic acid methyl ester,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-pyrrolidin-2-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(2-ethyl-cyclopentylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(2-ethyl-pyrazolidin-1-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-(1-methyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-3-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoromethoxy-phenyl)-N″-imidazol-1-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-6-(1-ethyl-pyrolidin-2-ylmethoxy)-N′-(3-fluoromethoxy-phenyl)-[1,3,5]triazine-2,4diamine,
N-Cyclohexylmethyl-N′-(3-fluoromethoxy-phenyl)-6-(hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)-[1,3,5]triazine-2,4-diamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-N′-methyl-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-6-(pyrrolidin-2-ylmethoxy)-[1,3,5]triazine-2,4-diamine,
N-Cyclohexylmethyl-N′-(1-ethyl-piperidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
1-Ethyl-pyrrolidine-2-carboxylic acid [4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-amide,
Pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-[4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxyphenylamino)-[1,3,5]triazin-2-yl]ester,
Pyrrolidine-2-carboxylic acid 4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl ester,
N-(3-Chloro-4-methoxy-phenyl)-N′-cyclohexylmethyl-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-(3-Bromo-4-methoxy-phenyl)-N′-cyclohexylmethyl-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(4-methoxy-3-nitro-phenyl)-[1,3,5]triazine-2,4,6-triamine,
5-[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(2-methyl-pentylamino)[1,3,5]triazin-2-ylamino]-2-methoxy-benzenesulfonic acid,
5-{4-(Cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino)-2-methoxy-benzonitrile,
4-{4-(Cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino)-2-fluoro-phenyl,
Sodium; 2-chloro-4-{4-(cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-phenylate,
N-(3-chloro-4-ethoxy-phenyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(2-methyl-phenyl)-[1,3,5]triazine-2,4,6-triamine,
Sodium; 4-{4-(cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-phenylate,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxymethoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methylsulfanylmethoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methanesulfinylmethoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methanesulfonylmethoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methylsulfanyl-phenyl)-[1,3,5]triazine-2,4,6-triamine,
4-{4-(Cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-benzenethiol,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-N″-methyl-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N′-methyl-N″-pyrrolidin-2-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-6-(tetrahydro-pyrrolo[1,2-c]imidazol-2-yl)-[1,3,5]triazine-2,4-diamine,
Phosphoric acid mono-(4-{4-(cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-phenoxymethyl) ester,
Phosphoric acid mono-(4-{4-(cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-phenyl) ester,
Phosphoric acid mono-(2-chloro-4-{4-(cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[13,5]triazin-2-ylamino}-phenoxymethyl) ester,
N-Cyclohexy[methyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4methylamino-phenyl)-[1,3,5]triazine-2,4,6-triamine,
Acetic acid 4-{4-(cyclohexylmethylamino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-phenyl ester,
N-(4-Amino-3-fluoro-phenyl)-N′-cyclohexylmethyl-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(4-dimethylamino-3-fluoro-phenyl)-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-(4-Amino-3-chloro-phenyl)-N′-cyclohexylmethyl-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-isopropoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N-(4-cyclopropoxy-3-fluoro-phenyl)-N″-1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-(3-Chloro-4-cyclopropoxy-phenyl)N′-Cyclohexylmethyl-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(4-ethyl-3-fluoro-phenyl)-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4methyl-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(3-Chloro-4-methyl-phenyl)-N′-cyclohexylmethyl-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4trifluoromethoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(4-methoxy-3-trifluoromethyl-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(3-Chloro-4-trifluoromethoxy-phenyl)-N′-cyclohexylmethyl-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-ethyl-oxazolidin-4-ylmethyl)-N″-(4-trifluoromethoxy-3-trifluoromethyl-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3,5-dichloro-4-methyl-phenyl)-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3,5-dichloro-4-methoxy-phenyl)-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3,5-difluoro-4-methoxy-phenyl)-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
4-{4-(Cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2,6-difluoro-phenyl,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(4-fluoro-5methoxy-pyridin-2-yl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(5-fluoro-6methoxy-pyridin-3-yl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(8-fluoro-chroman-6-yl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-6-(3-fluoro-4-methoxy-phenoxy)-[1,3,5]triazine-2,4-diamine,
6-(4-Amino-3-fluoro-phenoxy)-N-cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4-diamine,
6-(4-Amino-2-fluoro-phenoxy)-N-cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4-diamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N-(3-fluoromethoxy-phenyl)-N″-(tetrahydro-pyran-4-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-6-(3-fluoro-4-methoxy-phenoxy)-N-piperidin-4-ylmethyl-[1,3,5]triazine-2,4-diamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-thiomorpholin-4-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(1,1-Dioxo-1 lambda*6*-thiomorpholin-4-ylmethyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N-(3-fluoro-4-methoxy-phenyl)-N″-(tetrahydro-thiopyran-4-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1,1-Dioxo-hexahydro-1 lambda*6*-thiopyran-4-ylmethyl)-N′-1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Benzyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-(4-methoxy-benzyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-(4-methyl-benzyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-(4-nitro-benzyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(4-fluoro-benzyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclopenty[methyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohex-2-enylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclopropylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
′3-{[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-cyclopentanol,
N-(3-Amino-cyclopentylmethyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-benzyl)-[1,3,5]triazine-2,4,6-triamine,
N-(3-Amino-cyclopentylmethyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
2-{[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-cyclopentanol,
N-(2-Amino-cyclopentylmethyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-(4-methyl-cyclohexylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-(2-methyl-cyclohexylmethyl)-[1,3,5]triazine-2,4,6-triamine,
2-{[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-cyclohexanol,
3-{[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-cyclohexanol,
4-{[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-cyclohexanol,
N-(4-Amino-cyclohexylmethyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(3-Amino-cyclohexylmethyl)-N′-(1 ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cycloheptylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Bicyclo[2.2.1]hept-2-yl-N′-cyclohexylmethyl-N″-(3-fluoro-4-methoxyphenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Bicyclo[2.2.2]oct-2-yl-N′-cyclohexylmethyl-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Aza-bicyclo[2.2.2]oct-3-yl)-N′-cyclohexylmethyl-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Cyclohexyl-1-methyl-ethyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-(tetrahydro-thiophen-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-(tetrahydro-furan-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-furan-2-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-thiophen-2-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-ethoxy-phenyl)-N″-(1H-pyrrol-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-nethoxy-phenyl)-N″-(1-methyl-1H-pyrrol-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-(1-methyl-1H-pyrrol-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(2,3-dihydro-1H-indol-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(2-dimethylamino-ethyl)-N″-(3-fluoro-4-methoxyphenyl)-[1,3,5]triazine-2,4,6-triamine,
Pyrrolidine-2-carboxylic acid [4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-amide,
Pyrrolidine-2-carboxylic acid 4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl ester,
1-Methyl-pyrrolidine-2-carboxylic acid [4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-amide,
2-[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-hexahydro-pyrrolo[1,2-c]imidazol-1-one,
1-[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-pyrrolidine-2,5-dione,
1-[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-imidazolidine-2,4-dione,
3-[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-thiazolidine-2,5-dione,
2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-1-ethyl-1-methyl-pyrrolidinium; chloride,
1-Acetyl-2-{[4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-1-ethyl-pyrrolidinium; chloride,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-furan-2-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-thiophen-2-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(3-Chloro-4-methoxy-phenyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-thiophen-2-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(3-Chloro-4-methoxy-phenyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-oxazol-5-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(3-Chloro-4-methoxy-phenyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-imidazol-1-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-imidazol-1-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N-(3-fluoro-4-methoxy-phenyl)-N″-pyrimidin-4-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(2-Amino-pyrimidin-4-ylmethyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
5-{[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-thiazolidine-2,4-dione,
5-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-thiazolidine-2,4-dione,
5-{[4-(3-Chloro-4-methoxy-phenylamino)-6-(cyclohexylmethyl-amino)-[1,3,5]triazin-2-ylamino]-methyl}-thiazolidine-2,4-dione,
5-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-hydroxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-thiazolidine-2,4-dione,
5-{[4-(3-Chloro-4-hydroxy-phenylamino)-6-(cyclohexylmethyl-amino)-[1,3,5]triazin-2-ylamino]-methyl}-thiazolidine-2,4-dione,
Sodium; 4-{4-(cyclohexylmethyl-amino)-6-[(2,4-dioxo-thiazolidin-5-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-phenylate,
2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-1-ethyl-pyrrolidinium; chloride,
2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl)-1-ethyl-pyrrolidinium; bromide,
5-{4-(Cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-methoxy-benzoic acid,
Sodium; 5-{4-(cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-methoxy-benzoate,
3-(2-{2-[2-(2-Hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-propionic acid-{4-(cyclohexylmethyl-amino)-6-[(1 ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-phenyl ester,
3-(2-{2-[2-(2-Methoxy-ethoxy)-ethoxy]-ethoxy)-ethoxy)-propionic acid 4-{4-(cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino)-2-fluoro-phenyl ester,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4 {2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy)-phenyl)-[1,3,5]triazine-2,4,6-triamine,
.OH2-{2-[2-(4-{4-(Cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-phenoxy)-ethoxy]-ethoxy)-ethanol,
1-(2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl)-pyrrolidin-1-yl)-3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy)-propan-1-one,
1-(2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoromethoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-pyrrolidin-1-yl)-3-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy)-propan-1-one,
2-(2-{2-[2-(2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-pyrrolidin-1-yl)-ethoxy]-ethoxy}-ethoxy)-ethanol,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-[1-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethyl)-pyrrolidin-2-ylmethyl]-[1,3,5]triazine-2,4,6-triamine,
3-Carboxy-propionate 2-{[4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl)-1-ethyl-pyrrolidinium,
3-Carboxy-acrylate 2-{[4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-1-ethyl-pyrrolidinium,
N-Cyclohexylmethyl-6-(2-dimethylamino-ethoxy)-N′-(3fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4-diamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-6-(thiophen-2-ylmethoxy)-[1,3,5]triazine-2,4-diamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-6-(oxazol-5-ylmethoxy)-[1,3,5]triazine-2,4-diamine,
6-Benzyloxy-N-(1-ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4-diamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-6-(1-methyl-1H-pyrrol-2-ylmethoxy)-[1,3,5]triazine-2,4-diamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-6-(furan-2-ylmethoxy-[1,3,5]triazine-2,4-diamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-6-(thiophen-2-ylmethoxy)-[1,3,5]triazine-2,4-diamine,
6-(Bicyclo[2.2.2]oct-2-yloxy)-N-cyclohexylmethyl-N-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4-diamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-6-(1-methyl-pyrrolidin-2-yloxy)-[1,3,5]triazine-2,4-diamine,
4-[4-[(1-Ethyl-pyrrolidin-2-yl methyl) amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yloxymethyl]-cyclohexanol,
4-[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yloxymethyl]-phenyl,
[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-(4-hydroxy-phenyl)-acetic acid,
Cyclohexyl-[4-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-acetic acid,
[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-phenyl-acetic acid,
6-(2-Amino-1-phenyl-ethoxy)-N-(1-ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4-diamine,
2-[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-2-phenyl-ethanol,
N-(1-Benzyl-pyrrolidin-2-ylmethyl)N′-cyclohexylmethyl-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
Amino-phenyl-acetic acid 4-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl ester,
Trifluoro-acetate 2-{[4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxyphenylamino)-[1,3,5]triazin-2-ylamino]-methyl)-1-ethyl-pyrrolidinium, or
2-Cyclohexyl-2-[4-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-ethanol, or a stereoisomer, an enantiomer, a diastereomer, a racemic mixture, a salt, or a combination thereof.
3. The stent as claimed in claim 2 , wherein the composition further comprises at least one of the following:
a pharmaceutically acceptable auxiliary;
a pharmaceutically acceptable preservative;
a pharmaceutically acceptable excipient; or
any combination thereof.
4. A stent comprising a compound disposed on or within the stent, the compound having the formula
or a stereoisomer, an enantiomer, a diastereomer, a racemic mixture, a salt, or a combination thereof; wherein:
R 1 is selected from
R 2 is selected from
R 3 is selected from —NH 2 ,
5. The stent as claimed in claim 4 , wherein the compound has the formula
or a stereoisomer, an enantiomer, a diastereomer, a racemic mixture, a salt, or a combination thereof; wherein:
R 1 is selected from
6. The stent as claimed in claim 4 , wherein the compound has the formula
or a stereoisomer, an enantiomer, a diastereomer, a racemic mixture, a salt, or a combination thereof; wherein:
R 2 is selected from
7. The stent as claimed in claim 4 , wherein the compound has the formula:
or a stereoisomer, an enantiomer, a diastereomer, a racemic mixture, a salt, or a combination thereof; wherein:
R 3 is selected from —NH 2 ,
8. A stent comprising a composition disposed on or within the stent, the composition comprising a pharmaceutically acceptable carrier and a compound having the formula
or a stereoisomer, an enantiomer, a diastereomer, a racemic mixture, a salt, or a combination thereof; wherein:
R 1 is selected from
R 2 is selected from
R 3 is selected from —NH 2 ,
9. The stent as claimed in claim 8 , wherein the composition further comprises at least one of the following:
a pharmaceutically acceptable auxiliary;
a pharmaceutically acceptable preservative;
a pharmaceutically acceptable excipient; or
any combination thereof.
10. The stent as claimed in claim 8 , wherein the compound has the formula
or a stereoisomer, an enantiomer, a diastereomer, a racemic mixture, a salt, or a combination thereof; wherein:
R 1 is selected from
11. The stent as claimed in claim 8 , wherein the compound has the formula
or a stereoisomer, an enantiomer, a diastereomer, a racemic mixture, a salt, or a combination thereof; wherein:
R 2 is selected from
12. The stent as claimed in claim 8 , wherein the compound has the formula
or a stereoisomer, an enantiomer, a diastereomer, a racemic mixture, a salt, or a combination thereof; wherein:
R 3 is selected from —NH 2 ,
13. A stent comprising a compound disposed on or within the stent, the compound having the formula
or a stereoisomer, an enantiomer, a diastereomer, a racemic mixture, a salt, or a combination thereof; wherein:
R 1 is selected from
R 2 is selected from
R 3 is selected from —NH 2 ,
14. A stent comprising a composition disposed on or within the stent, the composition comprising a pharmaceutically acceptable carrier and a compound according to claim 13 .
15. The stent as claimed in claim 14 , wherein the composition further comprises at least one of the following:
a pharmaceutically acceptable auxiliary;
a pharmaceutically acceptable preservative;
a pharmaceutically acceptable excipient; or
any combination thereof.
16. A stent comprising a compound disposed on or within the stent, the compound having the formula
or a stereoisomer, an enantiomer, a diastereomer, a racemic mixture, a salt, or a combination thereof; wherein:
R 1 is selected from
R 2 is selected from
R 3 is selected from
17. A stent comprising a composition disposed on or within the stent, the composition comprising a pharmaceutically acceptable carrier and a compound according to claim 16 .
18. The stent as claimed in claim 17 , wherein the composition further comprises at least one of the following:
a pharmaceutically acceptable auxiliary;
a pharmaceutically acceptable preservative;
a pharmaceutically acceptable excipient; or
any combination thereof.