Imidazonaphthyridines

1. A compound of formula

wherein

A is —N═CR—CR═CR—; —CR═N—CR═CR—; —CR═CR—N═CR—; or —CR═CR—CR═N—;

R 1 is selected from the group consisting of:

-hydrogen;

—C 1-20 alkyl or C 2-20 alkenyl that is unsubstituted or substituted by one or more substituents selected from the group consisting of:

-aryl;

-heteroaryl;

-heterocyclyl;

—O—C 1-20 alkyl,

—O—(C 1-20 alkyl) 0-1 -aryl;

—O—(C 1-20 alkyl) 0-1 -heteroaryl;

—O—(C 1-20 alkyl) 0-1 -heterocyclyl;

—C 1-20 alkoxycarbonyl;

—S(O) 0-2 —C 1-20 alkyl;

—S(O) 0-2 —(C 1-20 alkyl) 0-1 -aryl;

—S(O) 0-2 —(C 1-20 alkyl) 0-1 -heteroaryl;

—S(O) 0-2 —(C 1-20 alkyl) 0-1 -heterocyclyl;

—N(R 3 ) 2 ;

—N 3 ;

oxo;

-halogen;

—NO 2 ;

—OH; and

—SH; and

—C 1-20 alkyl-NR 3 —Q—X—R 4 or —C 2-20 alkenyl-NR 3 —Q—X—R 4 wherein Q is —CO— or —SO 2 —; X is a bond, —O— or —NR 3 — and R 4 is aryl; heteroaryl; heterocyclyl; or —C 1-20 alkyl or C 2-20 alkenyl that is unsubstituted or substituted by one or more substituents selected from the group consisting of:

-aryl;

-heteroaryl;

-heterocyclyl;

—O—C 1-20 alkyl,

—O—(C 1-20 alkyl) 0-1 -aryl;

—O—(C 1-20 alkyl) 0-1 -heteroaryl;

—O—(C 1-20 alkyl) 0-1 -heterocyclyl;

—C 1-20 alkoxycarbonyl;

—S(O) 0-2 —C 1-20 alkyl;

—S(O) 0-2 —(C 1-20 alkyl) 0-1 -aryl;

—S(O) 0-2 —(C 1-20 alkyl) 0-1 -heteroaryl;

—S(O) 0-2 —(C 1-20 alkyl) 0-1 -heterocyclyl;

—N(R 3 ) 2 ;

—NR 3 —CO—O—C 1-20 alkyl;

—N 3 ;

oxo;

-halogen;

—NO 2 ;

—OH; and

—SH; or R 4 is

wherein Y is —N— or —CR—;

R 2 is selected from the group consisting of:

-hydrogen;

—C 1-10 alkyl;

—C 2-10 alkenyl;

-aryl

—C 1-10 alkyl —O—C 1-10 -alkyl;

—C 1-10 alkyl-O—C 2-10 alkenyl; and

—C 1-10 alkyl or C 2-10 alkenyl substituted by one or more substituents selected from the group consisting of:

—OH;

-halogen;

—N(R 3 ) 2 ;

—CO—N(R 3 ) 2 ;

—CO—C 1-10 alkyl;

—N 3 ;

-aryl;

-heteroaryl;

-heterocyclyl;

—CO-aryl; and

—CO-heteroaryl;

each R 3 is independently selected from the group consisting of hydrogen and C 1-10 alkyl; and

each R is independently selected from the group consisting of hydrogen, C 1-10 alkyl, C 1-10 alkoxy, halogen and trifluoromethyl,

or a pharmaceutically acceptable salt thereof.