Enone cancer therapeutics
View Patent ↗Described herein are new enone derivatives and conjugates. Additionally, methods for synthesizing these new enones are also disclosed. These compounds can be employed in cancer therapy.
1. A compound of Formula 7
wherein X is a nucleophilic atom selected from the group consisting of S, N, and O and R is selected from the group consisting of COCH 3 , COC 6 H 5 and CONHCH 3 ; stereoisomers and positional isomers thereof.
2. The compound of claim 1 , wherein said compound is bound to a water-soluble copolymer.
3. The compound of claim 2 , wherein said water-soluble copolymer comprises N-(2-hydroxypropyl)methacrylamide copolymer.
4. A compound of Formula 1 or 6
wherein X is a nucleophilic atom selected from the group consisting of S and N; and R is selected from the group consisting of COC 6 H 5 and CONHCH 3 ; stereoisomers and positional isomers thereof.
5. The compound of claim 4 , wherein said compound is bound to a water-soluble copolymer.
6. The compound of claim 5 , wherein said water-soluble copolymer comprises N-(2-hydroxypropyl)methacrylamide copolymer.
7. A compound of Formula 1 or 6
wherein X is a nucleophilic atom selected from the group consisting of S, N and O; and R is CONHCH 3 ; stereoisomers and positional isomers thereof.
8. The compound of claim 7 , wherein said compound is bound to a water-soluble copolymer.
9. The compound of claim 8 , wherein said water-soluble copolymer comprises N-(2-hydroxypropyl)methacrylamide copolymer.