IP Library Granted Patent US 7,341,369
Granted Patent B2
US 7,341,369 · App. 10/956,651 · Granted Mar 11, 2008

Isotropic illumination

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Quick Facts
Patent No.
US 7,341,369
App. No.
10/956,651
Granted
Mar 11, 2008
Kind
B2
Abstract

An isotropic illuminator is described, including a relay lens configured to focus a source image propagated from a source and a lightpipe having an entrance aperture and an exit aperture. The source image is aligned by a folding element to fill the entrance aperture and the lightpipe propagating the source image provides substantially uniform illumination from the exit aperture to a field stop. Focusing a source image propagated from a source, aligning the source image to fill an entrance aperture, and propagating the source image to provide substantially uniform illumination from an exit aperture to a field stop is also described. A specimen review system including a specimen stage configured to receive specimens for viewing, a source of illumination providing illumination to the specimen stage, and a review scope configured to review specimens on the specimen stage is also described.

Claims (55)

1. An isotropic illuminator, comprising:

a relay lens configured to focus a source image propagated from an incandescent light source; and

a lightpipe having an entrance aperture and an exit aperture, a diffuser located proximal to the entrance aperture of the lightpipe, the diffuser being connected to the lightpipe using a compressible ring and arranged perpendicular with respect to the lightpipe entrance aperture, wherein the source image is aligned by a first adjustable folding element to align the source image on a center of the diffuser, the lightpipe propagating the source image to provide substantially uniform illumination from the exit aperture to a field stop.

2. The isotropic illuminator of claim 1 , wherein the incandescent light source propagates the source image at a constant current.

3. The isotropic illuminator of claim 1 , further comprising a lens stop configured to receive spatially uniform illumination from the field stop.

4. The isotropic illuminator of claim 1 , further comprising a source stop.

5. The isotropic illuminator of claim 4 , wherein the source stop is configured to vary a brightness of the source image.

6. The isotropic illuminator of claim 4 , wherein a distance between the source image and the source stop is equal to approximately ten times a diameter of the source stop.

7. The isotropic illuminator of claim 1 , wherein an angular distribution of the source image is determined using a Fourier transformation.

8. The isotropic illuminator of claim 1 , wherein a length of the lightpipe is equal to at least ten times a diameter of the lightpipe.

9. The isotropic illuminator of claim 1 , wherein a field lens is located proximate the exit aperture.

10. The isotropic illuminator of claim 9 , wherein the field lens is connected to the lightpipe.

11. The isotropic illuminator of claim 9 , wherein the field lens is connected to the lightpipe using a compressible ring.

12. The isotropic illuminator of claim 9 , wherein the field lens has a focal length equal to approximately a distance between the field lens and a lens stop.

13. The isotropic illuminator of claim 1 , further comprising a field stop that is smaller than the exit aperture by at least one-tenth of a distance between the exit aperture and the field stop.

14. The isotropic illuminator of claim 1 , further comprising a first adjustable folding element between the relay lens and the source image, the first adjustable folding element is configured to align the source image in relation to a view screen.

15. The isotropic illuminator of claim 1 , further comprising:

a first adjustable folding element between the relay lens and the source image, the first adjustable folding element deflecting the source image towards the entrance aperture; and

a second adjustable folding element disposed between the first adjustable folding element and the entrance aperture, the second adjustable folding element aligning the source image on a view screen in a first position and aligning the source image in relation to the entrance aperture in a second position.

16. The isotropic illuminator of claim 15 , wherein the second adjustable folding element has a freedom of rotation between the first position and the second position.

17. The isotropic illuminator of claim 15 , wherein the second adjustable folding element has a freedom of translation between the first position and the second position.

18. The isotropic illuminator of claim 15 , further comprising a third adjustable folding element placed between the field stop and a lens stop, the third adjustable folding element aligning a field stop image on a specimen.

19. The isotropic illuminator of claim 15 , further comprising a condenser lens between the field stop and a lens stop.

20. The isotropic illuminator of claim 15 , wherein the uniform illumination is uniform in both angular and spatial orientation.

21. A method for isotropic illumination, comprising: providing an incandescent illumination source for producing a source image;

aligning the source image on a diffuser using a relay lens;

providing a first adjustable folding element between the relay lens and the source image, the first adjustable folding element configured to align the source image in relation to a view screen; and

propagating the source image through a lightpipe to provide substantially uniform illumination from an exit of the lightpipe aperture to a field stop, the diffuser arranged perpendicular with respect to an entrance of the lightpipe.

22. A biological specimen review system, comprising:

a specimen stage configured to receive biological specimens for viewing;

a source of incandescent illumination providing illumination to the specimen stage;

a review scope configured to review specimens on the specimen stage, the review scope including an isotropic illuminator configured to provide uniform angular illumination from the source to the specimen stage, the isotropic illuminator comprising:

a relay lens configured to focus a source image propagated from a source; and

a lightpipe having an entrance aperture and an exit aperture, a diffuser located proximal to the entrance aperture of the lightpipe, the diffuser being connected to the lightpipe using a compressible ring and arranged perpendicular to the entrance aperture, wherein the source image is aligned by a first adjustable folding element to align the source image on a center of the diffuser, the lightpipe propagating the source image to provide substantially uniform illumination from the exit aperture to a fieid stop.

23. A n isotropic illuminator, comprising:

a relay lens configured to focus a source image propagated from an incandescent light source; and

a lightpipe having an entrance aperture and an exit aperture, a diffuser located proximal to the entrance aperture of the lightpipe and arranged perpendicular with respect to the lightpipe entrance aperture, a field lens located proximate the exit aperture and connected to the lightpipe using a compressible ring, wherein the source image is aligned by a first adjustable folding element to align the source image on a center of the diffuser, the lightpipe propagating the source image to provide substantially uniform illumination from the exit aperture to a field stop.

24. The isotropic illuminator of claim 23 , wherein the incandescent light source propagates the source image at a constant current.

25. The isotropic illuminator of claim 23 , further comprising a lens stop configured to receive spatially uniform illumination from the field stop.

26. The isotropic illuminator of claim 23 , further comprising a source stop.

27. The isotropic illuminator of claim 26 , wherein the source stop is configured to vary a brightness of the source image.

28. The isotropic illuminator of claim 26 , wherein a distance between the source image and the source stop is equal to approximately ten times a diameter of the source stop.

29. The isotropic illuminator of claim 23 , wherein an angular distribution of the source image is determined using a Fourier transformation.

30. The isotropic illuminator of claim 23 , wherein a length of the lightpipe is equal to at least ten times a diameter of the lightpipe.

31. The isotropic illuminator of claim 23 , wherein the field lens has a focal length equal to approximately a distance between the field lens and a lens stop.

32. The isotropic illuminator of claim 23 , further comprising a field stop that is smaller than the exit aperture by at least one-tenth of a distance between the exit aperture and the field stop.

33. The isotropic illuminator of claim 23 , further comprising a first adjustable folding element between the relay lens and the source image, the first adjustable folding element is configured to align the source image in relation to a view screen.

34. The isotropic illuminator of claim 23 , further comprising:

a first adjustable folding element between the relay lens and the source image, the first adjustable folding element deflecting the source image towards the entrance aperture; and

a second adjustable folding element disposed between the first adjustable folding element and the entrance aperture, the second adjustable folding element aligning the source image on a view screen in a first position and aligning the source image in relation to the entrance aperture in a second position.

35. The isotropic illuminator of claim 34 , wherein the second adjustable folding element has a freedom of rotation between the first position and the second position.

36. The isotropic illuminator of claim 34 , wherein the second adjustable folding element has a freedom of translation between the first position and the second position.

37. The isotropic illuminator of claim 34 , further comprising a third adjustable folding element placed between the field stop and a lens stop, the third adjustable folding element aligning a field stop image on a specimen.

38. The isotropic illuminator of claim 34 , further comprising a condenser lens between the field stop and a lens stop.

39. The isotropic illuminator of claim 34 , wherein the uniform illumination is uniform in both angular and spatial orientation.

Assignments (10)
RELEASE OF SECURITY INTEREST Recorded Apr 28, 2026
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: HOLOGIC, INC., ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO DIRECT RADIOGRAPHY CORP.; CYTYC CORPORATION, ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO BIOLUCENT, LLC; CYTYC SURGICAL PRODUCTS, LLC, AS SUCCESSOR-BY-CONVERSION TO CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; GEN-PROBE INCORPORATED, ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.
Reel/Frame 075566/0039 →
CORRECTIVE ASSIGNMENT TO CORRECT THE INCORRECT PATENT NO. 8081301 PREVIOUSLY RECORDED AT REEL: 035820 FRAME: 0239. ASSIGNOR(S) HEREBY CONFIRMS THE SECURITY INTEREST RELEASE. Recorded Nov 9, 2017
From: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
To: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
Reel/Frame 044727/0529 →
CORRECTIVE ASSIGNMENT TO CORRECT THE INCORRECT PATENT NO. 8081301 PREVIOUSLY RECORDED AT REEL: 028810 FRAME: 0745. ASSIGNOR(S) HEREBY CONFIRMS THE SECURITY AGREEMENT. Recorded Nov 9, 2017
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
To: GOLDMAN SACHS BANK USA
Reel/Frame 044432/0565 →
SECURITY AGREEMENT Recorded Aug 7, 2015
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; DIRECT RADIOGRAPHY CORP.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 036307/0199 →
SECURITY INTEREST RELEASE REEL/FRAME 028810/0745 Recorded Jun 4, 2015
From: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
To: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
Reel/Frame 035820/0239 →
SECURITY AGREEMENT Recorded Aug 1, 2012
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
To: GOLDMAN SACHS BANK USA
Reel/Frame 028810/0745 →
TERMINATION OF PATENT SECURITY AGREEMENTS AND RELEASE OF SECURITY INTERESTS Recorded Aug 26, 2010
From: GOLDMAN SACHS CREDIT PARTNERS, L.P., AS COLLATERAL AGENT
To: HOLOGIC, INC.; R2 TECHNOLOGY, INC.; SUROS SURGICAL SYSTEMS, INC.; BIOLUCENT, LLC; DIRECT RADIOGRAPHY CORP.; CYTYC SURGICAL PRODUCTS II LIMITED PARTNERSHIP; CYTYC SURGICAL PRODUCTS LIMITED PARTNERSHIP; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS III, INC.; CYTYC PRENATAL PRODUCTS CORP.; THIRD WAVE TECHNOLOGIES, INC.
Reel/Frame 024892/0001 →
PATENT SECURITY AGREEMENT Recorded Jul 29, 2008
From: CYTYC CORPORATION
To: GOLDMAN SACHS CREDIT PARTNERS L.P., AS COLLATERAL AGENT
Reel/Frame 021301/0879 →
PATENT SECURITY AGREEMENT Recorded Oct 26, 2007
From: CYTYC CORPORATION
To: GOLDMAN SACHS CREDIT PARTNERS L.P.
Reel/Frame 020018/0529 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 7, 2004
From: SEWARD, GEORGE H.
To: CYTYC CORPORATION
Reel/Frame 015867/0321 →