Controlled muscle relaxation
In general, embodiments of the present invention provide a method of applying controlled neuromuscular block in a surgical patient until the end of the surgical procedure comprising the steps of (1) inducement of deep neuromuscular block by intravenous administration of an initial bolus dose of a neuromuscular blocking agent, (2) if needed, maintenance of deep neuromuscular block by intravenous application of maintenance doses of the blocking agent, and, in various embodiments, (3) reversal of the neuromuscular block by intravenous application of a bolus dose of a chemical chelator of the pertinent neuromuscular blocking agent.
1 . A method of applying controlled neuromuscular block in a surgical patient until the end of case comprising the steps of (1) inducement of deep neuromuscular block by intravenous administration of an initial bolus dose of a neuromuscular blocking agent, (2) if needed, maintenance of deep neuromuscular block by intravenous application of maintenance doses of the blocking agent, and (3) reversal of the neuromuscular block by intravenous application of a bolus dose of a chemical chelator of the pertinent neuromuscular blocking agent.
2 . The method of claim 1 , wherein the neuromuscular blocking agent is a steroidal neuromuscular blocking agent and the chemical chelator is a cyclodextrin derivative.
3 . The method of claim 2 , wherein the steroidal neuromuscular blocking agent is rocuronium bromide and the chemical chelator is of 6-per-deoxy-6-per-(2-carboxyethyl)thio-γ-cyclodextrin sodium salt (Org 25969).
4 . The method of claim 3 , comprising (1) inducement of deep neuromuscular block by intravenous administration of an initial bolus dose of 0.6-2.1 mg·kg −1 of rocuronium bromide, (2) if needed, maintenance of deep neuromuscular block by intravenous application of maintenance doses of 0.1-0.3 mg·kg −1 of rocuronium bromide administered at 10% recovery of control T1, and (3) reversal of the neuromuscular block by intravenous application of a bolus dose of 1.0-25 mg·kg −1 of 6-per-deoxy-6-per-(2-carboxyethyl)thio-γ-cyclodextrin sodium salt (Org 25969).
5 . The method according to claim 4 , wherein the initial bolus dose of rocuronium bromide is 0.6-1.2 mg·kg −1 .
6 . The method according to any one claims 3 - 5 , wherein the reversal of neuromuscular block is by intravenous application of a bolus dose of 4.0-12.0 m mg·kg −1 6-per-deoxy-6-per-(2-carboxyethyl)thio-γ-cyclodextrin sodium salt (Org 25969)
7 . The method of applying neuromuscular block in an emergency patient in need of rapid tracheal intubation, comprising (1) inducement of deep neuromuscular block by intravenous administration of a bolus dose of 0.6-2.1 mg·kg −1 of rocuronium bromide, and wherein either in case of a failed intubation or at the end of the emergency procedure the neuromuscular block is reversed by intravenous application of a bolus dose of 1.0-25 mg·kg −1 of 6-per-deoxy-6-per-(2-carboxyethyl)thio-γ-cyclodextrin sodium salt (Org 25969).