Glue composition for lung volume reduction
View Patent ↗The present invention relates to methods and compositions for sealing localized regions of damaged lung tissue to reduce overall lung volume. The glue compositions provide a glue featuring an adhering moiety coupled to one or more other moieties including, for example, a cross-linkable moiety and/or one other adhering moiety. The methods and compositions of the invention find use, for example, in treating pulmonary conditions, such as emphysema.
1. A glue composition comprising:
a first adhering moiety connected via an amide bond linkage to a first site on a coupling moiety which is a chemical linker; and
a second adhering moiety which is connected via an amide bond to a second site on said coupling moiety,
wherein said first and second adhering moieties adhere to different sites bearing elastase in a lung, and each adhering moiety is a member selected from the group consisting of alpha-1 antitrypsin, elafin, and a serpin, and wherein said chemical linker comprises two functional groups.
2. The glue composition according to claim 1 , wherein at least one of said functional groups of the chemical linker is a carboxyl group, an ester group, or an amine group, or wherein said chemical linker comprises a lysine.