Methods for reducing cholesterol using
View Patent ↗The invention describes therapeutic compositions including a lactic acid-producing bacteria, such as isolated Bacillus coagulans , in combination with a bifidogenic oligosaccharides or other cholesterol-reducing agents for use in reducing LDL cholesterol and serum triglycerides. Also described are therapeutic methods using the compositions and systems containing the therapeutic compositions.
1. A method for decreasing serum cholesterol, decreasing serum triglycerides, and increasing serum HDL in a patient comprising administering to said patient an effective amount of a composition comprising viable Bacillus coagulans bacteria.
2. The method of claim 1 , wherein said Bacillus coagulans bacteria are Bacillus coagulans subspecies Hammer.
3. The method of claim 1 , wherein said Bacillus coagulans bacteria are Bacillus coagulans subspecies Hammer deposited under ATCC deposit number 31284.
4. The method of claim 1 , wherein said composition contains 2×10 5 to 1×10 10 viable bacteria per gram of composition.
5. The method of claim 1 , wherein said composition contains 1×10 7 to 1×10 10 viable bacteria per gram of composition.
6. The method of claim 1 , wherein said administering comprises introducing into the digestive tract from 10 8 to 10 10 viable bacteria per day.
7. The method of claim 1 , wherein said composition contains 5×10 8 to 1×10 9 viable bacteria per gram of composition.
8. The method of claim 1 wherein said administering comprises introducing into the digestive tract from 5×10 8 to 5×10 9 viable bacteria per day.
9. The method of claim 1 , wherein said administering comprises oral ingestion of said composition.
10. The method of claim 1 , wherein said administering comprises introducing into the digestive tract from 0.1 to 5 grams per day of said composition.
11. The method of claim 1 , wherein composition is in the form of a capsule, tablet, powder, semi-solid formulation, liquid, gel, suspension, or aerosol spray.
12. The method of claim 1 , wherein said composition further comprises a cholesterol-reducing agent.
13. The method of claim 1 , wherein said cholesterol-reducing agent is selected from the group consisting of a statin, a bile sequestering compound, a fiber product capable of binding cholesterol, niacin and aspirin.
14. The method of claim 13 , wherein said statin is selected from the group consisting of cerivastatin, fluvastatin, lovastatin, pravastatin and simvastatin.
15. The method of claim 14 , wherein said administering comprises introducing into the digestive tract from 10 to 80 milligrams of statin per day.
16. The method of claim 13 , wherein said bile sequestering compound is selected from the group consisting of colestipol and cholestyramine.
17. The method of claim 16 , wherein said administering comprises introducing into the digestive tract from 1 to 20 grams of bile sequestering compound per day.
18. The method of claim 16 , wherein said administering comprises introducing into the digestive tract from 6 to 8 grams of bile sequestering compound per day.
19. The method of claim 13 , wherein said fiber product is selected from the group consisting of gemfibrozil, fenofibrate, psyllium, bran, glucomannan and Jerusalem artichoke flour.
20. The method of claim 19 , wherein said administering comprises introducing into the digestive tract from 500 milligrams to 50 grams of fiber per day.
21. The method of claim 1 , wherein said composition further comprises a cholic acid complexation agent.
22. The method of claim 21 , wherein said complexation agent is a salt of a metal selected from the group consisting of calcium, chromium, copper, iodine, iron, magnesium, manganese, potassium sodium, and zinc.
23. The method of claim 22 , wherein said metal salt is provided in the form of calcium citrate, potassium gluconate, magnesium citrate or chromium picollinate.
24. The method of claim 1 , wherein said composition further comprises a food substance, flavoring, vitamin or mineral.
25. The method of claim 24 , wherein said vitamin is selected from the group consisting of choline, B-6, B-12, niacin, pantothenic acid, riboflavin, inositol, thiamine, and folic acid.
26. The method of claim 1 , wherein said patient is at risk for atherosclerosis, arterial sclerosis, myocardial infarction, heart attack, diabetes, coronary heart disease, angina pectoris or unstable angina.
27. A method for decreasing serum cholesterol, decreasing serum triglycerides, and increasing serum HDL in a patient comprising administering to the digestive tract of said patient an effective amount of a composition comprising viable Sporolactobacillus P44 bacteria.