Reduced aperture biological specimen collection and transfer device
View Patent ↗A filtration based biological specimen collection and transfer device is provided. The filtration and transfer device comprises a tubular body with two axial ends, an annular flange disposed at one of the axial ends, and a biological specimen filter affixed to the outer surface of the annular flange. Preferably, the annular flange has disposed on its outer surface an annular ridge having a uniform height and forming a planar rim upon which the filter sits. Optionally, the annular flange comprises two mounting portions and the filter is bonded to each of those mounting portions. A method of collecting microscopic biological particles carried in a fluid is provided using the filtration and transfer device and a method of manufacturing the filtration and transfer device are also provided. A filtration based biological specimen collection and transfer system using the filtration and transfer device and a kit for use with filtration based biological specimen collection and transfer systems are also provided.
1. A biological specimen filter device, comprising:
a tubular body having first and second axially disposed ends and an interior region comprising a vacuum cavity, the first end comprising a planar annular mounting surface disposed substantially orthogonal to a longitudinal axis of the tubular body, the mounting surface having an annular ridge extending therefrom away from the tubular body and surrounding an aperture in a central region of the first end, the aperture in fluid communication with, and having a smaller diameter than, the vacuum cavity; and
a filter membrane having a peripheral region affixed to the mounting surface, and a central region that spans across the aperture, wherein a surface of the central region facing away from the tubular body is raised away from the peripheral region by the ridge and configured to contact a planar sample transfer surface without the transfer surface contacting the peripheral region of the filter.
2. The filter device of claim 1 , further comprising an annular air barrier interposed between the ridge and the mounting surface.
3. The filter device of claim 2 , the air barrier comprising a depression formed in the first end surrounding the ridge.
4. The filter device of claim 1 , wherein the filter membrane is configured for collecting thereon microscopic biological particles carried in a fluid.
5. A biological specimen filter device, comprising:
a tubular body having first and second axially disposed ends and an interior region comprising a vacuum cavity, the first end comprising a planar annular mounting surface disposed substantially orthogonal to a longitudinal axis of the tubular body, the mounting surface having an annular ridge extending therefrom away from the tubular body and surrounding an aperture in a central region of the first end, the aperture in fluid communication with, and having a smaller diameter than, the vacuum cavity, the first end further comprising a depression formed in the first end surrounding the ridge; and
a filter membrane configured for collecting thereon microscopic biological particles carried in a fluid and having a peripheral region affixed to the mounting surface, and a central region that spans across the aperture, wherein a surface of the central region facing away from the tubular body is raised away from the peripheral region by the ridge and configured to contact a planar sample transfer surface without the transfer surface contacting the peripheral region of the filter.
6. A biological specimen filter device, comprising:
a tubular body having first and second axially disposed ends and an interior region having a diameter defined by an inner wall of the tubular body, the first end comprising a planar annular mounting surface disposed substantially orthogonal to a longitudinal axis of the tubular body, the mounting surface having an annular ridge extending therefrom away from the tubular body and surrounding an aperture in a central region of the first end, the aperture in fluid communication with, and having a smaller than, the interior region of the tubular member; and
a filter membrane having a peripheral region affixed to the mounting surface, and a central region that spans across the aperture, wherein a surface of the central region facing away from the tubular body is raised away from the peripheral region by the ridge and configured to contact a planar sample transfer surface without the transfer surface contacting the peripheral region of the filter.
7. The filter device of claim 6 , further comprising an annular air barrier interposed between the ridge and the mounting surface.
8. The filter device of claim 7 , the air barrier comprising a depression formed in the first end surrounding the ridge.
9. The filter device of claim 6 , wherein the filter membrane is configured for collecting thereon microscopic biological particles carried in a fluid.