Sustained release of superoxide dismutase mimics from implantable of insertable medical devices

1. An implantable or insertable medical device comprising:

a superoxide dismutase mimic selected from a metal-chelate superoxide dismutase mimic and a nitroxide superoxide dismutase mimic; and

a polymeric release region tat controls the release of said superoxide dismutase mimic upon administration to a patient;

wherein the superoxide dismutase mimic is disposed within a polymeric matrix comprising a copolymer comprising an isobutylene monomer and a styrene monomer;

and wherein the medical device is selected from a stent, a catheter, a balloon, a cerebral aneurysm filter coil, an arterio-venous shunt, a guide wire, a vena cava filter, a stent graft, a vascular graft, a myocardial plug, a patch, a pacemaker, a pacemaker lead, and a heart valve.

2. The implantable or insertable medical device of claim 1 , wherein said stent is a vascular stent.

3. The implantable or insertable medical device of claim 1 , wherein said medical device is a vascular medical device.

4. The implantable or insertable medical device of claim 1 , wherein said superoxide dismutase mimic is a nitroxide compound.

5. The implantable or insertable medical device of claim 1 , wherein said superoxide dismutase mimic is a nitroxide compound selected from 2,2,6,6-tetramethylpiperidine-1-yloxy, 4-hydroxytetramethyl-piperidine-1-oxyl and 4-hydroxy-2,2,6,6,-tetramethylpiperidine-1-N-oxyl.

6. The implantable or insertable medical device of claim 1 , wherein said superoxide dismutase mimic is a metal-chelate compound.

7. The implantable or insertable medical device of claim 1 , wherein said superoxide dismutase mimic is a metal-chelate compound selected from metal-pentaazacyclopentadecane compounds, metal-porphine compounds, metal-porphine compounds, metal-desferioxamine compounds, metal-bis(cyclohexylpyridine) compounds and salen-metal compounds.

8. A method for treating a disease or condition of the vasculature comprising implanting or inserting the medical device of claim 1 into the body of a patient.

9. A method for treating a disease or condition of the vasculature comprising implanting or inserting the medical device of claim 1 into the vasculature of a patient.

10. The method of claim 8 , wherein 50% of the total amount of superoxide dismutase mimic that is released into the body from said medical device is released beyond 24 hours after administration.

11. The method of claim 9 , wherein said disease or condition is restenosis.

12. A method of forming the implantable or insertable medical device of claim 1 comprising:

comprising said superoxide dismutase mimic, said copolymer and a solvent;

contacting said solution or dispersion with a medical device; and

removing said solvent to form a superoxide dismutase mimic-containing polymeric matrix on said medical device,

wherein said polymeric matrix controls the release of said superoxide dismutase mimic upon administration to a patient.

13. The method of claim 12 , wherein said superoxide dismutase mimic is a nitroxide compound.

14. The method of claim 12 , wherein said superoxide dismutase mimic is a nitroxide compound selected from 2,2,6,6-tetramethylpiperidine-1-yloxy, 4-hydroxytetramethyl-piperidine-1-oxyl and 4-hydroxy-2,2,6,6,-tetramethylpiperidine-1-N-oxyl.

15. The method of claim 12 , wherein said superoxide dismutase mimic is a metal-chelate compound.

16. The method of claim 12 , wherein said superoxide dismutase mimic is selected from metal-pentaazacyclopentadecane compounds, metal-porphine compounds, metal-porphine compounds, metal-desferioxamine compounds, metal-bis(cyclohexylpyridine) compounds and salen-metal compounds.

17. The method of claim 12 , wherein said solution or dispersion is contacted with said medical device by spraying said medical device with said solution or dispersion.

18. The method of claim 12 , wherein said solution or dispersion is contacted with said medical device by dipping said medical device in said solution or dispersion.