Method for treatment and repair of meniscal injuries
View Patent ↗A method for repair of meniscal injuries comprising induction of meniscal regeneration by introducing a strongly adhesive collagen-polyethylene glycol (PEG) hydrogel to a site of injury.
1. A method for repair of meniscal injury, lesion or tear by introducing into a site of the meniscus injury, lesion or tear an adhesive rapidly gelling biodegradable derivatized collagen-PEG hydrogel complex wherein said derivatized collagen is alkylated Type I collagen.
2. The method of claim 1 wherein said collagen-PEG hydrogel complex further comprises Type I collagen microfibrils.
3. The method of claim 1 wherein the collagen-PEG hydrogel complex is further complemented with a growth factor.
4. The method of claim 1 wherein said collagen-PEG hydrogel complex is introduced into a site of the injury, lesion or tear alone or incorporated into a support matrix.
5. The method of claim 4 wherein the support matrix is a Type I collagen, Type II collagen, Type IV collagen, gelatin, agarose, cell-contracted collagen containing proteoglycan, glycosaminoglycan, glycoprotein, fibronectin, laminin, bioactive peptide growth factor, cytokine, elastin, fibrin, synthetic polymeric fiber made of poly-acid, polycaprolactone, polyamino acid, polypeptide gel or a copolymer thereof or a combination thereof.
6. The method of claim 4 wherein the support matrix is a Type I or Type II collagen honeycomb, sponge or scaffold.
7. The method of claim 4 wherein the support matrix is the Type I collagen honeycomb.
8. The method of claim 6 wherein the support matrix is the Type I collagen scaffold.
9. The method of claim 6 wherein the support matrix is the Type I collagen sponge.
10. The method of claim 1 wherein the alkylated collagen is methylated collagen.
11. The method of claim 1 wherein the polyethylene glycol is derivatized or non-derivatized.
12. The method of claim 11 wherein the polyethylene glycol is non-derivatized.
13. The method of claim 11 wherein the polyethylene glycol is derivatized with succinimidyl ester, tetra-thiol, tetra-hydroxysuccinimidyl or albumin.
14. The method of claim 10 wherein the collagen-PEG hydrogel complex introduced into the site of the meniscus injury, lesion or tear further comprises autologous cells.
15. The method of claim 1 wherein said derivatized collagen-PEG hydrogel complex is introduced into the site of the meniscus injury, lesion or tear and the injury, lesion or tear is further treated with sutures.
16. The method of claim 1 wherein the said derivatized collagen-PEG hydrogel complex introduced into the site of the meniscus injury, lesion or tear further comprises a synovial tissue.
17. The method of claim 1 wherein said derivatized collagen-PEG hydrogel complex is incorporated into a support matrix and said matrix is introduced into the site of the meniscus injury, lesion or tear and said injury, lesion or tear is further treated with sutures.