IP Library › Granted Patent US 7,432,290
Granted Patent B2
US 7,432,290 · App. 10/997,810 · Granted Oct 7, 2008

Inhibitors of IMPDH enzyme

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Quick Facts
Patent No.
US 7,432,290
App. No.
10/997,810
Granted
Oct 7, 2008
Kind
B2
Abstract

The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

Claims (2)

1. A compounds of formula 181:

2. A pharmaceutical composition comprising a compound according to claim 1 in an amount effective to inhibit IMPDH and a pharmaceutically acceptable carrier, adjuvant or vehicle.

Assignments (3)
RELEASE OF SECURITY INTEREST Recorded Oct 14, 2016
From: MACQUARIE US TRADING LLC
To: VERTEX PHARMACEUTICALS INCORPORATED; VERTEX PHARMACEUTICALS (SAN DIEGO) LLC
Reel/Frame 040357/0001 →
SECURITY INTEREST Recorded Jul 10, 2014
From: VERTEX PHARMACEUTICALS INCORPORATED; VERTEX PHARMACEUTICALS (SAN DIEGO) LLC
To: MACQUARIE US TRADING LLC
Reel/Frame 033292/0311 →
SECURITY AGREEMENT Recorded Oct 28, 2008
From: AVALON PHARMACEUTICALS, INC.
To: CLINICAL DATA, INC.
Reel/Frame 021744/0652 →