Spirocyclic heterocyclic derivatives and methods of their use
View Patent ↗Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other δ opioid receptor-mediated conditions.
1. A compound which is 4-[(4-N,N-diethylaminocarbonyl)phenyl]-spiro[5-hydroxy-2H,1-benzopyran-2,4′-piperidine] or a pharmaceutically acceptable salt thereof.
2. A compound according to claim 1 which is in the form of a hydrochloride salt.
3. A pharmaceutical composition comprising the compound according to claim 1 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
4. A compound which is 4-[(4-N,N-diethylaminocarbonyl-2-hydroxy)phenyl]-spiro[2H,1-benzopyran-2,4′-piperidine] or a pharmaceutically acceptable salt thereof.
5. A pharmaceutical composition comprising the compound according to claim 4 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.