Introducing aerosol into a ventilator
View Patent ↗An aerosol introducer is provided for introducing an aerosolized pharmaceutical formulation into a ventilator circuit. The ventilator circuit comprises an endotracheal tube, an inhalation line extending from a ventilator, and an exhalation line extending from the ventilator. The aerosol introducer comprises a first end connectable to the inhalation line and the exhalation line; a second end connectable to the endotracheal tube; a first channel extending from the first end to the second end; a second channel extending from the first end to the second end; an inlet in the first channel, the inlet being adapted to receive an aerosolized pharmaceutical formulation; and a valving mechanism comprising one or more valves that reduce the loss of aerosolized pharmaceutical formulation to the exhalation line.
1. An aerosol introducer for introducing an aerosolized pharmaceutical formulation into a ventilator circuit, the ventilator circuit comprising an endotracheal tube, an inhalation line extending from a ventilator for delivering inhalation flow from the ventilator, and an exhalation line extending from the ventilator for delivering exhalation flow to the ventilator, the aerosol introducer comprising:
a body comprising
a first channel,
a second channel,
a cross channel,
first and second connectors on one side of the body, the first connector being directly connectable to the inhalation line and the second connector being directly connectable to the exhalation line, and
first and second inlets on a side of the body opposite to the side with the first and second connectors, the first and second inlets being connectable to a Y-piece,
wherein the first channel extends from the first connector to the first inlet, wherein the second channel extends from the second connector to the second inlet, wherein the cross channel connects the first channel to the second channel at a position between the side with the connectors and the side with the inlets, and wherein the first connector and the second connector are separate connectors,
a nebulizer inlet coupled to the body, the nebulizer inlet being adapted to receive an aerosolized pharmaceutical formulation, and
a valving mechanism within the body comprising one or more valves, wherein at least one valve is a one-way valve such that, in use with the ventilation circuit, only inhalation flow may pass through the first channel.
2. An aerosol introducer according to claim 1 wherein the valving mechanism is adapted to reduce the loss of aerosolized pharmaceutical formulation to the exhalation line.
3. An aerosol introducer according to claim 1 wherein the valving mechanism comprises a one-way valve positioned within the first channel.
4. An aerosol introducer according to claim 3 wherein the valving mechanism comprises a one-way valve positioned within the second channel.
5. An aerosol introducer according to claim 1 wherein the valving mechanism comprises a one-way valve positioned within the second channel.
6. An aerosol introducer according to claim 1 in combination with the Y-piece, wherein the Y-piece is connectable to the endotracheal tube.
7. An aerosol introducer according to claim 1 further comprising a nebulizer associated with the nebulizer inlet.
8. An aerosol introducer according to claim 7 wherein the nebulizer comprises a vibrating mesh.
9. An aerosol introducer according to claim 1 wherein the nebulizer contains the pharmaceutical formulation and wherein the pharmaceutical formulation comprises amikacin.
10. An aerosol introducer according to claim 1 wherein the nebulizer contains the pharmaceutical formulation and wherein the pharmaceutical formulation comprises vancomycin.
11. An aerosol introducer according to claim 1 wherein the nebulizer contains the pharmaceutical formulation and wherein the pharmaceutical formulation comprises gentamycin.
12. An aerosol introducer according to claim 1 wherein the nebulizer contains the pharmaceutical formulation and wherein the pharmaceutical formulation comprises a fluoroquinolone.
13. An aerosol introducer according to claim 1 wherein the volume of the first channel is from about 10 mL to about 1000 mL.