IP Library › Granted Patent US 7,034,176
Granted Patent B2
US 7,034,176 · App. 11/016,543 · Granted Apr 25, 2006

Aminopropylphosphinic acids

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Quick Facts
Patent No.
US 7,034,176
App. No.
11/016,543
Granted
Apr 25, 2006
Kind
B2
Abstract

Intermediates used in the preparation of compounds of formula I, or a stereoisomer thereof, or a pharmaceutically acceptable form of either selected from the group consisting of a salt, a solvate and a combination thereof, with the exception of i) the racemate of (3-amino-2-hydroxypropyl)phosphinic acid; and ii) (2R/S,3R)-(3-amino-2-hydroxybutyl)phosphinic acid.

Claims (22)

1. A compound selected from the group consisting of:

ethyl-3-[(diethoxymethyl)(ethoxy)phosphoryl]-2-fluoropropanoate,

ethyl-(3-amino-2-fluoro-3-oxopropyl)(diethoxymethyl)phosphinate,

ethyl-(2R)-(3-chloro-2-hydroxypropyl)(1,1-diethoxyethyl)phosphinate,

ethyl-(2S)-(3-amino-2-hydroxypropyl)(1,1-diethoxyethyl)phosphinate,

ethyl-(2S)-(3-chloro-2-hydroxypropyl) (1,1-diethoxyethyl)phosphinate,

ethyl-(2R)-(3-amino-2-hydroxypropyl) (1,1-diethoxyethyl)phosphinate,

ethyl-[3-[N-(tert-butoxycarbonyl)amino]-2-oxopropyl](1,1-diethoxyethyl)phosphinate,

(2R)-3-(dibenzylamino)-2-fluoro-1-propanol,

(2R)3-amino-2-fluoro-1-propanol,

tert-butyl-(2R)-2-fluoro-3-hydroxypropylcarbamate,

tert-butyl-(2R)-2fluoro-3-iodopropylcarbamate,

methyl-(2S)-3-(dibenzylamino)-2-fluoropropanoate,

(2S)-3-(dibenzylamino)-2-fluoro1-propanol,

(2S)-3-amino-2-fluoro-1-propanol,

tert-butyl-(2S)-2-fluoro-3-hydroxypropylcarbamat,

tert-butyl-(2S)-2-fluoro-3-iodopropylcarbamate,

ethyl-(fluoromethyl)(1,1-diethoxyethyl)phosphinate,

ethyl-(3-(N-(tert-butoxycarbonyl)amino)-1-fluoro-2-oxopropyl)(1,1-diethoxyethyl)phosphinate,

ethyl-(3-(N-(tert-butoxycarbonyl)amino)-1-fluoro-2-hydroxypropyl)(1,1-diethoxyethyl)phosphinate,

ethyl-3-[(diethoxymethyl)(ethoxy)phosphoryl]-2-fluorobutanoate, and

ethyl-3-amino-2-fluoro-1-methyl-3-oxopropyl (diethoxymethyl)phosphinate.