GH secretagogues and uses thereof
View Patent ↗The invention relates to use of a GH secretagogue (e.g. GRF or an analog thereof) for (1) altering a lipid parameter in a subject; (2) altering a body composition parameter in a subject, (3) treating a condition characterized by deficient or decreased bone formation in a subject (4) improving daytime vigilance and/or cognitive function in a subject, (5) improving a metabolic condition in a subject, (6) improving anabolism in a catabolic condition in a subject, and/or (7) improving and/or reconstituting immune function in a subject.
1. A method of treating HIV-related lipodystrophy in a subject, said method comprising administering to said subject (hexenoyl trans-3)hGRF(1-44)NH 2 (SEQ ID NO: 7), to treat said HIV-related lipodystrophy.
2. The method of claim 1 , wherein said treating HIV-related lipodystrophy comprises treating visceral fat accumulation.
3. The method of claim 1 , wherein said subject is receiving antiviral therapy.
4. The method of claim 1 , wherein said (hexenoyl trans-3)hGRF(1-44)NH 2 (SEQ ID NO: 7) is administered at a dose selected from the group consisting of about 1 mg and about 2 mg.
5. The method of claim 1 , wherein said (hexenoyl trans-3)hGRF(1-44)NH 2 (SEQ ID NO: 7) is administered by a route selected from the group consisting of intravenous, oral, transdermal, subcutaneous, mucosal, intramuscular, intranasal, intrapulmonary, parenteral, intrarectal and topical.
6. The method of claim 5 , wherein said (hexenoyl trans-3)hGRF(1-44)NH 2 (SEQ ID NO: 7) agent is administered by a subcutaneous route.
7. The method of claim 4 , wherein said (hexenoyl trans-3)hGRF(1-44)NH 2 (SEQ ID NO: 7) is administered at a dose of about 2 mg.
8. The method of claim 6 , wherein said (hexenoyl trans-3)hGRF(1 -44)NH 2 (SEQ ID NO: 7) is administered at a dose of about 2 mg.