2-Phenylbenzofuran derivatives, a process for preparing them, and their use
View Patent ↗The present invention relates to 2-phenylbenzofurans of formula (I) which are formed, during fermentation, by the microorganism Aspergillus flavipes ST003878 (DSM 15290), to a process for preparing them and to their use as pharmaceuticals for the treatment and/or prophylaxis of bacterial infectious diseases or mycoses.
1. A compound of formula (I)
wherein
R 1 and R 2 are, independently of each other, H, OH or —O—(C 1 –C 6 )-alkyl, and
R 3 , R 4 , R 5 , R 6 and R 7 are, independently of each other, H, —(C 1 –C 6 )-alkyl or —C(O)—(C 1 –C 6 )-alkyl,
or a physiologically tolerated salt of a compound of formula (I).
2. A compound of formula (I) as claimed in claim 1 , wherein both R 1 and R 2 are H.
3. A compound of formula (I) as claimed in claim 1 , wherein R 3 , R 4 , R 5 , R 6 and R 7 are, independently of each other, H or methyl.
4. A compound of formula (I) as claimed in claim 1 , which is the compound of formula (II):
5. A compound of formula (I) as claimed in claim 1 , which has the formula (III):
6. A compound of formula (I) as claimed in claim 1 , which is the compound of formula (IV):
7. A compound of formula (I) as claimed in claim 1 , which is characterized by formula (V):
8. A pharmaceutical composition comprising a compound of formula (I) as claimed in claim 1 , or of a physiologically tolerated salt thereof.
9. The pharmaceutical composition of claim 8 for the treatment and/or prophylaxis of bacterial infectious diseases and/or mycoses.
10. A process for producing a pharmaceutical as claimed in claim 9 , which comprises mixing at least one compound of formula (I) with one or more pharmacologically suitable auxiliary substances or carrier substances.