Enteric coated aspirin granules comingled with binder
View Patent ↗The invention relates to a tablet capable of being chewed or disintegrated in the oral cavity, which comprises an enteric coated granule comprising an intimate mixture of an aspirin active ingredient and at least one binder capable of preferentially absorbing ambient moisture.
1. A chewable tablet, comprising:
a mixture comprising:
aspirin, wherein said aspirin comprises about 13% by weight of a first coat comprising a mixture of about 66.7% of a cationic methacrylate polymer and about 33.3% talc and about 31.5% by weight of a second coat comprising about 87% polyvinylacetate phthalate and about 13% triacetin,
polyvinyl pyrrolidone;
dextrose monohydrate; and
saccharin;
wherein said tablet comprises a hardness of about 1 to about 8 kilopounds per square centimeter.
2. A tablet according to claim 1 wherein the dextrose monohydrate has an average granule size of about 100 microns to about 250 microns.
3. A tablet according to claim 1 , wherein the aspirin has an average granule size from about microns 100 to about 500 microns.
4. A tablet according to claim 1 , wherein said tablet has a hardness from about 2 to about 6 kilopounds per square centimeter.
5. A tablet according to claim 1 , wherein the dextrose monohydrate has an average granule size of about 100 microns to about 500 microns.
6. A tablet according to claim 1 , wherein the dextrose monohydrate has an average granule size of about 150 to about 200 microns.