Solubilized CoQ-10
The present invention is directed to compositions and methods of delivery of CoQ-10 solubilized in monoterpenes. Use of monoterpenes as dissolving agents, greatly effects the ability to incorporate greater amounts of bioactive CoQ-10 in formulations, such as soft gel capsules.
1. A solubilized coenzyme Q-10 composition comprising:
coenzyme Q-10;
a sufficient quantity of a limonene or a derivative suitable to solubilize said coenzyme Q-10 thereby providing a solution in which the coenzyme Q-10 remains solubilized, with the proviso that said solution is not part of an emulsion, suspension, or elixir.
2. The composition of claim 1 , wherein said coenzyme Q-10 is selected from the group consisting of oxidized coenzyme Q-10, reduced coenzyme Q-10 and semi-reduced coenzyme Q-10.
3. The composition of claim 1 , wherein said limonene derivatives are selected from the group consisting of perillyl alcohol, perillic acid, cis-dihydroperillic acid, trans-dihydroperillic acid, methyl esters of perillic acid, methyl esters of dihydroperillic acid, limonene-2-diol, uroterpenol, and combinations thereof.
4. The composition of claim 1 , further comprising a tocopherol.
5. The composition of claim 1 , wherein the limonene or a derivative thereof is limonene.
6. The composition of claim 2 , wherein the amount of coenzyme Q-10 said solution is about 15 percent up to about 60 percent by weight.
7. The composition of claim 2 , wherein the amount of coenzyme Q-10 in said solution is about 15 percent up to about 40 percent by weight.
8. The composition of claim 2 , wherein the amount of coenzyme Q-10 in said solution is about 20 percent up to about 40 percent by weight.
9. The composition of claim 2 , wherein the amount of coenzyme Q-10 in said solution is about 15 percent up to about 50 percent by weight.
10. The composition of claim 2 , wherein the amount of coenzyme Q-10 in said solution is about 20 percent up to about 60 percent by weight.
11. The composition of claim 2 , wherein the limonene or a derivative thereof is limonene.
12. A packaged nutraceutical formulation comprising:
coenzyme Q-10 and a sufficient quantity of a limonene or a derivative thereof suitable to solubilize said coenzyme Q-10 and form a solution with the proviso that said solution is not part of an emulsion, suspension, or elixir;
a tocopherol;
a carrier selected from the group consisting of rice bran oil and soybean oil, wherein said coenzyme Q-10 remains solubilized in the limonene or derivative thereof, tocopherol and carrier; and
instructions for use of the formulation.
13. The packaged nutraceutical formulation of claim 12 , wherein said coenzyme Q-10 is selected from the group consisting of oxidized coenzyme Q-10, reduced coenzyme Q-10 and semi-reduced coenzyme Q-10.
14. The packaged nutraceutical formulation of claim 12 , wherein said limonene derivatives are selected from the group consisting of perillyl alcohol, perillic acid, cis-dihydroperillic acid, trans-dihdroperillic acid, methyl esters of perillic acid, methyl esters of dihydroperillic acid, limonene-2-diol, uroterpenol, and combinations thereof.
15. The composition of claim 11 , wherein the said coenzyme Q-10 is oxidized coenzyme Q-10.
16. The composition of claim 11 , wherein the said coenzyme Q-10 is reduced coenzyme Q-10.
17. The composition of claim 11 , wherein the said coenzyme Q-10 is semi-reduced coenzyme Q-10.