Method of forming a blister package including a fluoropolymer layer

1. A process for forming a pharmaceutical package comprising:

a) forming a multilayered film for holding a pharmaceutical product by:

i) forming a polymeric base layer;

ii) applying a fluoropolymer layer onto said polymeric base layer, which layers are attached via a first intermediate adhesive tie layer; and

iii) molding said film into a shaped blister container, which container has an outer surface, an inner surface, and a cavity;

b) placing a pharmaceutical product into said cavity; and

c) heat sealing a lid onto the outer surface of said container to close said product filled cavity, which lid comprises:

i) a support layer adhered to said fluoropolymer layer via a second intermediate adhesive tie layer; and

ii) a metallic foil layer adhered to said support layer.

2. The process of claim 1 wherein said pharmaceutical product comprises a tablet or a capsule.

3. The process of claim 1 wherein said base layer and said fluoropolymer layer are coextruded.

4. The process of claim 1 wherein said base layer and said fluoropolymer layer are laminated together.

5. The process of claim 1 wherein said molding comprises thermoforming.

6. The process of claim 1 further comprising adhering a paper to said foil layer via an intermediate adhesive layer.

7. The process of claim 1 wherein said fluoropolymer layer comprises a polychlorotrifluoroethylene homopolymer or copolymer.

8. The process of claim 1 wherein said the polymeric base layer comprises a material selected from the group consisting of polyamides, polyolefins, cyclic olefin copolymers, polyesters, poly(vinyl chloride), polyvinylidene chloride, polystyrene, acrylics and combinations thereof.

9. The process of claim 1 wherein said support layer comprises a material selected from the group consisting of polyolefins, polyamides, polyesters, polystyrene, poly(vinyl chloride), polyvinylidene chloride, polyurethanes and combinations thereof.

10. The process of claim 1 wherein said support layer comprises polyethylene terephthalate.

11. The process of claim 1 wherein said metaflic foil comprises an aluminum foil.

12. The process of claim 1 wherein said first intermediate adhesive tie layer comprises a material selected from the group consisting of a polyurethane, an epoxy, a polyester, an acrylic, an anhydride modified polyolefin and blends thereof.

13. The process of claim 1 wherein said second intermediate adhesive tie layer comprises a blend of (1) an olefin-containing polymer selected from the group consisting of at least one functionalized polyolefin; at least one copolymer of ethylene and at least one comonomer selected from the group consisting of acrylic acid, alkyl acrylic acid, acrylates, and alkyl acrylates; and blends thereof and (2) a styrene-ethylene-butylene-s-tyrene block copolymer.

14. A process for forming a package comprising:

a) forming a multilayered film for holding a product by:

i) forming a polymeric base layer;

ii) applying a fluoropolymer layer onto said polymeric base layer, which layers are attached via a first intermediate adhesive tie layer; and

iii) molding said film into a shaped container, which container has an outer surface, an inner surface, and a cavity;

b) placing a product into the cavity; and

c) heat sealing a lid onto the outer surface of the container to close the product filled cavity, which lid comprises:

i) a support layer adhered to said fluoropolymer layer via a second intermediate adhesive tie layer; and

ii) a metallic foil layer adhered to said support layer.