6-Methoxy-2-naphthylacetic acid prodrugs
The present invention provides therapeutically effective amounts of 6 MNA prodrugs. The pharmaceutical composition comprises wherein R is H or COR′, wherein R′ is selected from the group consisting of C 1 to C 6 alkyl, (CH 2 ) m O(CH 2 ) n , (CH 2 ) m (OC 2 H 4 ) p O(CH 2 ) n , (CH 2 ) m (OC 2 H 4 ) p , (OCH 2 H 4 ) p ONO 2 and (OCH 2 H 4 ) p O(CH 2 ) n wherein m is an integer from 2 to 4, and n and p are integers from 1 to 4. Alternatively, R is a therapeutic moiety.
1 . A pharmaceutical composition useful for treatment of inflammation to humans comprising a therapeutically effective amount of a compound of the formula:
wherein R is a therapeutic moiety.
2 . A method of treating inflammation comprising administering a therapeutically effective amount of a compound of the formula:
wherein R is a therapeutic moiety.