IL-B30 antibodies
View Patent ↗Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
1. A recombinant antibody or antigen binding fragment thereof that binds to a polypeptide having the amino acid sequence of SEQ ID NO: 2.
2. The antigen binding fragment of claim 1 selected from:
a) a Fab fragment;
b) a Fab 2 fragment; or
c) a single chain antibody.
3. The recombinant antibody or antigen binding fragment of claim 1 , which binds said polypeptide with an affinity of at least 100 nM.
4. The recombinant antibody or antigen binding fragment of claim 1 , which binds said polypeptide with an affinity of at least 30 nM.
5. The recombinant antibody or antigen binding fragment of claim 1 , which binds said polypeptide with an affinity of at least 10 nM.
6. The recombinant antibody or antigen binding fragment of claim 1 , which binds said polypeptide with an affinity of at least 3 nM.
7. The recombinant antibody or antigen binding fragment of claim 1 , which binds said polypeptide with a dissociation constant (K D ) of at least 3 μM.
8. The recombinant antibody of claim 1 , wherein said antibody is a full length antibody.
9. The recombinant antibody of claim 1 , wherein said antibody is a monoclonal antibody.
10. The recombinant antibody of claim 1 , wherein said antibody is an antagonist antibody.
11. The recombinant antibody or antigen binding fragment of claim 1 , comprising a detectable label.
12. The recombinant antibody or antigen binding fragment of claim 11 , wherein the detectable label is a radioactive or fluorescent label.
13. A sterile composition comprising the recombinant antibody or antigen binding fragment of claim 1 .
14. The sterile composition of claim 13 , wherein said sterile composition comprises an aqueous carrier.
15. The sterile composition of claim 14 , wherein said aqueous carrier comprises one or more of water, saline, or buffer.
16. The recombinant antibody or antigen binding fragment of claim 1 , which binds to a polypeptide having the amino acid sequence of residues 1-168 of SEQ ID NO: 2.
17. A monoclonal antibody or antigen binding fragment thereof, that binds to a polypeptide having the amino acid sequence of SEQ ID NO:2.
18. The antigen binding fragment of claim 17 selected from:
a) a Fab fragment;
b) a Fab 2 fragment; or
c) a single chain antibody.
19. The monoclonal antibody of claim 17 , wherein said antibody is a full length antibody.
20. The monoclonal antibody of claim 17 , wherein said antibody is an antagonist antibody.
21. The monoclonal antibody or antigen binding fragment of claim 17 , comprising a detectable label.
22. The monoclonal antibody or antigen binding fragment of claim 21 , wherein the detectable label is a radioactive or fluorescent label.
23. The monoclonal antibody or antigen binding fragment of claim 17 , which binds said polypeptide with an affinity of at least 100 nM.
24. The monoclonal antibody or antigen binding fragment of claim 17 , which binds said polypeptide with an affinity of at least 30 nM.
25. The monoclonal antibody or antigen binding fragment of claim 17 , which binds said polypeptide with an affinity of at least 10 nM.
26. The monoclonal antibody or antigen binding fragment of claim 17 , which binds said polypeptide with an affinity of at least 3 nM.
27. The monoclonal antibody or antigen binding fragment of claim 17 , which binds said polypeptide with a dissociation constant (K D ) of at least 3 μM.
28. A sterile composition comprising the monoclonal antibody or antigen binding fragment of claim 17 .
29. The sterile composition of claim 28 , wherein said sterile composition comprises an aqueous carrier.
30. The sterile composition of claim 29 , wherein said aqueous carrier comprises one or more of water, saline, or buffer.
31. The monoclonal antibody or antigen binding fragment of claim 17 , which binds to a polypeptide having the amino acid sequence of residues 1-168 of SEQ ID NO: 2.