Nucleic acids encoding OBG3 globular head and uses thereof
View Patent ↗The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. A compound, globular OBG3, has been identified that reduces weight gain in animals. This compound should be effective for reducing body mass and for treating obesity-related diseases and disorders. These obesity-related diseases and disorders include hyperlipidemias, atherosclerosis, diabetes, and hypertension.
1. An isolated polynucleotide, or complement thereof, consisting of a nucleic acid sequence encoding consecutive amino acids 84 to 244, 85 to 244, 110 to 244, 102 to 244, or 103 to 244 of SEQ ID NO: 6.
2. The isolated polynucleotide according to claim 1 , wherein said nucleic acid sequence encodes consecutive amino acids 84 to 244 of SEQ ID NO: 6.
3. The isolated polynucleotide according to claim 1 , wherein said nucleic acid sequence encodes consecutive amino acids 85 to 244 of SEQ ID NO: 6.
4. The isolated polynucleotide according to claim 1 , wherein said nucleic acid sequence encodes consecutive amino acids 110 to 244 of SEQ ID NO: 6.
5. The isolated polynucleotide according to claim 1 , wherein said nucleic acid sequence encodes consecutive amino acids 102 to 244 of SEQ ID NO: 6.
6. The isolated polynucleotide according to claim 1 , wherein said nucleic acid sequence encodes consecutive amino acids 103 to 244 of SEQ ID NO: 6.
7. A composition comprising a carrier and an isolated polynucleotide, or complement thereof, consisting of a nucleic acid sequence encoding consecutive amino acids 84 to 244, 85 to 244, 110 to 244, 102 to 244, or 103 to 244 of SEQ ID NO: 6.
8. The composition according to claim 7 , wherein said nucleic acid sequence encodes consecutive amino acids 84 to 244 of SEQ ID NO: 6.
9. The composition according to claim 7 , wherein said nucleic acid sequence encodes consecutive amino acids 85 to 244 of SEQ ID NO: 6.
10. The composition according to claim 7 , wherein said nucleic acid sequence encodes consecutive amino acids 110 to 244 of SEQ ID NO: 6.
11. The composition according to claim 7 , wherein said nucleic acid sequence encodes consecutive amino acids 102 to 244 of SEQ ID NO: 6.
12. The composition according to claim 7 , wherein said nucleic acid sequence encodes consecutive amino acids 103 to 244 of SEQ ID NO: 6.
13. A vector comprising a polynucleotide, or complement thereof consisting of a nucleic acid sequence encoding consecutive amino acids 84 to 244, 85 to 244, 110 to 244, 102 to 244, or 103 to 244 of SEQ ID NO: 6.
14. The vector according to claim 7 , wherein said nucleic acid sequence encodes consecutive amino acids 84 to 244 of SEQ ID NO: 6.
15. The vector according to claim 7 , wherein said nucleic acid sequence encodes consecutive amino acids 85 to 244 of SEQ ID NO: 6.
16. The vector according to claim 7 , wherein said nucleic acid sequence encodes consecutive amino acids 110 to 244 of SEQ ID NO: 6.
17. The vector according to claim 7 , wherein said nucleic acid sequence encodes consecutive amino acids 102 to 244 of SEQ ID NO: 6.
18. The vector according to claim 7 , wherein said nucleic acid sequence encodes consecutive amino acids 103 to 244 of SEQ ID NO: 6.
19. A composition comprising a carrier and a vector comprising a polynucleotide, or complement thereof, consisting of a nucleic acid sequence encoding consecutive amino acids 84 to 244, 85 to 244, 110 to 244, 102 to 244, or 103 to 244 of SEQ ID NO: 6.
20. The composition according to claim 19 , wherein said nucleic acid sequence encodes consecutive amino acids 84 to 244 of SEQ ID NO: 6.
21. The composition according to claim 19 , wherein said nucleic acid sequence encodes consecutive amino acids 85 to 244 of SEQ ID NO: 6.
22. The composition according to claim 19 , wherein said nucleic acid sequence encodes consecutive amino acids 110 to 244 of SEQ ID NO: 6.
23. The composition according to claim 19 , wherein said nucleic acid sequence encodes consecutive amino acids 102 to 244 of SEQ ID NO: 6.
24. The composition according to claim 19 , wherein said nucleic acid sequence encodes consecutive amino acids 103 to 244 of SEQ ID NO: 6.
25. An isolated host cell comprising vector comprising an isolated polynucleotide, or complement thereof, consisting of a nucleic acid sequence encoding consecutive amino acids 84 to 244, 85 to 244, 110 to 244, 102 to 244, or 103 to 244 of SEQ ID NO: 6.
26. The isolated host cell according to claim 25 , wherein said nucleic acid sequence encodes consecutive amino acids 84 to 244 of SEQ ID NO: 6.
27. The isolated host cell according to claim 25 , wherein said nucleic acid sequence encodes consecutive amino acids 85 to 244 of SEQ ID NO: 6.
28. The isolated host cell according to claim 25 , wherein said nucleic acid sequence encodes consecutive amino acids 110 to 244 of SEQ ID NO: 6.
29. The isolated host cell according to claim 25 , wherein said nucleic acid sequence encodes consecutive amino acids 102 to 244 of SEQ ID NO: 6.
30. The isolated host cell according to claim 25 , wherein said nucleic acid sequence encodes consecutive amino acids 103 to 244 of SEQ ID NO: 6.