Alkylpolypropyleneoxide amidotriamines and method of using same
View Patent ↗Alkylpolypropyleneoxide amidotriamines having antimicrobial activity are described. The compounds are useful as antimicrobial preservatives in various types of pharmaceutical compositions. Ophthalmic compositions containing these compounds as disinfecting agents or preservatives are also described.
1. A compound of the formula:
wherein:
R is C 6 to C 18 alkyl; and
n is 1 to 100; or a pharmaceutically acceptable salt thereof.
2. A compound according to claim 1 , wherein R is C 12 to C 16 alkyl and n is 6 to 12.
3. A pharmaceutical composition containing a compound of claim 1 in an amount effective to preserve the composition from microbial contamination.
4. A composition for disinfecting contact lenses, comprising a compound of claim 1 in an amount effective to disinfect contact lenses, and a pharmaceutically acceptable vehicle therefor.