Tissue volume reduction
View Patent ↗Devices, compositions, and methods for achieving non-surgical lung volume reduction (e.g., bronchoscopic lung volume reduction (BLVR)) are described. BLVR can be carried out by collapsing a region of the lung, adhering one portion of the collapsed region to another, and promoting fibrosis in or around the adherent tissue.
1. A method of preparing a diseased region of a lung for volume reduction, the method comprising introducing a material into a diseased region of a lung to reduce the volume of the diseased region, wherein the material is introduced via a bronchoscope, and wherein the material comprises an anti-surfactant or an adhesive, or another biocompatible reagent, or a combination of two or more thereof; and removing the material by suction.
2. The method of claim 1 , wherein the material comprises fibrinogen.
3. The method of claim 1 , wherein the material comprises 3-12% fibrinogen.
4. The method of claim 1 , wherein the material comprises approximately 10% fibrinogen.
5. The method of any one of the claims 1 , 2 , 3 , or 4 , wherein the material comprises an antibiotic.