IP Library › Granted Patent US 7,361,690
Granted Patent B2
US 7,361,690 · App. 10/978,565 · Granted Apr 22, 2008

Compositions and methods for the treatment of urinary incontinence

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Quick Facts
Patent No.
US 7,361,690
App. No.
10/978,565
Granted
Apr 22, 2008
Kind
B2
Abstract

A method for treating increased uninary urgency or urinary incontinence, comprising administering an effective amount of a compound corresponding to formula I It has been surprisingly discovered that the methods of the present invention are effective for treating increased urinary urgency or urinary incontinence. Also disclosed are methods of treatment using related pharmaceutical compositions.

Claims (15)

1. A method for treating increased urinary urgency or urinary incontinence, comprising administering to a subject in need thereof an effective amount of a compound selected from the group consisting of:

(1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol,

(+)-(1R,3R,6R)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol,

(1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-hydroxyphenyl)-cyclohexane-1,3-diol,

(1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol,

(+)-(1R,3R,5S)-3-(2-dimethylaminomethyl-1-hydroxy-5-methylcyclohexyl)-phenol, and

(1RS,2RS,5RS)-3-(2-dimethylaminomethyl-1 -hydroxy-5-trifluoromethylcyclohexyl)-phenol

or a salt thereof with a physiologically compatible acid.

2. A method according to claim 1 , wherein said compound is provided in a pharmaceutical composition with a pharmaceutically acceptable excipient.

3. A method according to claim 1 , wherein said compound is (1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol or a hydrochloride thereof.

4. A method according to claim 1 , wherein said compound is (+)-(1R,3R,6R)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol or a hydrochloride thereof.

5. A method according to claim 1 , wherein said compound is (1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-hydroxyphenyl)-cyclohexane-1,3-diol or a hydrochloride thereof.

6. A method according to claim 1 , wherein said compound is (1RS,3SR,6RS)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol or a hydrochloride thereof.

7. A method according to claim 1 , wherein said compound is (+)-(1R,3R,5S)-3-(2-dimethylaminomethyl-1-hydroxy-5-methylcyclohexyl)-phenol or a hydrochloride thereof.

8. A method according to claim 1 , wherein said compound is (1RS,2RS,5RS)-3-(2-dimethylaminomethyl-1 -hydroxy-5-trifluoromethylcyclohexyl)-phenol or a hydrochloride thereof.

Assignments (10)
RELEASE OF SECURITY INTEREST Recorded Apr 28, 2017
From: DEUTSCHE BANK AG NEW YORK BRANCH
To: ENDO PHARMACEUTICALS, INC.; ENDO PHARMACEUTICALS SOLUTIONS, INC.; ASTORA WOMEN'S HEALTH HOLDINGS, LLC
Reel/Frame 042362/0001 →
CORRECTIVE ASSIGNMENT TO CORRECT THE NAME OF RECEIVING PARTY IN RELEASE OF PATENT SECURITY INTEREST IN EXCLUSIVELY LICENSED PATENTS PREVIOUSLY RECORDED ON REEL 032380 FRAME 0157. ASSIGNOR(S) HEREBY CONFIRMS THE RELEASE OF SECURITY INTEREST IN EXCLUSIVELY LICENSED PATENTS.. Recorded Mar 24, 2014
From: MORGAN STANLEY SENIOR FUNDING, INC., AS ADMINISTRATIVE AGENT
To: ENDO PHARMACEUTICALS INC.
Reel/Frame 032513/0255 →
GRANT OF SECURITY INTEREST IN LICENSED PATENTS Recorded Mar 20, 2014
From: ENDO PHARMACEUTICALS, INC.
To: DEUTSCHE BANK AG NEW YORK BRANCH, AS COLLATERAL AGENT
Reel/Frame 032491/0620 →
RELEASE OF PATENT SECURITY INTEREST IN EXCLUSIVELY LICENSED PATENTS Recorded Mar 3, 2014
From: MORGAN STANLEY SENIOR FUNDING, INC., AS ADMINISTRATIVE AGENT
To: ENDO PHARMACEUTICALS SOLUTIONS INC.
Reel/Frame 032380/0157 →
RELEASE OF SECURITY INTEREST IN EXCLUSIVELY LICENSED PATENTS RECORDED AT REEL/FRAME 25456/172 Recorded Jul 12, 2011
From: JPMORGAN CHASE BANK N.A., AS ADMINISTRATIVE AGENT
To: ENDO PHARMACEUTICALS INC.
Reel/Frame 026577/0357 →
SECURITY INTEREST IN EXCLUSIVELY LICENSED PATENTS Recorded Jul 8, 2011
From: ENDO PHARMACEUTICALS INC.
To: MORGAN STANLEY SENIOR FUNDING, INC., AS ADMINISTRATIVE AGENT
Reel/Frame 026561/0978 →
CONFIRMATORY GRANT OF SECURITY INTEREST IN UNITED STATES PATENTS (EXCLUSIVELY LICENSED PATENTS) Recorded Dec 9, 2010
From: ENDO PHARMACEUTICALS INC.
To: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 025456/0172 →
RELEASE OF SECURITY INTEREST RECORDED AT REEL/FRAME 23928/628 Recorded Dec 9, 2010
From: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
To: ENDO PHARMACEUTICALS INC.
Reel/Frame 025456/0778 →
CONFIRMATORY GRANT OF SECURITY INTEREST IN UNITED STATES PATENTS (EXCLUSIVELY LICENSED PATENTS) Recorded Feb 13, 2010
From: ENDO PHARMACEUTICALS INC.
To: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 023928/0628 →
LICENSE Recorded Oct 30, 2009
From: GRUNENTHAL GMBH
To: ENDO PHARMACEUTICALS INC.
Reel/Frame 023449/0279 →