Aminocarboxylate ligands having substituted aromatic amide moieties
View Patent ↗Novel metal-chelate complexes comprising aminocarboxylate ligands including substituted aromatic amide moieties, such as those having the formula wherein R 13 , A 1 , R 1 and R 2 are as defined herein, are disclosed.
1. A compound of the formula
wherein
A 1 is —(CH 2 ) m ′ or a single bond;
(CH 2 ) m and (CH 2 ) m ′ may independently be substituted with alkyl or hydroxyalkyl;
R 1 and R 2 are each independently hydrogen or
with the proviso that at least one of R 1 and R 2 must be other than hydrogen;
R 3 and R 4 are independently hydrogen, alkyl, arylalkyl, aryl, alkoxy and hydroxyalkyl;
R 12 is hydrogen, alkyl or hydroxyalkyl;
R 13 is hydrogen, alkyl, arylalkyl, aryl, alkoxy or hydroxyalkyl;
m and m′ are independently 1 to 5; and multimeric forms thereof.
2. The compound of claim 1 having the name 10-[2-[[3,5-Bis-[[(2-hydroxy-1-(hydroxymethyl)ethyl]amino]carbonyl]phenylamino]2-oxoethyl]1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid.
3. The gadolinium complex of the compound of claim 2 .
4. The compound of claim 1 having the name 10-[2-[[3,5-Bis[[(2-methylbutyl)amino]carbonyl]-phenyl]amino]2-oxoethyl]1,4,7,10-tetraazacyclo-dodecane-1,4,7-triacetic acid.
5. The gadolinium complex of the compound of claim 4 .