Particulate cartilage system
View Patent ↗The present invention is directed to compositions having at least one neocartilage particle, juvenile cartilage particle or a combination thereof and a matrix, and methods and devices that include the compositions.
1. A composition comprising a cartilage-growth enhancing material comprising minced juvenile cartilage particles and a matrix.
2. The composition of claim 1 , wherein the matrix comprises a biocompatible chondro-inductive matrix.
3. The composition of claim 1 , wherein the matrix comprises a biocompatible chondro-conductive matrix.
4. The composition of claim 1 , wherein the juvenile cartilage particles comprise articular cartilage.
5. The composition of claim 1 , wherein juvenile cartilage particles include one dimension of about 1 mm.
6. The composition of claim 1 , wherein juvenile cartilage particles are 1 to 27 mm 3 .
7. The composition of claim 1 , wherein the juvenile cartilage particles are from a human donor less than fifteen years of age at the time of donation.
8. The composition of claim 1 , wherein the juvenile cartilage particles are from a human donor less than two years of age at the time of donation.
9. The composition of claim 1 , wherein the juvenile cartilage particles are from a human donor that is prepubescent at the time of donation.
10. The composition of claim 1 , wherein the juvenile cartilage particles are from a donor non-autologous to a recipient.
11. The composition of claim 1 , wherein the juvenile cartilage particles are distributed within about 60% or less of the matrix.
12. The composition of claim 1 wherein the juvenile cartilage particles are distributed within about 20% or less of the matrix.
13. The composition of claim 1 , further comprising a retainer.
14. The composition of claim 13 , wherein the retainer is selected from the group consisting of a flap, a plug, a disc, a sheet and a patch.
15. The composition of claim 13 , wherein the retainer comprises a periosteal flap.
16. The composition of claim 13 , wherein the retainer comprises a synthetic membrane.
17. The composition of claim 13 , wherein the retainer comprises a sutureless attachment.
18. The composition of claim 1 , wherein the matrix comprises fibrin.
19. The composition of claim 1 , wherein the matrix comprises polyethylene glycol.
20. The composition of claim 1 , wherein the matrix is selected from the group consisting of plasma-based adhesives or sealants, protein-based adhesives or sealants, natural adhesives or sealants, and any combination thereof.
21. The composition of claim 1 , wherein the matrix comprises an osteo-conductive matrix.
22. The composition of claim 1 , the matrix further comprising a storage solution.
23. A composition comprising a cartilage-growth enhancing material including minced juvenile cartilage particles, from a non-autologous source, and a matrix.
24. The composition of claim 23 , wherein the matrix comprises a biocompatible chondro-conductive a matrix.
25. The composition of claim 23 , wherein the matrix comprises a biocompatible chondro-inductive matrix.
26. The composition of claim 23 , wherein the matrix comprises a biocompatible chondro-conductive matrix.
27. The composition of claim 23 , wherein the juvenile cartilage particles comprise articular cartilage.
28. The composition of claim 23 , wherein juvenile cartilage particles include one dimension of about 1 mm.
29. The composition of claim 23 , wherein the juvenile cartilage particles are 1 to 27 mm 3 .
30. The composition of claim 23 , wherein the juvenile cartilage particles are from a human donor less than fifteen years of age at the time of donation.
31. The composition of claim 23 , wherein the juvenile cartilage particles are from a human donor less than two years of age at the time of donation.
32. The composition of claim 23 , wherein the juvenile cartilage particles are from a human donor that is prepubescent at the time of donation.
33. The composition of claim 23 , wherein the juvenile cartilage particles are from a donor non-autologous to a recipient.
34. The composition of claim 23 , wherein the juvenile cartilage particles are distributed within about 60% or less of the matrix.
35. The composition of claim 23 , wherein the juvenile cartilage particles are distributed within about 20% or less of the matrix.
36. The composition of claim 23 , further comprising a retainer.
37. The composition of claim 23 , wherein the retainer is selected from the group consisting of a flap, a plug, a disc, a sheet and a patch.
38. The composition of claim 23 , wherein the retainer comprises a periosteal flap.
39. The composition of claim 23 , wherein the retainer comprises a synthetic membrane.
40. The composition of claim 23 , wherein the retainer comprises a sutureless attachment.
41. The composition of claim 23 , wherein the matrix comprises fibrin.
42. The composition of claim 23 , wherein the matrix comprises polyethylene glycol.
43. The composition of claim 23 , wherein the matrix comprises an osteo-conductive matrix.
44. The composition of claim 23 , further comprising a storage solution.
45. A composition comprising a cartilage-growth enhancing material including minced neocartilage particles and a matrix.
46. The composition of claim 45 , wherein the matrix comprises a biocompatible chondro-inductive matrix.
47. The composition of claim 45 , wherein the matrix comprises a biocompatible chondro-conductive matrix.
48. The composition of claim 45 , wherein the neocartilage particles comprise articular cartilage.
49. The composition of claim 45 , wherein the neocartilage particles include one dimension of about 1 mm.
50. The composition of claim 45 , wherein neocartilage particles are 1 to 27 mm 3 .
51. The composition of claim 45 , wherein the neocartilage particles are from a human donor less than fifteen years of age at the time of donation.
52. The composition of claim 45 , wherein the neocartilage particles are from a human donor less than two years of age at the time of donation.
53. The composition of claim 45 , wherein the neocartilage particles are from a prepubescent human donor at the time of donation.
54. The composition of claim 45 , wherein the neocartilage particles are from a donor non-autologous to a recipient.
55. The composition of claim 45 , wherein the neocartilage particles are distributed within about 60% or less of the matrix.
56. The composition of claim 45 , wherein the neocartilage particles are distributed within about 20% or less of the matrix.
57. The composition of claim 45 , further comprising a retainer.
58. The composition of claim 57 , wherein the retainer is selected from the group consisting of a flap, a plug, a disc, a sheet and a patch.
59. The composition of claim 57 , wherein the retainer comprises a periosteal flap.
60. The composition of claim 57 , wherein the retainer comprises a synthetic membrane.
61. The composition of claim 57 , wherein the retainer comprises a sutureless attachment.
62. The composition of claim 45 , wherein the matrix comprises fibrin.
63. The composition of claim 45 , wherein the matrix comprises polyethylene glycol.
64. The composition of claim 45 , wherein the matrix is selected from the group consisting of plasma-based adhesives or sealants, and protein-based adhesives or sealants, natural adhesives or sealants and any combination thereof.
65. The composition of claim 45 , further comprising an osteo-conductive matrix.
66. The composition of claim 45 , further comprising a storage solution.
67. A composition comprising a cartilage-growth enhancing material including juvenile cartilage particles of 1 to 27 mm 3 and a matrix.
68. The composition of claim 67 , wherein the matrix comprises a biocompatible chondro-inductive matrix.
69. The composition of claim 67 , wherein the matrix comprises a biocompatible chondro-conductive matrix.
70. The composition of claim 67 , wherein the juvenile cartilage particles comprise articular cartilage.
71. The composition of claim 67 , wherein the juvenile cartilage particles include one dimension of about 1 mm.
72. The composition of claim 67 , wherein the juvenile cartilage particles are minced.
73. The composition of claim 67 , wherein the juvenile cartilage particles are from a human donor less than fifteen years of age at the time of donation.
74. The composition of claim 67 , wherein the juvenile cartilage particles are from a human donor less than two years of age at the time of donation.
75. The composition of claim 67 , wherein the juvenile cartilage particles are from a prepubescent human donor at the time of donation.
76. The composition of claim 67 , wherein the juvenile cartilage particles are from a donor non-autologous to a recipient.
77. The composition of claim 67 , wherein the juvenile cartilage particles are distributed within about 60% or less of the matrix.
78. The composition of claim 67 , wherein juvenile cartilage particles are distributed within about 20% or less of the matrix.
79. The composition of claim 67 , further comprising a retainer.
80. The composition of claim 79 , wherein the retainer is selected from the group consisting of a flap, a plug, a disc, a sheet and a patch.
81. The composition of claim 79 , wherein the retainer comprises a periosteal flap.
82. The composition of claim 81 , wherein the retainer comprises a synthetic membrane.
83. The composition of claim 81 , wherein the retainer comprises a sutureless attachment.
84. The composition of claim 67 , wherein the matrix comprises fibrin.
85. The composition of claim 67 , wherein the matrix comprises polyethylene glycol.
86. The composition of claim 67 , wherein the matrix is selected from the group consisting of plasma-based adhesives or sealants, and protein-based adhesives or sealants, natural adhesives or sealants and any combination thereof.
87. The composition of claim 67 , wherein the matrix comprises an osteo-conductive matrix.
88. The composition of claim 67 , further comprising a storage solution.