Glue compositions for lung volume reduction
View Patent ↗The present invention relates to methods and compositions for sealing localized regions of damaged lung tissue to reduce overall lung volume. The glue compositions provide a glue featuring an adhering moiety coupled to one or more other moieties including, for example, a cross-linkable moiety and/or one other adhering moiety. The methods and compositions of the invention find use, for example, in treating pulmonary conditions, such as emphysema.
1. A biocompatible tissue sealing composition comprising:
a cross-linking moiety of a heat stabilized glutaraldehyde;
a pharmaceutically acceptable carrier;
an albumin as a cross-likable moiety; and
an adhering moiety coupled to the cross-linkable moiety, the adhering moiety comprising a member selected from the group consisting of alpha-1-antitrypsin, elafin, and a serpin,
wherein the albumin is covalently linked to the cross-linking moiety, and
wherein the pharmaceutically acceptable carrier is sodium glutamate.
2. A biocompatible tissue sealing composition comprising:
a cross-linking moiety of a heat stabilized glutaraldehyde;
a pharmaceutically acceptable carrier;
an albumin as a cross-linkable moiety; and
an adhering moiety coupled to the cross-linkable moiety, the adhering moiety comprising a member selected from the group consisting of alpha-1-antitrvpsin, elafin, and a serpin,
wherein the albumin is covalently linked to the cross-linking moiety, and
wherein the pharmaceutically acceptable carrier is cysteine hydrochloride.
3. A biocompatible tissue sealing composition comprising:
a cross-linking moiety of a heat stabilized glutaraldehyde;
a pharmaceutically acceptable carrier;
an albumin as a cross-linkable moiety; and
an adhering moiety coupled to the cross-linkable moiety, the adhering moiety comprising a member selected from the group consisting of alpha-1-antitrvpsin, elafin, and a serpin,
wherein the albumin is covalently linked to the cross-linking moiety, and
wherein the pharmaceutically acceptable carrier is liposomes.
4. A biocompatible tissue sealing composition comprising:
a cross-linking moiety of a heat stabilized glutaraldehyde;
an albumin as a cross-linkable moiety;
an adhering moiety coupled to the cross-linkable moiety, the adhering moiety comprising a member selected from the group consisting of alpha-1-antitrvpsin, elafin, and a serpin; and
a pharmaceutically acceptable carrier comprising a member selected from the group consisting of sodium glutamate, cysteine hydrochloride, and a liposome,
wherein the albumin is covalently linked to the cross-linking moiety.
5. The biocompatible tissue sealing composition as recited in claim 4 , wherein said albumin is mammalian albumin.
6. The biocompatible tissue sealing composition as recited in claim 4 , wherein said albumin is porcine albumin.
7. The biocompatible tissue sealing composition as recited in claim 4 , wherein said albumin is human albumin.
8. The biocompatible tissue sealing composition as recited in claim 4 , wherein said albumin is bovine albumin.
9. The biocompatible tissue sealing composition as recited in claim 4 , wherein said albumin is recombinant albumin.