Substantially monodispersed mixtures of polymers having polyethylene glycol moieties
View Patent ↗Methods of synthesizing a substantially monodispersed mixture of polymers comprising polyethylene glycol moieties include: reacting a substantially monodispersed mixture of compounds having the structure of Formula I: R 1 (OC 2 H 4 ) n —O − X + (I) wherein R 1 is H or a lipophilic moiety; n is from 1 to 25; and X + is a positive ion, with a substantially monodispersed mixture of compounds having the structure of Formula II: R 2 (OC 2 H 4 ) m —OMs (II) wherein R 2 is H or a lipophilic moiety; and m is from 1 to 25, under conditions sufficient to provide a substantially monodispersed mixture of polymers comprising polyethylene glycol moieties and having the structure of Formula III: R 2 (OC 2 H 4 ) m+n —OR 1 . (III) Substantially monodispersed mixtures of polymers comprising polyethylene glycol moieties are also disclosed.
1. A substantially monodispersed mixture of polymers, wherein at least 95 percent of the polymers in the mixture each has a formula:
R 2 (OC 2 H 4 ) n OR 1 (Formula A)
where
n is from 7 to 50,
R 1 is H or a lipophilic moiety, and
R 2 is H or a lipophilic moiety, and
wherein the at least 95 percent of the polymers in the mixture each has the same number of polyethylene glycol subunits.
2. The mixture of polymers of claim 1 wherein R 1 is H.
3. The mixture of polymers of claim 1 wherein R 2 is H.
4. The mixture of polymers of claim 1 wherein R 1 and R 2 are each H.
5. The mixture of polymers of claim 1 wherein R 1 is a lipophilic moiety.
6. The mixture of polymers of claim 1 wherein R 2 is a lipophilic moiety.
7. The mixture of polymers of claim 1 wherein R 1 and R 2 are each a lipophilic moiety.
8. The mixture of polymers of claim 1 wherein R 1 is alkyl.
9. The mixture of polymers of claim 1 wherein R 2 is alkyl.
10. The mixture of polymers of claim 1 wherein R 1 and R 2 are each alkyl.
11. The mixture of polymers of claim 1 wherein R 1 is fatty acid.
12. The mixture of polymers of claim 1 wherein R 2 is fatty acid.
13. The mixture of polymers of claim 1 wherein R 1 and R 2 are each fatty acid.
14. The mixture of polymers of claim 1 wherein R 1 is methyl.
15. The mixture of polymers of claim 1 wherein R 2 is methyl.
16. The mixture of polymers of claim 1 wherein R 1 and R 2 are each methyl.
17. The mixture of polymers of claim 1 , wherein at least 96 percent of the polymers in the mixture have the same molecular weight, wherein the at least 96 percent of the polymers in the mixture each has a Formula A, and wherein the at least 96 percent of the polymers in the mixture each has the same number of polyethylene glycol subunits.
18. The mixture of polymers of claim 1 , wherein at least 97 percent of the polymers in the mixture have the same molecular weight, wherein the at least 97 percent of the polymers in the mixture each has a Formula A, and wherein the at least 97 percent of the polymers in the mixture each has the same number of polyethylene glycol subunits.
19. The mixture of polymers of claim 1 , wherein at least 98 percent of the polymers in the mixture have the same molecular weight, wherein the at least 98 percent of the polymers in the mixture each has a Formula A, and wherein the at least 98 percent of the polymers in the mixture each has the same number of polyethylene glycol subunits.
20. The mixture of polymers of claim 1 , wherein at least 99 percent of the polymers in the mixture have the same molecular weight, wherein the at least 99 percent of the polymers in the mixture each has a Formula A, and wherein the at least 99 percent of the polymers in the mixture each has the same number of polyethylene glycol subunits.