Biguanide/quaternary ammonium containing copolymeric biocides and use thereof in pharmaceutical compositions
View Patent ↗Biguanide/quaternary ammonium compounds and the use of same as antimicrobial agents in pharmaceutical compositions are described. The biguanide/quaternary ammonium compounds are useful in the preservation of pharmaceutical compositions, particularly ophthalmic pharmaceutical compositions and compositions for treating contact lenses. The compounds are especially useful for disinfecting contact lenses.
1. A compound of the following formula:
wherein:
n is a whole number of from 1 to 100;
R 1 and R 2 are the same or different and are selected from the group consisting of alkyl (C 1 –C 10 ), aryl, and arylalkyl (C 3 –C 16 ), all of which may optionally contain one or more heteroatoms;
X is selected from the group consisting of alkyl (C 2 –C 16 ), aryl, and arylalkyl (C 3 –C 12 );
Y is selected from the group consisting of alkyl (C 2 –C 16 ), aryl, and arylalkyl (C 3 –C 12 ); and
Q is selected from the group consisting of alkyl (C 2 –C 20 ), aryl, arylalkyl (C 3 –C 20 ), amino alkyl (C 2 –C 20 ), alkenyl (C 2 –C 20 ), and alkylalkenyl (C 4 –C 20 ), all of which may optionally contain one or more quaternary ammonium moieties or heteroatoms; or a pharmaceutically acceptable salt thereof.
2. A compound according to claim 1 , wherein R 1 and R 2 are the same or different and are selected from the group consisting of alkyl (C 1 –C 6 ) and arylalkyl (C 3 –C 12 ); and Y is alkyl (C 2 –C 12 ).
3. A compound according to claim 2 , wherein n is 1 to 20; R 1 and R 2 are methyl; X is propyl; Y is hexyl; and Q is selected from the group consisting of trans-2-butene and bis-(N,N-dimethyl-N-trans-2-butenylamino)dodecane.
4. A pharmaceutical composition comprising an amount of a compound of claim 1 effective to preserve the composition from microbial contamination.
5. A pharmaceutical composition according to claim 4 , wherein the composition is an aqueous ophthalmic composition.
6. A pharmaceutical composition according to claim 4 , wherein the composition is an aqueous otic composition.
7. A pharmaceutical composition according to claim 4 , wherein the composition is utilized to treat contact lenses.
8. A composition for disinfecting contact lenses, comprising a disinfecting amount of a compound of claim 1 , and an ophthalmically acceptable vehicle therefor.
9. A method of disinfecting a contact lens, which comprises applying the composition of claim 8 to the lens.
10. A method of preserving pharmaceutical compositions from microbial contamination, which comprises including a preservative effective amount of a compound of claim 1 in the composition.