Bone restorative carrier mediums

1. A method for delivering therapeutic material comprising

providing a pliable bone restorative comprising a homogeneous composite of biocompatible, resorbable polymer and the oxidation-reduction reaction product of at least one metal cation, at least one oxidizing agent, and at least one oxidizable precursor anion, said composite having macro-, meso-, and microporosity;

imbibing said bone restorative with a therapeutic material; and

placing said bone restorative into a bony space.

2. The method of claim 1 wherein said therapeutic material comprises at least one of blood, cells, protein rich plasma, growth hormone, antibiotic, cell signaling material, anti-bone resorption drug, chemotherapeutic agent, chemicals, DNA, RNA, fibrin sealant, liquid hemostat, vector, vitamin D, and sodium fluoride.

3. The method of claim 2 wherein said cells comprise fibroblasts, mesenchymal cells, stromal cells, marrow cells, adipocytes, myoblasts, or stem cells.

4. The method of claim 1 wherein said polymer is collagen.

5. The method of claim 1 wherein said reaction product is calcium phosphate.

6. The method of claim 1 wherein said reaction product is β-tricalcium phosphate.

7. The method of claim 1 wherein said bone restorative comprises wells or channels.

8. The method of claim 7 wherein said wells or channels contain therapeutic material or admixtures of autogenous bone chips and synthetic bone grafts.

9. The method of claim 1 wherein the therapeutic material is released over time.

10. The method of claim 1 wherein said therapeutic material comprises bone marrow aspirate.

11. A method for delivering therapeutic material comprising

providing a bone restorative comprising a homogeneous composite of biocompatible, resorbable collagen, the oxidation-reduction reaction product of at least one metal cation, at least one oxidizing agent, and at least one oxidizable precursor anion, said composite having macro-, meso-, and microporosity;

imbibing said bone restorative with a therapeutic material; and

placing said bone restorative into a bony space.

12. The method of claim 11 wherein said therapeutic material comprises at least one of blood, cells, protein rich plasma, growth hormone, antibiotic, cell signaling material, anti-bone resorption drug, chemotherapeutic agent, chemical, DNA, RNA, fibrin sealant, liquid hemostat, vector, vitamin D, and sodium fluoride.

13. The method of claim 11 wherein said cells comprise fibroblasts, mesenchymal cells, stromal cells, marrow cells, adipocytes, myoblasts, or stem cells.

14. The method of claim 11 wherein said reaction product is calcium phosphate.

15. The method of claim 11 wherein said reaction product is β-tricalcium phosphate.

16. The method of claim 11 wherein said bone restorative comprises wells or channels.

17. The method of claim 16 wherein said wells or channels contain therapeutic material or admixtures of autogenous bone chips and synthetic bone grafts.

18. The method of claim 11 wherein the therapeutic material is released over time.

19. The method of claim 11 wherein said therapeutic material comprises bone marrow aspirate.

20. A method for delivering therapeutic material comprising

providing a pliable bone restorative comprising a homogeneous composite of biocompatible, resorbable collagen and calcium phosphate, said composite having macro-, meso-, and microporosity;

imbibing said bone restorative with said therapeutic material; and

placing said bone restorative into a bony space.

21. The method of claim 20 wherein said therapeutic material comprises at least one of blood, cells, protein rich plasma, growth hormone, antibiotic, cell signaling material, anti-bone resorption drug, chemotherapeutic agent, chemical, RNA, DNA, fibrin sealant, liquid hemostat, vector, vitamin D, and sodium fluoride.

22. The method of claim 20 wherein said cells comprise fibroblasts, mesenchymal cells, stromal cells, marrow cells, adipocytes, myoblasts, or stem cells.

23. The method of claim 20 wherein said calcium phosphate is β-tricalcium phosphate.

24. The method of claim 20 wherein said bone restorative comprises wells or channels.

25. The method of claim 24 wherein said wells or channels contain therapeutic material or admixtures of autogenous bone chips and synthetic bone grafts.

26. The method of claim 20 wherein the therapeutic material is released over time.

27. The method of claim 20 wherein said therapeutic material comprises bone marrow aspirate.

28. A method for delivering therapeutic material comprising

providing a pliable bone restorative comprising a homogeneous composite of biocompatible, resorbable collagen and calcium phosphate having macro-, meso-, and microporosity;

imbibing said bone restorative with a therapeutic fluid; and

placing said bone restorative into a bony space.

29. The method of claim 28 wherein said therapeutic material comprises at least one of blood, cells, protein rich plasma, growth hormone, antibiotic, cell signaling material, anti-bone resorption drug, chemotherapeutic agent, chemical, DNA, RNA, fibrin sealant, liquid hemostat, vector, vitamin D, and sodium fluoride.

30. The method of claim 28 wherein said cells comprise fibroblasts, mesenchymal cells, stromal cells, marrow cells, adipocytes, myoblasts, or stem cells.

31. The method of claim 28 wherein said calcium phosphate is β-tricalcium phosphate.

32. The method of claim 28 wherein said bone restorative comprises wells or channels.

33. The method of claim 32 wherein said wells or channels contain therapeutic material or admixtures of autogenous bone chips and synthetic bone grafts.

34. The method of claim 28 wherein the therapeutic material is released over time.

35. The method of claim 28 wherein said therapeutic material comprises bone marrow aspirate.

36. A method for delivering therapeutic material comprising

providing a ductile bone restorative comprising a biocompatible mesh and a bone graft material comprising a homogeneous composite of biocompatible, resorbable collagen and calcium phosphate, said composite having macro-, meso-, and microporosity, and wells for containing therapeutic materials;

imbibing said bone restorative with a therapeutic fluid; and

placing said bone restorative into a bony space.

37. The method of claim 36 wherein said therapeutic material comprises at least one of blood, cells, protein rich plasma, growth hormone, antibiotic, cell signaling material, anti-bone resorption drug, chemotherapeutic agent, chemical, DNA, RNA, fibrin sealant, liquid hemostat, vector, vitamin D, and sodium fluoride.

38. The method of claim 36 wherein said cells comprise fibroblasts, mesenchymal cells, stromal cells, marrow cells, adipocytes, myoblasts, or stem cells.

39. The method of claim 36 wherein said calcium phosphate is β-tricalcium phosphate.

40. The method of claim 36 wherein said bone restorative further comprises channels.

41. The method of claim 40 , wherein said channels contain therapeutic material or admixtures of autologous bone chips and synthetic bone grafts.

42. The method of claim 36 wherein the therapeutic material is released over time.

43. The method of claim 36 wherein said therapeutic material comprises bone marrow aspirate.

44. A method for delivering therapeutic material comprising

providing a homogeneous composite of biocompatible, resorbable polymer, and the oxidation-reduction reaction product of at least one metal cation, at least one oxidizing agent, and at least one oxidizable precursor anion, said composite having macro-, meso-, and microporosity;

imbibing said composite with a therapeutic material, wherein said imbibing increases the mass of said composite by at least about 100%; and

placing said composite into a bony space.