IP Library › Granted Patent US 7,786,133
Granted Patent B2
US 7,786,133 · App. 11/015,196 · Granted Aug 31, 2010

Chemically modified small molecules

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Quick Facts
Patent No.
US 7,786,133
App. No.
11/015,196
Granted
Aug 31, 2010
Kind
B2
Abstract

The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a monodisperse or bimodal water-soluble oligomer composition. A conjugate of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the small molecule drug not attached to the water-soluble oligomer.

Claims (4)

1. 6-CH 3 —(OCH 2 CH 2 ) 7 —O-Naloxol or a pharmaceutically acceptable salt thereof.

2. α-6-CH 3 —(OCH 2 CH 2 ) 7 —O-Naloxol or a pharmaceutically acceptable salt thereof.

3. β-6-CH 3 —(OCH 2 CH 2 ) 7 —O-Naloxol or a pharmaceutically acceptable salt thereof.

4. A pharmaceutical composition comprising the compound of any one of claims 1 - 3 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

Assignments (10)
RELEASE OF SECURITY INTEREST Recorded Jul 19, 2024
From: HCR REDHILL SPV, LLC
To: REDHILL BIOPHARMA INC.; REDHILL BIOPHARMA LTD.
Reel/Frame 068034/0458 →
SECURITY INTEREST Recorded Jul 10, 2024
From: HCR COLLATERAL MANAGEMENT, LLC, AS ADMINISTRATIVE AGENT
To: HCR REDHILL SPV, LLC, AS SUCCESSOR ADMINISTRATIVE AGENT
Reel/Frame 067953/0105 →
RELEASE OF SECURITY INTEREST Recorded Apr 17, 2020
From: TC LENDING, LLC, AS COLLATERAL AGENT
To: NEKTAR THERAPEUTICS
Reel/Frame 053180/0009 →
SECURITY INTEREST Recorded Feb 24, 2020
From: REDHILL BIOPHARMA INC.
To: HCR COLLATERAL MANAGEMENT, LLC, AS ADMINISTRATIVE AGENT
Reel/Frame 051909/0460 →
RELEASE OF SECURITY INTEREST RECORDED AT REEL 28571, FRAME 0141 Recorded Oct 14, 2015
From: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
To: NEKTAR THERAPEUTICS
Reel/Frame 036866/0700 →
GRANT OF SECURITY INTEREST IN UNITED STATES PATENTS Recorded Oct 6, 2015
From: NEKTAR THERAPEUTICS
To: TC LENDING, LLC, AS COLLATERAL AGENT
Reel/Frame 036796/0562 →
PARTIAL RELEASE OF PATENTS Recorded Mar 11, 2013
From: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
To: NEKTAR THERAPEUTICS
Reel/Frame 029964/0920 →
GRANT OF SECURITY INTEREST Recorded Jul 17, 2012
From: NEKTAR THERAPEUTICS
To: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 028571/0141 →
MERGER Recorded Aug 31, 2009
From: NEKTAR THERAPEUTICS AL, CORPORATION
To: NEKTAR THERAPEUTICS
Reel/Frame 023196/0394 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 5, 2006
From: BENTLEY, MICHAEL D.; VIEGAS, TACEY X.; GOODIN, RICHARD R.; ZHAO, XUAN; CHENG, LIN
To: NEKTAR THERAPEUTICS AL, CORPORATION
Reel/Frame 018607/0341 →