IP Library › Granted Patent US 7,491,524
Granted Patent B2
US 7,491,524 · App. 11/001,993 · Granted Feb 17, 2009

Human RNase III and compositions and uses thereof

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Quick Facts
Patent No.
US 7,491,524
App. No.
11/001,993
Granted
Feb 17, 2009
Kind
B2
Abstract

The present invention provides polynucleotides encoding human RNase III and polypeptides encoded thereby. Methods of using said polynucleotides and polypeptides are also provided.

Claims (6)

1. A method of increasing cleavage of a target RNA in a mammalian cell comprising increasing the amount of a polypeptide in the cell, wherein the polypeptide comprises amino acids 906-1374 of the amino acid sequence recited as SEQ ID NO: 2 and wherein the RNA target comprises a double helical structure; and thereby increasing cleavage of the target RNA in the mammalian cell.

2. The method of claim 1 , wherein the increasing the amount of the polypeptide comprises overexpression of the polypeptide.

3. The method of claim 1 , wherein the polypeptide consists of the amino acid sequence recited as SEQ ID NO: 2.

4. The method of claim 1 , wherein the cell is a human cell.

5. The method of claim 4 , wherein the increasing the amount of the polypeptide comprises overexpression of the polypeptide.

6. The method of claim 4 , wherein the polypeptide consists of the amino acid sequence of SEQ ID NO: 2.

Assignments (2)
CHANGE OF NAME Recorded Jul 26, 2017
From: ISIS PHARMACEUTICALS, INC.
To: IONIS PHARMACEUTICALS, INC.
Reel/Frame 043341/0519 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 7, 2005
From: CROOKE, STANLEY T.
To: ISIS PHARMACEUTICALS, INC.
Reel/Frame 015850/0542 →