IP Library › Granted Patent US 7,597,895
Granted Patent B2
US 7,597,895 · App. 11/005,636 · Granted Oct 6, 2009

Signal peptides, nucleic acid molecules and methods for treatment of caries

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Quick Facts
Patent No.
US 7,597,895
App. No.
11/005,636
Granted
Oct 6, 2009
Kind
B2
Abstract

Compounds that competitively inhibit binding of CSP to S. mutans histidine kinase are provided. The compounds are preferably a peptide or an antibody, and are preferably a derivative of [SEQ ID NO:2], a fragment of [SEQ ID NO:2] or a derivative of a fragment of [SEQ ID NO:2]. Methods of making these compounds and their use for inhibiting the growth of S. mutans , for inhibiting dental caries, and for improving dental health are also disclosed.

Claims (15)

1. A composition comprising a peptide analog of SEQ ID NO:11, wherein the peptide analog is SEQ ID NO:48.

2. The composition of claim 1 further comprising at least one other inhibitor of SEQ ID NO: 11.

3. The composition of claim 2 wherein the other inhibitor of SEQ ID NO: 11 is an antibody specific for SEQ ID NO: 11.

4. The composition of claim 3 wherein the antibody is a monoclonal antibody.

5. The composition of claim 2 wherein the other inhibitor of SEQ ID NO: 11 is SEQ ID NO: 41, SEQ ID NO: 42, SEQ ID NO: 43, SEQ ID NO: 49, SEQ ID NO: 50, SEQ ID NO: 51, or a combination thereof.

6. The composition of claim 1 further comprising an antibiotic.

7. The composition of claim 2 further comprising an antibiotic.

8. The composition of claim 1 further comprising an antioxidant.

9. The composition of claim 2 further comprising an antioxidant.

10. The composition of claim 1 , wherein the composition is toothpaste, mouthwash, food, food additive, dental floss, or chewing gum.

11. The composition of claim 2 , wherein the composition is toothpaste, mouthwash, food, food additive, dental floss, or chewing gum.

12. The composition of claim 1 , wherein SEQ ID NO:48 is coupled to a lipid, a carbohydrate, or a polymer.

13. The composition of claim 2 , wherein SEQ ID NO:48 is coupled to a lipid, a carbohydrate, or a polymer.

14. The composition of claim 5 , wherein SEQ ID NO: 41, SEQ ID NO: 42, SEQ ID NO: 43, SEQ ID NO: 49, SEQ ID NO: 50, SEQ ID NO: 51, or a combination thereof is coupled to a lipid, a carbohydrate, or a polymer.

15. A method of treating caries comprising administering a composition of claim 1 .

Assignments (2)
SECURITY INTEREST Recorded Nov 9, 2020
From: KANE BIOTECH INC.
To: PIVOT FINANCIAL INC.
Reel/Frame 054307/0264 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 9, 2006
From: CVITKOVITCH, DENNIS G.; LAU, PETER CHUN YU; LI, YUNG-HUA
To: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
Reel/Frame 018364/0481 →